C
Christopher P. Arthur
Researcher at Genentech
Publications - 33
Citations - 1463
Christopher P. Arthur is an academic researcher from Genentech. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 13, co-authored 27 publications receiving 1063 citations. Previous affiliations of Christopher P. Arthur include Scripps Research Institute & FEI Company.
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Journal ArticleDOI
Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.
Radhika Subramanian,Elizabeth M. Wilson-Kubalek,Christopher P. Arthur,Matthew J. Bick,Elizabeth A. Campbell,Seth A. Darst,Ronald A. Milligan,Tarun M. Kapoor +7 more
TL;DR: The data show how MAP65s, by combining structural flexibility and rigidity, tune microtubule associations to establish crosslinks that selectively "mark" antiparallel overlap in dynamic cytoskeletal networks.
Journal ArticleDOI
An Unbiased Screen for Human Cytomegalovirus Identifies Neuropilin-2 as a Central Viral Receptor.
Nadia Martinez-Martin,Jessica Marcandalli,Christine S. Huang,Christopher P. Arthur,Michela Perotti,Mathilde Foglierini,Hoangdung Ho,Annie M. Dosey,Stephanie Shriver,Jian Payandeh,Alexander Leitner,Antonio Lanzavecchia,Antonio Lanzavecchia,Laurent Perez,Claudio Ciferri +14 more
TL;DR: A library consisting of most single transmembrane human receptors is built and a workflow for unbiased and high-sensitivity detection of receptor-ligand interactions is implemented to elucidate the long-sought receptor of human cytomegalovirus (HCMV), the leading viral cause of congenital birth defects.
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Structural basis of α-scorpion toxin action on Nav channels
Thomas Clairfeuille,Alexander Cloake,Alexander Cloake,Daniel T. Infield,José P. Llongueras,Christopher P. Arthur,Zhong Rong Li,Yuwen Jian,Marie-France Martin-Eauclaire,Pierre E. Bougis,Claudio Ciferri,Christopher A. Ahern,Frank Bosmans,David H. Hackos,Alexis Rohou,Jian Payandeh +15 more
TL;DR: Structures reveal how activation of voltage-gated sodium channels causes conformational changes in a voltage-sensor domain, leading to fast inactivation, and pharmacological trapping of VSD4 reveals state-dependent interactions of gating charges from the S4 helix and S4-S5 linker.
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Autapses and networks of hippocampal neurons exhibit distinct synaptic transmission phenotypes in the absence of synaptotagmin I.
TL;DR: Comparing synaptic transmission in two different hippocampal neuron preparations found that aspects of synaptic transmission differ between autaptic and dissociated cultures, and the synaptic transmission phenotype, resulting from loss of syt-I, is dictated by the connectivity of neurons.
ComponentDOI
Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin.
Hui Xu,Tianbo Li,Alexis Rohou,Christopher P. Arthur,Foteini Tzakoniati,Evera Wong,Alberto Estevez,Christine Kugel,Yvonne Franke,Jun Chen,Claudio Ciferri,David H. Hackos,Christopher M. Koth,Jian Payandeh +13 more
TL;DR: ProTx2 from the Peruvian green velvet tarantula is an inhibitor cystine-knot peptide and selective antagonist of the human Nav1.7 channel, providing a structural framework for activation gating in voltage-gated ion channels.