Christopher A. Walsh

TL;DR: Autosomal recessive primary microcephaly is a potential model in which to research genes involved in human brain growth and neuroepithelial expression of the genes during prenatal neurogenesis and protein localization to the spindle poles of mitotic cells is found, suggesting that a centrosomal mechanism controls neuron number in the developing mammalian brain.

TL;DR: It is shown that the most common cause of MCPH is homozygous mutation of ASPM, the human ortholog of the Drosophila melanogaster abnormal spindle gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts.

TL;DR: Reelin inhibits migration of cortical neurons and enables detachment of neurons from radial glia and may arrest neuronal migration and promote normal cortical lamination by binding alpha3beta1 integrin and modulating integrin-mediated cellular adhesion.

TL;DR: It is found that the cerebrospinal fluid, which contacts this apical domain, has an age-dependent effect on proliferation, much of which is attributable to Igf2, but that CSF contains other signaling activities as well.

TL;DR: The existence of an intermediate neuronal precursor in the SVZ dedicated to the generation of upper layer neurons, marked specifically by Cux‐2 is supported, suggesting potential roles as determinants of the neuronal fate of the upper cortical layer neurons.