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Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
An autosomal recessive form of spastic cerebral palsy (CP) with microcephaly and mental retardation.
Anna Rajab,Seung-Yun Yoo,Seung-Yun Yoo,Aiman Abdulgalil,Salem Kathiri,Riaz Ahmed,Ganeshwaran H. Mochida,Ganeshwaran H. Mochida,Ganeshwaran H. Mochida,Adria Bodell,Adria Bodell,A. James Barkovich,Christopher A. Walsh,Christopher A. Walsh +13 more
TL;DR: A large consanguineous family from Oman with spastic diplegia, microcephaly, and mental retardation is identified, and additional manifestations include hyperreflexia, clumsiness, unstable gait, drooling, and dysarthria.
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Genomic structural variants are linked with intellectual disability
Kazima B. Bulayeva,Klaus-Peter Lesch,Oleg Bulayev,Christopher A. Walsh,Christopher A. Walsh,Stephen J. Glatt,Stephen J. Glatt,Farida Gurgenova,Jamilja Omarova,Irina N. Berdichevets,Paul M. Thompson +10 more
TL;DR: The authors' linkage and structural genomic variation analyses in a remote highland genetic isolate with aggregation of ID demonstrated that even highly isolated single kindred ID has oligo/polygenic pathogenesis.
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Clonal mixing, clonal restriction, and specification of cell types in the developing rat olfactory bulb.
TL;DR: In this paper, a hierarchical cell lineage is proposed that involves a multipotential progenitor that gives rise to potentially more limited progenitors, likely at a stage before formation of the olfactory rostral migratory stream.
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FLNA genomic rearrangements cause periventricular nodular heterotopia
K.R. Clapham,Timothy W. Yu,Vijay S. Ganesh,Brenda J. Barry,Y. Chan,Davide Mei,Elena Parrini,B. Funalot,L. Dupuis,M.M. Nezarati,C. du Souich,C. van Karnebeek,Renzo Guerrini,Christopher A. Walsh +13 more
TL;DR: It is demonstrated that FLNA is prone to pathogenic rearrangements, and the importance of screening for CNVs in individuals with PNH lacking FLNA point mutations is highlighted.
Journal ArticleDOI
Brain Somatic Mutation in Aging and Alzheimer's Disease.
TL;DR: Somatic mutations arise postzygotically, producing genetic differences between cells in an organism as mentioned in this paper, and also exist in non-neoplastic cells, such as cancer cells.