J
John Connolly
Researcher at University of Pennsylvania
Publications - 42
Citations - 2512
John Connolly is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: Medicine & Population. The author has an hindex of 12, co-authored 18 publications receiving 2053 citations. Previous affiliations of John Connolly include Children's Hospital of Philadelphia.
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Journal ArticleDOI
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis.
Daniel I. Swerdlow,Michael V. Holmes,Karoline Kuchenbaecker,Engmann Jel.,Tina Shah,Reecha Sofat,Yiran Guo,C Chung,Anne Peasey,Roman Pfister,Simon P. Mooijaart,Helen Ireland,Maarten Leusink,Claudia Langenberg,KaWah Li,Jutta Palmen,Phil Howard,Jackie A. Cooper,Fotios Drenos,John Hardy,Mike A. Nalls,Yun Li,Gordon D.O. Lowe,Marlene C. W. Stewart,S. J. Bielinski,Julian Peto,Nicholas J. Timpson,John Gallacher,Malcolm G. Dunlop,Richard S. Houlston,Ian Tomlinson,Ioanna Tzoulaki,Jian'an Luan,Boer Jma.,Nita G. Forouhi,N. C. Onland-Moret,Y. T. van der Schouw,Renate B. Schnabel,Jaroslav A. Hubacek,Růžena Kubínová,Migle Baceviciene,Abdonas Tamosiunas,Andrzej Pajak,Roman Topor-Madry,Sofia Malyutina,Damiano Baldassarre,Bengt Sennblad,Elena Tremoli,U de Faire,Luigi Ferrucci,S Bandenelli,Tetsu Tanaka,James F. Meschia,AB Singleton,Gerjan Navis,I. Mateo Leach,Bakker Sjl.,Ron T. Gansevoort,Ian Ford,Stephen E. Epstein,Mary-Susan Burnett,Joe Devaney,Johan Wouter Jukema,Westendorp Rgj.,G Jan de Borst,Y. van der Graaf,P A de Jong,Mailand-van der Zee A-H.,Olaf H. Klungel,A. de Boer,P. A. Doevendans,Jeffrey W. Stephens,Charles B. Eaton,Jennifer G. Robinson,JoAnn E. Manson,F G Fowkes,Timothy M. Frayling,Jenna Price,Peter H. Whincup,Richard W Morris,Debbie A Lawlor,George Davey Smith,Yoav Ben-Shlomo,Susan Redline,Leslie A. Lange,Meena Kumari,Nicholas J. Wareham,Verschuren Wmm.,Emelia J. Benjamin,John C. Whittaker,Anders Hamsten,Frank Dudbridge,Delaney Jac.,Andrew Wong,Diana Kuh,Rebecca Hardy,Berta Almoguera Castillo,John Connolly,P. van der Harst,Eric J. Brunner,Michael Marmot,Christina L. Wassel,Steve E. Humphries,P.J. Talmud,Mika Kivimäki,Folkert W. Asselbergs,Mikhail I. Voevoda,Martin Bobak,Hynek Pikhart,James G. Wilson,Hakon Hakonarson,Alexander P. Reiner,Brendan J. Keating,Naveed Sattar,Aroon D. Hingorani,Juan P. Casas +115 more
TL;DR: IL6R blockade could provide a novel therapeutic approach to prevention of coronary heart disease that warrants testing in suitably powered randomised trials and could help to validate and prioritise novel drug targets or to repurpose existing agents and targets for new therapeutic uses.
Journal ArticleDOI
The Electronic Medical Records and Genomics (eMERGE) Network: past, present, and future
Omri Gottesman,Helena Kuivaniemi,Gerard Tromp,W. Andrew Faucett,Rongling Li,Teri A. Manolio,Saskia C. Sanderson,Joseph L. Kannry,Randi E. Zinberg,Melissa A. Basford,Murray H. Brilliant,David J. Carey,Rex L. Chisholm,Christopher G. Chute,John Connolly,David R. Crosslin,Joshua C. Denny,Carlos J. Gallego,Jonathan L. Haines,Hakon Hakonarson,John B. Harley,Gail P. Jarvik,Isaac S. Kohane,Iftikhar J. Kullo,Eric B. Larson,Catherine A. McCarty,Marylyn D. Ritchie,Dan M. Roden,Maureen E. Smith,Erwin P. Bottinger,Marc S. Williams +30 more
TL;DR: The evolution, accomplishments, opportunities, and challenges of the network are described, from its inception as a five- group consortium focused on genotype–phenotype associations for genomic discovery to its current form as a nine-group consortium pivoting toward the implementation of genomic medicine.
Journal ArticleDOI
Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases
Yun Li,Jin Li,Sihai Dave Zhao,Sihai Dave Zhao,Jonathan P. Bradfield,Frank D. Mentch,S. Melkorka Maggadottir,Cuiping Hou,Debra J. Abrams,Diana Chang,Feng Gao,Yiran Guo,Zhi Wei,John Connolly,Christopher J. Cardinale,Marina Bakay,Joseph T. Glessner,Dong Li,Charlly Kao,Kelly A. Thomas,Haijun Qiu,Rosetta M. Chiavacci,Cecilia E. Kim,Fengxiang Wang,James Snyder,Marylyn D Richie,Berit Flatø,Øystein Førre,Lee A. Denson,Susan D. Thompson,Mara L. Becker,Stephen L. Guthery,Anna Latiano,Elena E. Perez,Elena S. Resnick,Richard K Russell,David C. Wilson,Mark S. Silverberg,Vito Annese,Benedicte A. Lie,Marilynn Punaro,Marla Dubinsky,Dimitri S. Monos,Caterina Strisciuglio,Annamaria Staiano,Erasmo Miele,Subra Kugathasan,Justine A. Ellis,Jane E Munro,Kathleen E. Sullivan,Carol Wise,Helen Chapel,Charlotte Cunningham-Rundles,Struan F.A. Grant,Jordan S. Orange,Patrick M. A. Sleiman,Edward M. Behrens,Anne M. Griffiths,Jack Satsangi,Terri H. Finkel,Alon Keinan,Eline T. Luning Prak,Constantin Polychronakos,Robert N. Baldassano,Hongzhe Li,Brendan J. Keating,Hakon Hakonarson +66 more
TL;DR: Network and protein-interaction analyses demonstrated converging roles for the signaling pathways of type 1, 2 and 17 helper T cells (TH1, TH2 and TH17), JAK-STAT, interferon and interleukin in multiple autoimmune diseases.
Journal ArticleDOI
Design and anticipated outcomes of the eMERGE-PGx project: a multicenter pilot for preemptive pharmacogenomics in electronic health record systems.
Laura J. Rasmussen-Torvik,Sarah C. Stallings,Adam S. Gordon,Berta Almoguera,Melissa A. Basford,Suzette J. Bielinski,Ariel Brautbar,Murray H. Brilliant,David Carrell,John Connolly,David R. Crosslin,Kimberly F. Doheny,Carlos J. Gallego,Omri Gottesman,Daniel Seung Kim,Kathleen A. Leppig,Rongling Li,Simon Lin,Shannon Manzi,Ana R. Mejia,Jennifer A. Pacheco,Vivian Pan,Jyotishman Pathak,Cassandra Perry,Josh F. Peterson,Cynthia A. Prows,James D. Ralston,Luke V. Rasmussen,Marylyn D. Ritchie,Senthilkumar Sadhasivam,Senthilkumar Sadhasivam,Stuart A. Scott,Maureen E. Smith,Aida Vega,Alexander A. Vinks,Alexander A. Vinks,Simona Volpi,Wendy A. Wolf,Erwin P. Bottinger,Rex L. Chisholm,Christopher G. Chute,Jonathan L. Haines,John B. Harley,John B. Harley,Brendan J. Keating,Ingrid A. Holm,Ingrid A. Holm,Iftikhar J. Kullo,Gail P. Jarvik,Eric B. Larson,Teri A. Manolio,Catherine A. McCarty,Deborah A. Nickerson,Steven E. Scherer,Marc S. Williams,Dan M. Roden,Joshua C. Denny +56 more
TL;DR: The design and initial implementation of the eMERGE‐PGx project is described, including site‐specific project implementation and anticipated products, including genetic variant and phenotype data repositories, novel variant association studies, clinical decision support modules, clinical and process outcomes, approaches to managing incidental findings, and patient and clinician education methods.
Journal ArticleDOI
Association of Arrhythmia-Related Genetic Variants With Phenotypes Documented in Electronic Medical Records
Sara L. Van Driest,Quinn S. Wells,Sarah C. Stallings,William S. Bush,William S. Bush,Adam S. Gordon,Deborah A. Nickerson,Jerry H. Kim,David R. Crosslin,Gail P. Jarvik,David Carrell,James D. Ralston,Eric B. Larson,Suzette J. Bielinski,Janet E. Olson,Zi Ye,Iftikhar J. Kullo,Noura S. Abul-Husn,Stuart A. Scott,Erwin P. Bottinger,Berta Almoguera,John Connolly,Rosetta M. Chiavacci,Hakon Hakonarson,Laura J. Rasmussen-Torvik,Vivian Pan,Stephen D. Persell,Maureen E. Smith,Rex L. Chisholm,Terrie Kitchner,Max M. He,Murray H. Brilliant,John R. Wallace,Kimberly F. Doheny,M. Benjamin Shoemaker,Rongling Li,Teri A. Manolio,Thomas E. Callis,Daniela Macaya,Marc S. Williams,David J. Carey,Jamie D. Kapplinger,Michael J. Ackerman,Marylyn D. Ritchie,Marylyn D. Ritchie,Joshua C. Denny,Dan M. Roden +46 more
TL;DR: There was low concordance in designating SCN5A and KCNH2 variants as pathogenic in individuals recruited for nonantiarrhythmic drug exposure phenotypes, and these findings raise questions about the implications of notifying patients of incidental genetic findings.