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Yasuhito Nannya
Researcher at Kyoto University
Publications - 290
Citations - 6802
Yasuhito Nannya is an academic researcher from Kyoto University. The author has contributed to research in topics: Medicine & Transplantation. The author has an hindex of 36, co-authored 231 publications receiving 5428 citations. Previous affiliations of Yasuhito Nannya include University of Tokyo & Gifu University.
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Journal ArticleDOI
A Robust Algorithm for Copy Number Detection Using High-Density Oligonucleotide Single Nucleotide Polymorphism Genotyping Arrays
Yasuhito Nannya,Masashi Sanada,Kumi Nakazaki,Noriko Hosoya,Lili Wang,Akira Hangaishi,Mineo Kurokawa,Shigeru Chiba,Dione K. Bailey,Giulia C. Kennedy,Seishi Ogawa +10 more
TL;DR: Improvements in signal-to-noise ratios and the use of an optimized reference make CNAG a useful tool for high-resolution detection of copy number alterations which can help in the understanding of the pathogenesis of cancers and other diseases as well as in exploring the complexities of the human genome.
Journal ArticleDOI
Age-related remodelling of oesophageal epithelia by mutated cancer drivers
Akira Yokoyama,Nobuyuki Kakiuchi,Tetsuichi Yoshizato,Yasuhito Nannya,Hiromichi Suzuki,Yasuhide Takeuchi,Yusuke Shiozawa,Yusuke Sato,Kosuke Aoki,Soo Ki Kim,Yoichi Fujii,Kenichi Yoshida,Keisuke Kataoka,Masahiro Nakagawa,Yoshikage Inoue,Tomonori Hirano,Yuichi Shiraishi,Kenichi Chiba,Hiroko Tanaka,Masashi Sanada,Yoshitaka Nishikawa,Yusuke Amanuma,Shinya Ohashi,Ikuo Aoyama,Takahiro Horimatsu,Shin'ichi Miyamoto,Shigeru Tsunoda,Yoshiharu Sakai,Maiko Narahara,J.B. Brown,Yoshitaka Sato,Genta Sawada,Koshi Mimori,Sachiko Minamiguchi,Hironori Haga,Hiroshi Seno,Satoru Miyano,Hideki Makishima,Manabu Muto,Seishi Ogawa,Seishi Ogawa +40 more
TL;DR: In physiologically normal epithelia, age-related expansion of clones that carry mutations in NOTCH1 and other driver genes is accelerated by risk factors for developing oesophageal squamous cell carcinoma, such as alcohol consumption or smoking.
Journal ArticleDOI
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Journal ArticleDOI
Prospective Comparison of the Diagnostic Potential of Real-Time PCR, Double-Sandwich Enzyme-Linked Immunosorbent Assay for Galactomannan, and a (1→3)-β-d-Glucan Test in Weekly Screening for Invasive Aspergillosis in Patients with Hematological Disorders
Masahito Kawazu,Yoshinobu Kanda,Yasuhito Nannya,Katsunori Aoki,Mineo Kurokawa,Shigeru Chiba,Toru Motokura,Hisamaru Hirai,Seishi Ogawa +8 more
TL;DR: The double-sandwich ELISA test was the most sensitive at predicting the diagnosis of IA in high-risk patients with hematological disorders, using a reduced cutoff of 0.6 O.D.I.
Journal ArticleDOI
Highly Sensitive Method for Genomewide Detection of Allelic Composition in Nonpaired, Primary Tumor Specimens by Use of Affymetrix Single-Nucleotide–Polymorphism Genotyping Microarrays
Go Yamamoto,Yasuhito Nannya,Motohiro Kato,Masashi Sanada,Ross L. Levine,Norihiko Kawamata,Akira Hangaishi,Mineo Kurokawa,Shigeru Chiba,D. Gary Gilliland,H. Phillip Koeffler,Seishi Ogawa +11 more
TL;DR: A simple but highly sensitive method for genomewide detection of allelic composition, based on the Affymetrix single-nucleotide-polymorphism genotyping microarray platform, without dependence on the availability of constitutive DNA, is described and should substantially improve the ability to dissect the complexity of cancer genomes.