C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number
Wen Fan Hu,Oz Pomp,Tawfeg Ben-Omran,Andrew Kodani,Katrin Henke,Katrin Henke,Ganeshwaran H. Mochida,Timothy W. Yu,Timothy W. Yu,Mollie B. Woodworth,Carine Bonnard,Grace Selva Raj,Thong Teck Tan,Hanan Hamamy,Amira Masri,Mohammad Shboul,Muna Al Saffar,Muna Al Saffar,Jennifer N. Partlow,Jennifer N. Partlow,Mohammed S. Al-Dosari,Anas M. Alazami,Mohammed Al-Owain,Fowzan S. Alkuraya,Jeremy F. Reiter,Matthew P. Harris,Matthew P. Harris,Bruno Reversade,Bruno Reversade,Christopher A. Walsh +29 more
TL;DR: Surprisingly, Katnb1 null mutant mouse embryos display hallmarks of aberrant Sonic hedgehog signaling, including holoprosencephaly, and KATNB1 null fibroblasts also demonstrate a remarkable excess of centrioles, with supernumerary cilia but deficient Hedgehog signaling.
Journal ArticleDOI
A homozygous mutation in the tight-junction protein JAM3 causes hemorrhagic destruction of the brain, subependymal calcification, and congenital cataracts.
Ganeshwaran H. Mochida,Ganeshwaran H. Mochida,Vijay S. Ganesh,Jillian M. Felie,Danielle Gleason,R. Sean Hill,R. Sean Hill,Katie Rose Clapham,Daniel P. Rakiec,Wen-Hann Tan,Nadia Akawi,Muna Al-Saffar,Jennifer N. Partlow,Sigrid Tinschert,A. James Barkovich,Bassam R. Ali,Lihadh Al-Gazali,Christopher A. Walsh,Christopher A. Walsh,Christopher A. Walsh +19 more
TL;DR: The results suggest that JAM3 is essential for maintaining the integrity of the cerebrovascular endothelium as well as for normal lens development in humans.
Journal ArticleDOI
CHMP1A encodes an essential regulator of BMI1-INK4A in cerebellar development
Ganeshwaran H. Mochida,Vijay S. Ganesh,María Isabel Quiroga de Michelena,Hugo Dias,Kutay Deniz Atabay,Katie L. Kathrein,Hsuan Ting Huang,R. Sean Hill,Jillian M. Felie,Daniel P. Rakiec,Danielle Gleason,Anthony D. Hill,Athar N. Malik,Brenda J. Barry,Jennifer N. Partlow,Wen-Hann Tan,Laurie Glader,A. James Barkovich,William B. Dobyns,Leonard I. Zon,Christopher A. Walsh +20 more
TL;DR: In this paper, the authors show that loss of function mutations in human CHMP1A cause reduced cerebellar size (pontocerebellar hypoplasia) and reduced cerebral cortical size (microcephaly).
Journal ArticleDOI
Bilateral periventricular nodular heterotopia due to filamin 1 gene mutation: widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex.
Akiyoshi Kakita,Shintaro Hayashi,Francesca Moro,Renzo Guerrini,Tsunenori Ozawa,Koji Ono,Shigeki Kameyama,Christopher A. Walsh,Hitoshi Takahashi +8 more
TL;DR: The histopathological features of an autopsy case of BPNH with widespread glomeruloid microvascular anomaly and dysplastic cytoarchitecture in the cerebral cortex, in whom a novel exon 11 (Val528Met) filamin 1 mutation is found.
Journal ArticleDOI
Lis1–Nde1-dependent neuronal fate control determines cerebral cortical size and lamination
Ashley S. Pawlisz,Christopher A. Mutch,Anthony Wynshaw-Boris,Anjen Chenn,Christopher A. Walsh,Christopher A. Walsh,Yuanyi Feng +6 more
TL;DR: The data suggest that maintaining the shape and cell–cell interactions of radial glial neuroepithelial progenitors by the Lis1–Nde1 complex is essential for their self renewal during the early phase of corticogenesis.