S
Silke Kropp
Researcher at German Cancer Research Center
Publications - 41
Citations - 3569
Silke Kropp is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 32, co-authored 40 publications receiving 3434 citations.
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Journal ArticleDOI
A common coding variant in CASP8 is associated with breast cancer risk
Angela Cox,Alison M. Dunning,Montserrat Garcia-Closas,Sabapathy P. Balasubramanian,Malcolm W.R. Reed,Karen A. Pooley,Serena Scollen,Caroline Baynes,Bruce A.J. Ponder,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Melissa C. Southey,John L. Hopper,Margaret R. E. McCredie,Graham G. Giles,Olivia Fletcher,Nichola Johnson,Isabel dos Santos Silva,Lorna Gibson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,Diana Torres,Ute Hamann,Christina Justenhoven,Christina Justenhoven,Hiltrud Brauch,Hiltrud Brauch,Jenny Chang-Claude,Silke Kropp,Angela Risch,Shan Wang-Gohrke,Peter Schürmann,Natalia Bogdanova,Thilo Dörk,Rainer Fagerholm,Kirsimari Aaltonen,Carl Blomqvist,Heli Nevanlinna,Sheila Seal,Anthony Renwick,Michael R. Stratton,Nazneen Rahman,Suleeporn Sangrajrang,David J. Hughes,Fabrice Odefrey,Paul Brennan,Amanda B. Spurdle,Georgia Chenevix-Trench,Jonathan Beesley,Arto Mannermaa,Jaana M. Hartikainen,Vesa Kataja,Veli-Matti Kosma,Fergus J. Couch,Janet E. Olson,Ellen L. Goode,Annegien Broeks,Marjanka K. Schmidt,Frans B. L. Hogervorst,Laura J. van't Veer,Daehee Kang,Keun-Young Yoo,Dong Young Noh,Sei Hyun Ahn,Sara Wedrén,Per Hall,Yen-Ling Low,Jianjun Liu,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,Alice J. Sigurdson,Alice J. Sigurdson,Denise L. Stredrick,Denise L. Stredrick,Bruce H. Alexander,Bruce H. Alexander,Jeffery P. Struewing,Jeffery P. Struewing,Paul D.P. Pharoah,Douglas F. Easton +84 more
TL;DR: It is demonstrated that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies, as well as the need for further studies to confirm putative genetic associations with breast cancer.
Journal ArticleDOI
Heterogeneity of Breast Cancer Associations with Five Susceptibility Loci by Clinical and Pathological Characteristics
Montserrat Garcia-Closas,Per Hall,Heli Nevanlinna,Karen A. Pooley,Jonathan J. Morrison,Douglas A. Richesson,Stig E. Bojesen,Børge G. Nordestgaard,C K Axelsson,José Ignacio Arias,Roger L. Milne,Gloria Ribas,Anna González-Neira,Javier Benitez,P. Zamora,Hiltrud Brauch,Hiltrud Brauch,Christina Justenhoven,Christina Justenhoven,Ute Hamann,Yon Ko,Thomas Bruening,Susanne Haas,Thilo Dörk,Peter Schürmann,Peter Hillemanns,Natalia Bogdanova,Michael Bremer,Johann H. Karstens,Rainer Fagerholm,Kirsimari Aaltonen,Kristiina Aittomäki,Karl von Smitten,Carl Blomqvist,Arto Mannermaa,Matti Uusitupa,Matti Eskelinen,Maria Tengström,Veli-Matti Kosma,V. Kataja,Georgia Chenevix-Trench,Amanda B. Spurdle,Jonathan Beesley,Xiaoqing Chen,Peter Devilee,Christi J. van Asperen,Catharina E. Jacobi,Rob A. E. M. Tollenaar,Petra E A Huijts,Jan G. M. Klijn,Jenny Chang-Claude,Silke Kropp,Tracy Slanger,Dieter Flesch-Janys,Elke Mutschelknauss,Ramona Salazar,Shan Wang-Gohrke,Fergus J. Couch,Ellen L. Goode,Janet E. Olson,Celine M. Vachon,Zachary S. Fredericksen,Graham G. Giles,Laura Baglietto,Gianluca Severi,John L. Hopper,Dallas R. English,Melissa C. Southey,Christopher A. Haiman,Brian E. Henderson,Laurence N. Kolonel,Loic Le Marchand,Daniel O. Stram,David J. Hunter,Susan E. Hankinson,David G. Cox,Rulla M. Tamimi,Peter Kraft,Mark E. Sherman,Stephen J. Chanock,Jolanta Lissowska,Louise A. Brinton,Beata Peplonska,Maartje J. Hooning,Han Meijers-Heijboer,J. Margriet Collée,Ans M.W. van den Ouweland,André G. Uitterlinden,Jianjun Liu,Yen Lin Low,Li Yuqing,Keith Humphreys,Kamila Czene,Angela Cox,Sabapathy P. Balasubramanian,Simon S. Cross,Malcolm W.R. Reed,Fiona M. Blows,Kristy Driver,Alison M. Dunning,Jonathan Tyrer,Bruce A.J. Ponder,Suleeporn Sangrajrang,Paul Brennan,James McKay,Fabrice Odefrey,Valerie Gabrieau,Alice J. Sigurdson,Michele M. Doody,J. P. Struewing,Bruce H. Alexander,Douglas F. Easton,Paul D.P. Pharoah +112 more
TL;DR: The findings show that common genetic variants influence the pathological subtype of breast cancer and provide further support for the hypothesis that ER-positive and ER-negative disease are biologically distinct.
Journal ArticleDOI
Serum 25-hydroxyvitamin D and risk of post-menopausal breast cancer--results of a large case-control study
Sascha Abbas,Jakob Linseisen,Tracy Slanger,Silke Kropp,Elke Mutschelknauss,Dieter Flesch-Janys,Jenny Chang-Claude +6 more
TL;DR: A protective effect for post-menopausal breast cancer through a better vitamin D supply as characterized by serum 25(OH)D measurement is suggested, with a stronger inverse association in women with low serum 25-hydroxyvitamin D concentrations (<50 nM).
Journal ArticleDOI
Association between Polymorphisms in the DNA Repair Genes, XRCC1, APE1, and XPD and Acute Side Effects of Radiotherapy in Breast Cancer Patients
Jenny Chang-Claude,Odilia Popanda,Xiang-Lin Tan,Silke Kropp,Irmgard Helmbold,Dietrich von Fournier,Wulf Haase,Marie Luise Sautter-Bihl,Frederik Wenz,Peter Schmezer,Christine B. Ambrosone +10 more
TL;DR: The XRCC1 399Gln or APE1 148Glu alleles may be protective against the development of acute side effects after radiotherapy in patients with normal weight, as well as compared with homozygote carriers of the wild-type allele in both genes.
Journal ArticleDOI
Predictive factors for late normal tissue complications following radiotherapy for breast cancer.
Carmen Lilla,Christine B. Ambrosone,Silke Kropp,Irmgard Helmbold,Peter Schmezer,Dietrich von Fournier,Wulf Haase,Marie-Luise Sautter-Bihl,Frederik Wenz,Jenny Chang-Claude +9 more
TL;DR: Several factors other than radiation dose that may predispose to late complications following radiotherapy are revealed, including smoking and increasing age of the patient.