C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
Genomic and Evolutionary Analyses of Asymmetrically Expressed Genes in Human Fetal Left and Right Cerebral Cortex
TL;DR: By comparing genes differentially expressed in left and right fetal brains with those previously reported to be differently expressed in human versus chimpanzee adult brains, a subset of genes that shows evidence of asymmetric expression in humans and altered expression levels between chimps and humans are identified.
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Biallelic mutations in human DCC cause developmental split-brain syndrome
Saumya Shekhar Jamuar,Saumya Shekhar Jamuar,Klaus Schmitz-Abe,Alissa M. D'Gama,Marie Drottar,Wai-Man Chan,Maya Peeva,Sarah Servattalab,Anh Thu N. Lam,Mauricio R. Delgado,Mauricio R. Delgado,Nancy J. Clegg,Zayed Al Zayed,Mohammad Asif Dogar,Ibrahim A. Alorainy,Abdullah Abu Jamea,Khaled K. Abu-Amero,May L. Griebel,Wendy L. Ward,Ed S. Lein,Kyriacos Markianos,A. James Barkovich,Caroline D. Robson,P. Ellen Grant,Thomas M. Bosley,Elizabeth C. Engle,Christopher A. Walsh,Timothy W. Yu,Timothy W. Yu,Timothy W. Yu +29 more
TL;DR: Findings show that DCC is a master regulator of midline crossing and development of white-matter projections throughout the human central nervous system (CNS), including loss of all commissural tracts at multiple levels of the neuraxis.
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Congenital Microcephaly with a Simplified Gyral Pattern: Associated Findings and Their Significance
Y. Adachi,Annapurna Poduri,A. Kawaguch,G. Yoon,M. A. Mohamed Salih,F. Yamashita,Christopher A. Walsh,A. J. Barkovich +7 more
TL;DR: A strong correlation was found between the degree of microcephaly, the volume of white matter, and the presence of a simplified gyral pattern, which should be considered when attempting to use neuroimaging for segregation and classification of patients with microCEphaly.
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CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis
M. Chiara Manzini,M. Chiara Manzini,M. Chiara Manzini,Lan Xiong,Ranad Shaheen,Dimira E. Tambunan,Dimira E. Tambunan,Dimira E. Tambunan,Stefania Di Costanzo,Stefania Di Costanzo,Stefania Di Costanzo,Vanessa Mitisalis,Vanessa Mitisalis,Vanessa Mitisalis,David J. Tischfield,David J. Tischfield,David J. Tischfield,Antonella Cinquino,Antonella Cinquino,Antonella Cinquino,Mohammed Ghaziuddin,Mehtab Christian,Qin Jiang,Sandra Laurent,Zohair A. Nanjiani,Saima Rasheed,R. Sean Hill,R. Sean Hill,R. Sean Hill,Sofia B. Lizarraga,Sofia B. Lizarraga,Sofia B. Lizarraga,Danielle Gleason,Danielle Gleason,Danielle Gleason,Diya Sabbagh,Mustafa A. Salih,Fowzan S. Alkuraya,Christopher A. Walsh +38 more
TL;DR: Two autosomal-recessive “founder” mutations in the CC2D1A gene causing fully penetrant cognitive phenotypes, including mild-to-severe ID, ASD, as well as seizures, are presented, suggesting shared developmental mechanisms.
Journal ArticleDOI
A novel form of pontocerebellar hypoplasia maps to chromosome 7q11-21.
Anna Rajab,Ganeshwaran H. Mochida,Anthony D. Hill,Vijay S. Ganesh,Adria Bodell,A. Riaz,P. E. Grant,Yin Yao Shugart,Christopher A. Walsh +8 more
TL;DR: This report represents the first identification of a genetic locus for PCH, which the authors propose to call cerebellar atrophy with progressive microcephaly (CLAM), and this disorder maps to chromosome 7q11-21.