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Nan W. Hultgren
Researcher at University of California, Los Angeles
Publications - 6
Citations - 497
Nan W. Hultgren is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Angiogenesis & Endothelial stem cell. The author has an hindex of 4, co-authored 6 publications receiving 297 citations. Previous affiliations of Nan W. Hultgren include University of California, Irvine.
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Journal ArticleDOI
Consensus guidelines for the use and interpretation of angiogenesis assays
Patrycja Nowak-Sliwinska,Kari Alitalo,Elizabeth Allen,Andrey Anisimov,Alfred C. Aplin,Robert Auerbach,Hellmut G. Augustin,Hellmut G. Augustin,David O. Bates,Judy R. van Beijnum,R. Hugh F. Bender,Gabriele Bergers,Gabriele Bergers,Andreas Bikfalvi,Joyce Bischoff,Barbara C. Böck,Barbara C. Böck,Peter C. Brooks,Federico Bussolino,Bertan Cakir,Peter Carmeliet,Daniel Castranova,Anca Maria Cimpean,Ondine Cleaver,George Coukos,George E. Davis,Michele De Palma,Anna Dimberg,Ruud P.M. Dings,Valentin Djonov,Andrew C. Dudley,Neil Dufton,Sarah-Maria Fendt,Napoleone Ferrara,Marcus Fruttiger,Dai Fukumura,Bart Ghesquière,Bart Ghesquière,Yan Gong,Robert J. Griffin,Adrian L. Harris,Christopher C.W. Hughes,Nan W. Hultgren,M. Luisa Iruela-Arispe,Melita Irving,Rakesh K. Jain,Raghu Kalluri,Joanna Kalucka,Robert S. Kerbel,Jan Kitajewski,Ingeborg Klaassen,Hynda K. Kleinmann,Pieter Koolwijk,Elisabeth Kuczynski,Brenda R. Kwak,Koen Marien,Juan M. Melero-Martin,Lance L. Munn,Roberto F. Nicosia,Agnès Noël,Jussi Nurro,Anna-Karin Olsson,Tatiana V. Petrova,Kristian Pietras,Roberto Pili,Jeffrey W. Pollard,Mark J. Post,Paul H.A. Quax,Gabriel A. Rabinovich,Marius Raica,Anna M. Randi,Domenico Ribatti,Curzio Rüegg,Reinier O. Schlingemann,Reinier O. Schlingemann,Stefan Schulte-Merker,Lois E.H. Smith,Jonathan W. Song,Steven A. Stacker,Jimmy Stalin,Amber N. Stratman,Maureen Van de Velde,Victor W.M. van Hinsbergh,Peter B. Vermeulen,Johannes Waltenberger,Brant M. Weinstein,Hong Xin,Bahar Yetkin-Arik,Seppo Ylä-Herttuala,Mervin C. Yoder,Arjan W. Griffioen +90 more
TL;DR: In vivo, ex vivo, and in vitro bioassays that are available for the evaluation of angiogenesis are described and critical aspects that are relevant for their execution and proper interpretation are highlighted.
Journal ArticleDOI
Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis.
Nan W. Hultgren,Jennifer S. Fang,Mary Ziegler,Ricardo Ramirez,Duc T. T. Phan,Michaela M.S. Hatch,Katrina M. Welch-Reardon,Antonio E. Paniagua,Lin S. Kim,Nathan N. Shon,David S. Williams,Ali Mortazavi,Christopher C.W. Hughes +12 more
TL;DR: It is found that Slug upregulation in angiogenic endothelial cells (EC) regulates an EMT-like suite of target genes, and suppresses Dll4-Notch signaling thereby promoting VEGFR2 expression.
Journal ArticleDOI
Quantification of cristae architecture reveals time-dependent characteristics of individual mitochondria
Mayuko Segawa,Dane M. Wolf,Dane M. Wolf,Nan W. Hultgren,David S. Williams,Alexander M. van der Bliek,David B. Shackelford,Marc Liesa,Orian S. Shirihai +8 more
TL;DR: A novel, machine-learning approach to quantify cristae density and architecture in live-cell super-resolution imaging characterizes the ultrastructural parameters of individual mitochondria over time and shows that machine learning represents a compelling new strategy for quantifyingcristae in living cells.
Journal ArticleDOI
3D surface analysis of hippocampal microvasculature in the irradiated brain
Brianna M. Craver,Munjal M. Acharya,Barrett D. Allen,Sarah N. Benke,Nan W. Hultgren,Janet E. Baulch,Charles L. Limoli +6 more
TL;DR: The utility of two distinct methodologies for quantifying early and late radiation injury in CNS microvasculature are demonstrated, which may be contributory if not causal to any number of neurocognitive side effects that manifest in cancer patients following cranial radiotherapy.
Journal ArticleDOI
Regulation of Partial and Reversible Endothelial-to-Mesenchymal Transition in Angiogenesis.
TL;DR: In this article, the authors discuss possible regulatory mechanisms that may control the EndoMT program to dictate whether cells undergo complete or partial mesenchymal transition, and further consider how these pathways might be targeted therapeutically in cancer.