C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
Papers
More filters
Journal ArticleDOI
Loss of non-motor kinesin KIF26A causes congenital brain malformations via dysregulated neuronal migration and axonal growth as well as apoptosis.
Xuyu Qian,Ellen M DeGennaro,Maya Talukdar,Shyam K. Akula,Abbe Lai,Diane D. Shao,Dilenny M. Gonzalez,Jack H Marciano,Richard S. Smith,Norma K. Hylton,Edward Yang,J. Fernando Bazan,Lee Barrett,Rebecca C. Yeh,R. Sean Hill,Samantha G. Beck,Aoi Otani,Jolly Angad,Tadahiro Mitani,Jennifer E. Posey,Davut Pehlivan,Daniel G. Calame,Hatip Aydin,Osman Yeşilbaş,Kendall C. Parks,Emanuela Argilli,Eleina M. England,Kiho Im,Ajay Taranath,Hamish S. Scott,Christopher B. Barrett,Peer Arts,Elliott H. Sherr,James R. Lupski,Christopher A. Walsh +34 more
TL;DR: In this paper , the authors report a patient cohort with biallelic loss-of-function variants in KIF26A, exhibiting a spectrum of congenital brain malformations.
Journal ArticleDOI
Variants in ADD1 cause intellectual disability, corpus callosum dysgenesis, and ventriculomegaly in humans
Cai Qi,Jeremy Knox,Irena Feng,Ana Costa,Rita Pinto-Costa,Jennifer E. Neil,Oana Caluseriu,Dong Li,Rebecca D. Ganetzky,Charlotte Brasch-Andersen,Christina Fagerberg,Lars Kjærsgaard Hansen,Caleb Bupp,Colleen Muraresku,Xiangbin Ruan,Bowei Kang,Kaining Hu,Rong Zhong,Pedro Brites,Elizabeth J. Bhoj,Robert Sean Hill,Marni J. Falk,Hakon Hakonarson,Kristopher T. Kahle,Mónica Mendes Sousa,Christopher A. Walsh,Xiaochang Zhang +26 more
Book ChapterDOI
The Genetic Basis of Human Cerebral Cortical Malformations
TL;DR: This chapter highlights some of these malformations, including disorders of microcephaly, gray matter hetero-topia, lissencephaly syndromes, and polymicrogyria.
Posted ContentDOI
Identifying cell type specific driver genes in autism-associated copy number loci from cerebral organoids
Elaine T. Lim,Elaine T. Lim,Elaine T. Lim,Yingleong Chan,Yingleong Chan,Yingleong Chan,Mannix J. Burns,Mannix J. Burns,Mannix J. Burns,Xiaoge Guo,Xiaoge Guo,Serkan Erdin,Serkan Erdin,Derek J. C. Tai,Derek J. C. Tai,Julia M. Reichert,Julia M. Reichert,Julia M. Reichert,Ying Kai Chan,Ying Kai Chan,Jessica J. Chiang,Jessica J. Chiang,Katharina Meyers,Xiaochang Zhang,Christopher A. Walsh,Christopher A. Walsh,Bruce A. Yankner,Soumya Raychaudhuri,Soumya Raychaudhuri,Joel N. Hirschhorn,James F. Gusella,Michael E. Talkowski,Michael E. Talkowski,George M. Church,George M. Church +34 more
TL;DR: This work performs RNA sequencing on 71 samples comprising of 1,420 cerebral organoids from 25 donors, and describes a framework (Orgo-Seq) to identify cell type specific driver genes, for 16p11.2 deletions and 15q11-13 duplications, and discovers novel and previously reported cell typespecific driver genes.
Posted ContentDOI
Evidence that APP gene copy number changes reflect recombinant vector contamination [preprint]
Junho Kim,Boxun Zhao,August Yue Huang,Michael B. Miller,Michael B. Miller,Michael B. Miller,Michael A. Lodato,Christopher A. Walsh,Christopher A. Walsh,Eunjung Lee +9 more
TL;DR: Park et al. as discussed by the authors reanalyzed the data from the Lee study, revealing evidence that APP gencDNA originates mainly from contamination by exogenous APP recombinant vectors, rather from true somatic retrotransposition of endogenous APP.