Simon Walker-Samuel

TL;DR: Experts assembled to review, debate and summarize the challenges of IB validation and qualification produced 14 key recommendations for accelerating the clinical translation of IBs, which highlight the role of parallel (rather than sequential) tracks of technical validation, biological/clinical validation and assessment of cost-effectiveness.

TL;DR: The results of this study suggest that glucoCEST has potential as a useful and cost-effective method for characterizing disease and assessing response to therapy in the clinic.

TL;DR: A novel technique called VERDICT (Vascular, Extracellular and Restricted Diffusion for Cytometry in Tumors) is presented to quantify and map histologic features of tumors in vivo, establishing it as a noninvasive method to monitor and stratify treatment responses.

TL;DR: Simulations of DCE-MRI data were used to investigate the relationship between IAUGC and the parameters K(trans) (transfer constant), v(e) (fractional extravascular extracellular volume) and v(p) ( fractional plasma volume), and it is shown that IAUGC is a mixed parameter that can display correlation with K( trans), v-e and v-p and ultimately has an intractable relationship with all three.

TL;DR: A general modelling framework for defining compact functional forms to describe vascular input functions is described and three models defined by four parameters, using exponential, gamma-variate and cosine descriptions of the bolus, are described and their properties investigated using simulations.