R
Ronald Feitosa Pinheiro
Researcher at Federal University of Ceará
Publications - 70
Citations - 628
Ronald Feitosa Pinheiro is an academic researcher from Federal University of Ceará. The author has contributed to research in topics: Medicine & Myelodysplastic syndromes. The author has an hindex of 10, co-authored 58 publications receiving 327 citations.
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Journal ArticleDOI
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Journal ArticleDOI
Polymorphisms of DNA repair genes are related to the pathogenesis of myelodysplastic syndrome.
Howard Lopes Ribeiro,Roberta Taiane Germano de Oliveira,Allan Rodrigo Soares Maia,Luiz Ivando Pires Ferreira Filho,Juliana Cordeiro de Sousa,Fabiola Fernandes Heredia,Silvia Maria Meira Magalhães,Ronald Feitosa Pinheiro +7 more
TL;DR: The results support the importance of RAD51, XRCC5 andXRCC6 genes polymorphisms in the maintenance of genomic stability promoting a better understanding of the genesis and etiology of Myelodysplastic Syndrome.
Journal ArticleDOI
TLR4 deficiency upregulates TLR9 expression and enhances irinotecan-related intestinal mucositis and late-onset diarrhoea.
Deysi Viviana Tenazoa Wong,Deysi Viviana Tenazoa Wong,Renata Brito Falcão Holanda,Aurilene Gomes Cajado,Alessandro Maia Bandeira,Jorge Fernando Bessa Pereira,Joice Oliveira Amorim,Clarice Sampaio Torres,Luana Maria Moura Ferreira,Marina Helena Silva Lopes,Roberta Taiane Germano de Oliveira,Anamaria Falcão Pereira,Rosane Oliveira Sant'Ana,Larissa Mont'alverne Arruda,Howard Lopes Ribeiro-Júnior,Ronald Feitosa Pinheiro,Paulo Roberto Carvalho Almeida,Robson Francisco Carvalho,Fábio Figueiredo Chaves,Duílio R. Rocha-Filho,Fernando Q. Cunha,Roberto C. P. Lima-Júnior +21 more
TL;DR: In this article, colorectal cancer patients carrying missense TLR4 A896G or C1,196T (rs4986790) or Tlr4 knockout (Tlr4-/-) mice were given irinotecan to investigate the severity of the induced diarrhoea.
Journal ArticleDOI
HFE gene mutation and oxidative damage biomarkers in patients with myelodysplastic syndromes and its relation to transfusional iron overload: an observational cross-sectional study.
Geane Felix de Souza,Howard Lopes Ribeiro,Juliana Cordeiro de Sousa,Fabiola Fernandes Heredia,Rivelilson Mendes de Freitas,Manoel Ricardo Alves Martins,Romélia Pinheiro Gonçalves,Ronald Feitosa Pinheiro,Silvia Maria Meira Magalhães +8 more
TL;DR: Results show that excess iron intensifies the process of cell damage through oxidative stress, suggesting an increased lipid peroxidation in patients with myelodysplastic syndromes and IOL.
Journal ArticleDOI
TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
Elsa Bernard,Yasuhito Nannya,Tetsuichi Yoshizato,Robert P. Hasserjian,Ryunosuke Saiki,Yusuke Shiozawa,Sean M. Devlin,Heinz Tuechler,Araxe Sarian,Luca Malcovati,Francesc Solé,Detlef Haase,Maria Creignou,Max Levine,Ulrich Germing,Catherine Cargo,Yanming Zhang,Juan Medina,Juan E. Arango Ossa,Julie Schanz,Arjan A. van de Loosdrecht,Martin Jädersten,John M. Bennett,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio Ps Santos,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee-Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellstrom Lindberg,Seishi Ogawa,Elli Papaemmanuil +74 more
TL;DR: The established association between mutated TP53 and complex karyotype is specific to the multi-hit TP53 state and is found to be an independent prognostic factor for overall survival and AML transformation.