C
Christopher A. Walsh
Researcher at Howard Hughes Medical Institute
Publications - 470
Citations - 62520
Christopher A. Walsh is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Cerebral cortex & Microcephaly. The author has an hindex of 123, co-authored 455 publications receiving 55874 citations. Previous affiliations of Christopher A. Walsh include University of Liverpool & Newcastle University.
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Journal ArticleDOI
Aberrant splicing of a mouse disabled homolog, mdab1, in the scrambler mouse.
Marcus L. Ware,Jeremy W. Fox,Jorge L. González,Nicole M Davis,Catherine Lambert de Rouvroit,Christopher J. Russo,Streamson C. Chua,André M. Goffinet,Christopher A. Walsh +8 more
TL;DR: The scrambler (scm) mouse shows abnormal cortical lamination that is indistinguishable from reeler, and genetic and physical mapping of scm identified yeast artificial chromosomes containing an exon of mdab1, a homolog of Drosophila disabled, which encodes a phosphoprotein that binds nonreceptor tyrosine kinases.
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Mutations in the X-linked filamin 1 gene cause periventricular nodular heterotopia in males as well as in females.
Volney L. Sheen,Peter H. Dixon,Jeremy W. Fox,Susan E. Hong,Lucy Kinton,Sanjay M. Sisodiya,John S. Duncan,François Dubeau,Ingrid E. Scheffer,Steven C. Schachter,Andrew Wilner,Ruth Henchy,Peter B. Crino,Kazuhiro Kamuro,Frances DiMario,Michel J. Berg,Ruben Kuzniecky,Andrew J. Cole,Edward B. Bromfield,Michael P. Biber,Donald L. Schomer,J. Wheless,Kenneth Silver,Ganeshwaran H. Mochida,Samuel F. Berkovic,F. Andermann,Eva Andermann,William B. Dobyns,Nicholas W. Wood,Christopher A. Walsh +29 more
TL;DR: The results demonstrate the sensitivity and specificity of DNA testing for FLN1 mutations and have important functional implications for models ofFLN1 protein function in neuronal migration.
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Mutations in PNKP cause microcephaly, seizures and defects in DNA repair
Jun Shen,Edward C. Gilmore,Edward C. Gilmore,Christine A Marshall,Mary Haddadin,John J. Reynolds,Wafaa Eyaid,Adria Bodell,Brenda J. Barry,Danielle Gleason,Kathryn Allen,Vijay S. Ganesh,Bernard S. Chang,Arthur Grix,R. Sean Hill,Meral Topçu,Keith W. Caldecott,A. James Barkovich,Christopher A. Walsh,Christopher A. Walsh,Christopher A. Walsh +20 more
TL;DR: A previously unknown autosomal recessive disease characterized by microcephaly, early-onset, intractable seizures and developmental delay (denoted MCSZ) is described and multiple mutations in PNKP (polynucleotide kinase 3′-phosphatase) that result in severe neurological disease are identified.
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Genetic Interactions between Doublecortin and Doublecortin-like Kinase in Neuronal Migration and Axon Outgrowth
Thomas A.S. Deuel,Judy S. Liu,Joseph C. Corbo,Seung-Yun Yoo,Lucy B. Rorke-Adams,Christopher A. Walsh +5 more
TL;DR: It is shown that mice mutant for both Dcx and Dclk demonstrate perinatal lethality, disorganized neocortical layering, and profound hippocampal cytoarchitectural disorganization, a process critical to both neuronal migration and axon outgrowth.
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Increased Neuronal Production, Enlarged Forebrains and Cytoarchitectural Distortions in β-Catenin Overexpressing Transgenic Mice
Anjen Chenn,Christopher A. Walsh +1 more
TL;DR: It is suggested that beta-Catenin can cause expansion of the precursor pool resulting in increased neuronal production and greater brain size and suggest a crucial role for beta-catenin in neuronal migration and cortical lamination.