C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
X-linked malformations of neuronal migration
William B. Dobyns,Eva Andermann,F. Andermann,Desiree Czapansky-Beilman,François Dubeau,Olivier Dulac,Renzo Guerrini,Betsy A. Hirsch,David H. Ledbetter,Namsoo Lee,Jacques Motte,J. M. Pinard,Rodney A. Radtke,M. E. Ross,Donatella Tampieri,Christopher A. Walsh,Chip Truwit +16 more
TL;DR: Evidence supporting the existence of two distinct X-linked malformations of neuronal migration is reviewed and Bilateral periventricular nodular heterotopia (BPNH) usually presents with sporadic or familial epilepsy with normal intelligence, primarily in females, although the authors have evaluated two boys with BPNH and severe mental retardation.
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Cdk5rap2 regulates centrosome function and chromosome segregation in neuronal progenitors
Sofia B. Lizarraga,Steven P. Margossian,Steven P. Margossian,Marian H. Harris,Marian H. Harris,Dean R. Campagna,An-Ping Han,Sherika Blevins,Raksha Mudbhary,Jane E. Barker,Christopher A. Walsh,Mark D. Fleming +11 more
TL;DR: The findings suggest that the reduction in brain size observed in humans with mutations in CDK5RAP2 is associated with impaired centrosomal function and with changes in mitotic spindle orientation during progenitor proliferation.
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Clonal dispersion in proliferative layers of developing cerebral cortex
TL;DR: Progenitor cell dispersion represents a previously unrecognized mode of migration by which sibling cells become widely dispersed in the developing forebrain.
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Cell-Type-Specific Alternative Splicing Governs Cell Fate in the Developing Cerebral Cortex.
Xiaochang Zhang,Xiaochang Zhang,Ming-Hui Chen,Xuebing Wu,Andrew Kodani,Jean Fan,Ryan N. Doan,Ryan N. Doan,Manabu Ozawa,Jacqueline Ma,Nobuaki Yoshida,Jeremy F. Reiter,Douglas L. Black,Peter V. Kharchenko,Phillip A. Sharp,Christopher A. Walsh +15 more
TL;DR: It is shown that dynamic control of alternative splicing governs cell fate in cerebral cortical development by regulating neuron-specific exons in NPCs and Rbfox proteins.
Journal ArticleDOI
Human brain malformations and their lessons for neuronal migration
M. E. Ross,Christopher A. Walsh +1 more
TL;DR: Genetic studies of human brain malformation have proven a surprising source for finding the molecules that regulate CNS neuronal migration, and this work notes both what is now known of their genetic bases and what remains to be discovered.