C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
Papers
More filters
Journal ArticleDOI
Prevalence and mechanisms of somatic deletions in single human neurons during normal aging and in DNA repair disorders
Junho Kim,August Yue Huang,Shelby L. Johnson,Jenny Lai,Laura Isacco,Ailsa M. Jeffries,Michael B. Miller,Michael A. Lodato,Christopher A. Walsh,Eunjung Lee +9 more
TL;DR: In this paper , the authors developed PhaseDel, a computational method to detect focal deletions and characterize underlying mechanisms in single-cell whole genome sequences (scWGS), and found that somatic deletions increased with age and in highly expressed genes in human brain.
Journal ArticleDOI
MIPP-Seq: ultra-sensitive rapid detection and validation of low-frequency mosaic mutations.
Ryan N. Doan,Ryan N. Doan,Michael B. Miller,Michael B. Miller,Sonia N. Kim,Sonia N. Kim,Rachel E. Rodin,Javier Ganz,Sara Bizzotto,Katherine S. Morillo,August Yue Huang,Reethika Digumarthy,Zachary Zemmel,Christopher A. Walsh +13 more
TL;DR: MIPP-Seq as discussed by the authors combines the power of ultra-deep sequencing and truly independent assays to quantitatively detect and measure extremely low allelic fractions (AAFs) using a combination of SNVs, insertions, and deletions at known allelic fraction in blood and brain derived DNA samples.
Journal ArticleDOI
Growth and Plasticity of Neural Connections
TL;DR: Although this book began as a summary of a meeting held by the Society of Experimental Biology, the topic became of such interest that the chapters were expanded to form bona fide reviews, and the list of contributors was expanded to include some workers not at the original meeting.
Posted ContentDOI
The polymicrogyria-associated GPR56 promoter preferentially drives gene expression in developing GABAergic neurons in common marmosets
Ayako Y. Murayama,Ken-ichiro Kuwako,Junko Okahara,Byoung-Il Bae,Masako Okuno,Hiromi Mashiko,Tomomi Shimogori,Christopher A. Walsh,Erika Sasaki,Hideyuki Okano +9 more
TL;DR: A possible pathogenic role for GABAergic neuron in the cerebral cortex of patients with GPR56 mutations is indicated by a transgenic marmoset line in which EGFP is expressed under the control of the human minimal e1m promoter.
Journal ArticleDOI
Neural development: identical twins separated at birth?
TL;DR: A combination of time-lapse analysis of developing brain slices in vitro and the cloning of genes involved in determining cell fate has demonstrated the remarkable similarities between early neurogenetic events in vertebrates and invertebrates.