C
Claire Hivroz
Researcher at PSL Research University
Publications - 61
Citations - 3470
Claire Hivroz is an academic researcher from PSL Research University. The author has contributed to research in topics: T cell & Immunological synapse. The author has an hindex of 28, co-authored 61 publications receiving 2989 citations. Previous affiliations of Claire Hivroz include Curie Institute & French Institute of Health and Medical Research.
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Journal ArticleDOI
STIM1 Mutation Associated with a Syndrome of Immunodeficiency and Autoimmunity
Capucine Picard,Christie Ann McCarl,Alexander Papolos,Sara Khalil,Kevin Lüthy,Claire Hivroz,Claire Hivroz,Francoise LeDeist,Francoise LeDeist,Francoise LeDeist,Frédéric Rieux-Laucat,Frédéric Rieux-Laucat,Gideon Rechavi,Anjana Rao,Alain Fischer,Alain Fischer,Alain Fischer,Stefan Feske +17 more
TL;DR: Three siblings from one kindred with a clinical syndrome of immunodeficiency, hepatosplenomegaly, autoimmune hemolytic anemia, thrombocytopenia, muscular hypotonia, and defective enamel dentition have a homozygous nonsense mutation in STIM1 that abrogates expression ofSTIM1 and Ca(2+) influx.
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MAIT cells detect and efficiently lyse bacterially-infected epithelial cells.
Lionel Le Bourhis,Mathilde Dusseaux,Armelle Bohineust,Stéphanie Bessoles,Emmanuel Martin,Virginie Premel,Maxime Coré,David Sleurs,Nacer-Eddine Serriari,Emmanuel Treiner,Claire Hivroz,Philippe J. Sansonetti,Marie-Lise Gougeon,Claire Soudais,Olivier Lantz +14 more
TL;DR: In humans, MAIT cells are the most abundant T cell subset able to detect and kill bacteria infected cells, and are activated in human volunteers receiving an attenuated strain of Shigella dysenteriae-1 tested as a potential vaccine.
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Cytotoxic T Cells Use Mechanical Force to Potentiate Target Cell Killing.
Roshni Basu,Benjamin M. Whitlock,Julien Husson,Audrey Le Floc’h,Weiyang Jin,Alon Oyler-Yaniv,Farokh Dotiwala,Grégory Giannone,Claire Hivroz,Nicolas Biais,Judy Lieberman,Lance C. Kam,Morgan Huse +12 more
TL;DR: An unappreciated physical dimension to lymphocyte function is revealed and cells use mechanical forces to control the activity of outgoing chemical signals and data indicate that CTLs coordinate perforin release and force exertion in space and time.
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Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes.
Nathalie Demotte,Nathalie Demotte,Vincent Stroobant,Vincent Stroobant,Pierre J. Courtoy,Patrick Van Der Smissen,Didier Colau,Didier Colau,Immanuel F. Luescher,Claire Hivroz,Julie Nicaise,Julie Nicaise,Jean-Luc Squifflet,Michel Mourad,Danièle Godelaine,Danièle Godelaine,Thierry Boon,Thierry Boon,Pierre van der Bruggen,Pierre van der Bruggen +19 more
TL;DR: These lymphocytes recovered effector functions and TCR-CD8 colocalization after ex vivo treatment with galectin disaccharide ligands, suggesting the separation of TCR and CD8 molecules could be one major mechanism of anergy in tumors and other chronic stimulation conditions.
Journal ArticleDOI
Force generation upon T cell receptor engagement.
Julien Husson,Karine Chemin,Karine Chemin,Armelle Bohineust,Armelle Bohineust,Claire Hivroz,Claire Hivroz,Nelly Henry,Nelly Henry,Nelly Henry +9 more
TL;DR: The first quantified description of force generation sequence upon local bidimensional engagement of TCR-CD3 is provided and its potential role in a T cell mechanically-regulated activation process is discussed.