Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.
Radhika Subramanian,Elizabeth M. Wilson-Kubalek,Christopher P. Arthur,Matthew J. Bick,Elizabeth A. Campbell,Seth A. Darst,Ronald A. Milligan,Tarun M. Kapoor +7 more
TLDR
The data show how MAP65s, by combining structural flexibility and rigidity, tune microtubule associations to establish crosslinks that selectively "mark" antiparallel overlap in dynamic cytoskeletal networks.About:
This article is published in Cell.The article was published on 2010-08-06 and is currently open access. It has received 293 citations till now. The article focuses on the topics: Microtubule nucleation & Antiparallel (biochemistry).read more
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Cytokinesis in Animal Cells
TL;DR: The cytoskeletal structures, factors, and signaling pathways that orchestrate this robust and yet highly dynamic process in animal cells, known as cytokinesis, are described.
Journal ArticleDOI
Molecular control of animal cell cytokinesis
TL;DR: How recent insights have led to refined models of the distinct steps of animal cell cytokinesis are discussed, including anaphase spindle reorganization, division plane specification, actomyosin ring assembly and contraction, and abscission.
Journal ArticleDOI
Cytokinetic Abscission: Molecular Mechanisms and Temporal Control
Beata Mierzwa,Daniel W. Gerlich +1 more
TL;DR: A brief overview of early cytokinesis events in animal cells is provided and in depth recently emerging models for the assembly and function of the abscission machinery and its temporal coordination with chromosome segregation are covered.
Journal ArticleDOI
Microtubule-Associated Proteins: Structuring the Cytoskeleton.
Satish Bodakuntla,A S Jijumon,A S Jijumon,Cristopher Villablanca,Christian Gonzalez-Billault,Carsten Janke,Carsten Janke +6 more
TL;DR: This work provides a comprehensive view on the currently known microtubule-associated proteins in mammals and discusses their molecular mechanisms and functions, as well as their physiological role and links to pathologies.
Journal ArticleDOI
The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway
Jianxiang Chen,Muthukumar Rajasekaran,Hongping Xia,Xiaoqian Zhang,Shik Nie Kong,Karthik Sekar,Veerabrahma Pratap Seshachalam,Amudha Deivasigamani,Brian K. P. Goh,London L.P.J. Ooi,Wanjin Hong,Kam M. Hui +11 more
TL;DR: It is demonstrated that the expression and distribution of PRC1 is dynamically regulated by Wnt3a signalling, a novel Wnt target that functions in a positive feedback loop that reinforces Wnt signalling to promote early HCC recurrence.
References
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UCSF Chimera--a visualization system for exploratory research and analysis.
Eric F. Pettersen,Thomas D. Goddard,Conrad C. Huang,Gregory S. Couch,Daniel M. Greenblatt,Elaine C. Meng,Thomas E. Ferrin +6 more
TL;DR: Two unusual extensions are presented: Multiscale, which adds the ability to visualize large‐scale molecular assemblies such as viral coats, and Collaboratory, which allows researchers to share a Chimera session interactively despite being at separate locales.
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Processing of X-ray diffraction data collected in oscillation mode
Zbyszek Otwinowski,Wladek Minor +1 more
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