D
Daisy Hjelmqvist
Researcher at Harvard University
Publications - 13
Citations - 424
Daisy Hjelmqvist is an academic researcher from Harvard University. The author has contributed to research in topics: Plasmodium falciparum & Lone pair. The author has an hindex of 7, co-authored 13 publications receiving 326 citations. Previous affiliations of Daisy Hjelmqvist include Stockholm University & Karolinska Institutet.
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Journal ArticleDOI
Infected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
Pierre-Yves Mantel,Daisy Hjelmqvist,Michael Walch,Solange Kharoubi-Hess,Sandra K. Nilsson,Deepali Ravel,Marina Ribeiro,Christof Grüring,Siyuan Ma,Prasad K. Padmanabhan,Alexander J. Trachtenberg,Johan Ankarklev,Nicolas M. B. Brancucci,Nicolas M. B. Brancucci,Curtis Huttenhower,Manoj T. Duraisingh,Ionita Ghiran,Winston Patrick Kuo,Luis Filgueira,Roberta Martinelli,Matthias Marti,Matthias Marti +21 more
TL;DR: These findings provide a mechanistic link between EVs and vascular dysfunction during malaria infection and show that EVs are efficiently internalized by endothelial cells, where the miRNA-Argonaute 2 complexes modulate target gene expression and barrier properties.
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Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum
Sonia Gulati,Eric H. Ekland,Kelly V. Ruggles,Robin B. Chan,Bamini Jayabalasingham,Bowen Zhou,Pierre-Yves Mantel,Marcus C. S. Lee,Natasha Spottiswoode,Olivia Coburn-Flynn,Daisy Hjelmqvist,Tilla S. Worgall,Matthias Marti,Gilbert Di Paolo,David A. Fidock +14 more
TL;DR: These studies highlight the interplay between host and parasite lipid metabolism and provide a comprehensive analysis of P. falciparum lipids with candidate pathways for drug discovery efforts.
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Shared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles
Karell G. Pellé,Rays H. Y. Jiang,Rays H. Y. Jiang,Pierre-Yves Mantel,Yu-Ping Xiao,Daisy Hjelmqvist,Gina M Gallego-Lopez,Audrey O.T. Lau,Byung-Ho Kang,David R. Allred,Matthias Marti +10 more
TL;DR: This work functionally demonstrate an analogous host‐targeting pathway involving organellar staging prior to secretion in the related bovine parasite, Babesia bovis, a parasite that destroys the PVM shortly after invasion.
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Exploring parasite heterogeneity using single-cell RNA-seq reveals a gene signature among sexual stage Plasmodium falciparum parasites
Mtakai Ngara,Mia Palmkvist,Sven Sagasser,Daisy Hjelmqvist,Åsa K. Björklund,Mats Wahlgren,Johan Ankarklev,Johan Ankarklev,Johan Ankarklev,Rickard Sandberg,Rickard Sandberg +10 more
TL;DR: A capillary‐based platform for cell isolation with single‐cell RNA‐sequencing to transcriptionally profile 165 single infected red blood cells during the intra‐erythrocytic developmental cycle (IDC) and a gene signature is uncovered that can successfully discriminate between developing asexual and sexual stage parasites at cellular resolution.
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Anti-Peroxyl Radical Quality and Antibacterial Properties of Rooibos Infusions and Their Pure Glycosylated Polyphenolic Constituents
Madeline J. Simpson,Daisy Hjelmqvist,Camilo López-Alarcón,Nadja Karamehmedovic,Thomas G. Minehan,Akop Yepremyan,Baback Salehani,Eduardo Lissi,Elizabeth Joubert,Klas I. Udekwu,Emilio I. Alarcon +10 more
TL;DR: The anti-peroxyl radical quality of two aqueous rooibos infusions and solutions of their most abundant glycosylated polyphenols was evaluated and it was observed that the artificial infusions showed greater antioxidant quality than the latter infusions, reaching values close to those reported for tea infusions.