M
Maria Creignou
Researcher at Karolinska University Hospital
Publications - 22
Citations - 366
Maria Creignou is an academic researcher from Karolinska University Hospital. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 8 publications receiving 122 citations. Previous affiliations of Maria Creignou include Karolinska Institutet.
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Journal ArticleDOI
Implications of TP53 allelic state for genome stability, clinical presentation and outcomes in myelodysplastic syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: Clinical sequencing across a large prospective cohort of patients with myelodysplasic syndrome uncovers distinct associations between the mono- and biallelic states of TP53 and clinical presentation.
Journal ArticleDOI
TP53 State Dictates Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
Elsa Bernard,Yasuhito Nannya,Tetsuichi Yoshizato,Robert P. Hasserjian,Ryunosuke Saiki,Yusuke Shiozawa,Sean M. Devlin,Heinz Tuechler,Araxe Sarian,Luca Malcovati,Francesc Solé,Detlef Haase,Maria Creignou,Max Levine,Ulrich Germing,Catherine Cargo,Yanming Zhang,Juan Medina,Juan E. Arango Ossa,Julie Schanz,Arjan A. van de Loosdrecht,Martin Jädersten,John M. Bennett,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio Ps Santos,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee-Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellstrom Lindberg,Seishi Ogawa,Elli Papaemmanuil +74 more
TL;DR: The established association between mutated TP53 and complex karyotype is specific to the multi-hit TP53 state and is found to be an independent prognostic factor for overall survival and AML transformation.
Journal ArticleDOI
ZBTB33 is mutated in clonal hematopoiesis and myelodysplastic syndromes and impacts RNA splicing.
Ellen M. Beauchamp,Ellen M. Beauchamp,Matthew Leventhal,Matthew Leventhal,Elsa Bernard,Emma R. Hoppe,Emma R. Hoppe,Gabriele Todisco,Gabriele Todisco,Maria Creignou,Anna Gallì,Cecilia A. Castellano,Cecilia A. Castellano,Marie McConkey,Marie McConkey,Akansha Tarun,Akansha Tarun,Waihay J. Wong,Waihay J. Wong,Monica Schenone,Caroline Stanclift,Benjamin Tanenbaum,Edyta Malolepsza,Björn Nilsson,Björn Nilsson,Björn Nilsson,Alexander G. Bick,Alexander G. Bick,Joshua S. Weinstock,Mendy Miller,Abhishek Niroula,Abhishek Niroula,Andrew Dunford,Amaro Taylor-Weiner,Timothy Wood,Alex Barbera,Shankara Anand,Bruce M. Psaty,Bruce M. Psaty,Pinkal Desai,Michael H. Cho,Andrew D. Johnson,Ruth J. F. Loos,Daniel G. MacArthur,Monkol Lek,Monkol Lek,Monkol Lek,Donna Neuberg,Kasper Lage,Kasper Lage,Steven A. Carr,Eva Hellström-Lindberg,Luca Malcovati,Elli Papaemmanuil,Chip Stewart,Gad Getz,Gad Getz,Robert K. Bradley,Robert K. Bradley,Siddhartha Jaiswal,Benjamin L. Ebert,Benjamin L. Ebert,Benjamin L. Ebert +62 more
TL;DR: Common mutations in the 5-methylcytosine reader, ZBTB33, as well as in YLPM1, SRCAP, and ZNF318 are identified, potentially linking DNA methylation and RNA splicing, the two most commonly mutated pathways in clonal hematopoiesis and MDS.
Posted ContentDOI
Implications of TP53 Allelic State for Genome Stability, Clinical Presentation and Outcomes in Myelodysplastic Syndromes
Elsa Bernard,Yasuhito Nannya,Robert P. Hasserjian,Sean M. Devlin,Heinz Tuechler,Juan S. Medina-Martinez,Tetsuichi Yoshizato,Yusuke Shiozawa,Ryunosuke Saiki,Luca Malcovati,Max Levine,Juan E. Arango,Yangyu Zhou,Francesc Solé,Catherine Cargo,Detlef Haase,Maria Creignou,Ulrich Germing,Yanming Zhang,Gunes Gundem,Araxe Sarian,Arjan A. van de Loosdrecht,Martin Jädersten,Magnus Tobiasson,Olivier Kosmider,Matilde Y. Follo,Felicitas Thol,Ronald Feitosa Pinheiro,Valeria Santini,Ioannis Kotsianidis,Jacqueline Boultwood,Fabio P.S. Santos,Julie Schanz,Senji Kasahara,Takayuki Ishikawa,Hisashi Tsurumi,Akifumi Takaori-Kondo,Toru Kiguchi,Chantana Polprasert,John M. Bennett,Virginia M. Klimek,Michael R. Savona,Monika Belickova,Christina Ganster,Laura Palomo,Guillermo Sanz,Lionel Ades,Matteo G. Della Porta,Alexandra Smith,Yesenia Werner,Minal Patel,Agnes Viale,Katelynd Vanness,Donna Neuberg,Kristen E. Stevenson,Kamal Menghrajani,Kelly L. Bolton,Pierre Fenaux,Andrea Pellagatti,Uwe Platzbecker,Michael Heuser,Peter Valent,Shigeru Chiba,Yasushi Miyazaki,Carlo Finelli,Maria Teresa Voso,Lee Yung Shih,Michaela Fontenay,Joop H. Jansen,José Cervera,Yoshiko Atsuta,Norbert Gattermann,Benjamin L. Ebert,Rafael Bejar,Peter L. Greenberg,Mario Cazzola,Eva Hellström-Lindberg,Seishi Ogawa,Elli Papaemmanuil +78 more
TL;DR: TP53 multi-hit state predicted risk of death and leukemic transformation independently of the Revised International Prognostic Scoring System, while mono-allelic patients did not differ from TP53 wild-type patients and the separation by allelic state was retained in therapy-related MDS.
Journal ArticleDOI
Co-mutation pattern, clonal hierarchy, and clone size concur to determine disease phenotype of SRSF2P95-mutated neoplasms.
Gabriele Todisco,Gabriele Todisco,Maria Creignou,Maria Creignou,Anna Gallì,Paola Guglielmelli,Elisa Rumi,Marco Roncador,Ettore Rizzo,Yasuhito Nannya,Daniela Pietra,Chiara Elena,Elisa Bono,Elisabetta Molteni,Vittorio Rosti,Silvia Catricalà,Martina Sarchi,Marios Dimitriou,Johanna Ungerstedt,Johanna Ungerstedt,Alessandro M. Vannucchi,Eva Hellström-Lindberg,Eva Hellström-Lindberg,Seishi Ogawa,Seishi Ogawa,Mario Cazzola,Luca Malcovati +26 more
TL;DR: Evidence is provided that co-mutation pattern, clone size, and hierarchy concur to determine clinical phenotype, tracing relevant genotype–phenotype associations across disease entities and giving insight on unaccountable clinical heterogeneity within current WHO classification categories.