C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Infantile bilateral striatal necrosis maps to chromosome 19q
Lina Basel-Vanagaite,Rachel Straussberg,H. Ovadia,A. Kaplan,Nurit Magal,Zamir Shorer,Hadar Shalev,Christopher A. Walsh,Mordechai Shohat +8 more
TL;DR: The presence of a common haplotype in all the patients suggests that the disease is caused by a single mutation derived from a single ancestral founder in all of the families.
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Somatic mutations in single human cardiomyocytes reveal age-associated DNA damage and widespread oxidative genotoxicity
Sangita Choudhury,August Yue Huang,Junho Kim,Zinan Zhou,Katherine S Morillo,Eduardo A Maury,Jessica W. Tsai,Michael B. Miller,Michael A. Lodato,Sarah Araten,Nazia Hilal,Eunjung Lee,Ming-Hui Chen,Christopher A. Walsh +13 more
TL;DR: In this paper , the authors used single-cell whole-genome sequencing to identify and characterize the landscape of somatic single-nucleotide variants (sSNVs) in 56 single cardiomyocytes from 12 individuals (aged from 0.4 to 82 years).
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What Are Mini-Brains?
TL;DR: The method to grow miniature human brain-like structures (cerebral organoids) from embryonic stem cells in vitro recapitulate a surprising number of features of human embryonic brain development, heralding a new phase of modeling human disease.
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Numb, neurogenesis and epithelial polarity.
Seonhee Kim,Christopher A. Walsh +1 more
TL;DR: A crucial role for Numb is shown in the maintenance of radial glia adherens junctions and, consequently, the integrity of the neurogenic epithelium.