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Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
Single-Cell, Genome-wide Sequencing Identifies Clonal Somatic Copy-Number Variation in the Human Brain
Xuyu Cai,Gilad D. Evrony,Hillel S. Lehmann,Hillel S. Lehmann,Hillel S. Lehmann,Princess C. Elhosary,Princess C. Elhosary,Princess C. Elhosary,Bhaven K. Mehta,Bhaven K. Mehta,Bhaven K. Mehta,Annapurna Poduri,Christopher A. Walsh +12 more
TL;DR: Analysis of a patient with hemimegalencephaly due to a somatic CNV of chromosome 1q found unexpected tetrasomy 1q in ~20% of neurons, suggesting that CNVs in a minority of cells can cause widespread brain dysfunction.
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Single-cell analysis reveals transcriptional heterogeneity of neural progenitors in human cortex
Matthew B. Johnson,Peter P. Wang,Kutay Deniz Atabay,Elisabeth A Murphy,Ryan N. Doan,Jonathan L. Hecht,Christopher A. Walsh +6 more
TL;DR: Single-cell transcriptional profiling in human, ferret and mouse revealed more cells coexpressing proneural neurogenin targets in human than in other species, suggesting greater neuronal lineage commitment and differentiation of self-renewing progenitors.
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Mutations in Human Accelerated Regions Disrupt Cognition and Social Behavior
Ryan N. Doan,Byoung-Il Bae,Beatriz Cubelos,Cindy Chang,Amer A. Hossain,Samira Al-Saad,Nahit Motavalli Mukaddes,Ozgur Oner,Muna Al-Saffar,Muna Al-Saffar,Soher Balkhy,Generoso G. Gascon,Marta Nieto,Christopher A. Walsh,Christopher A. Walsh,Christopher A. Walsh +15 more
TL;DR: Using chromatin interaction sequencing, massively parallel reporter assays, and transgenic mice, genetic evidence is provided that specific HARs are essential for normal development, consistent with suggestions that their evolutionary changes may have altered social and/or cognitive behavior.
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Cux1 and Cux2 regulate dendritic branching, spine morphology and synapses of the upper layer neurons of the cortex
Beatriz Cubelos,Álvaro Sebastián-Serrano,Leonardo Beccari,Maria Elisa Calcagnotto,Elsa Cisneros,Seonhee Kim,Ana Dopazo,Manuel Álvarez-Dolado,Juan Miguel Redondo,Paola Bovolenta,Christopher A. Walsh,Marta Nieto +11 more
TL;DR: Using knockout and knockdown studies combined with morphological, molecular, and electrophysiological analysis, it is shown that the homeobox Cux1 and Cux2 are intrinsic and complementary regulators of dendrite branching, spine development, and synapse formation in layer II-III neurons of the cortex.
Journal ArticleDOI
Systematic widespread clonal organization in cerebral cortex
TL;DR: The data suggest that migratory multipotential progenitors divide asymmetrically at intervals defined by cell cycle length, producing single cells or clusters of cells in different cortical regions, which may correspond to changes in migratory behavior.