D
David M. Jaffe
Researcher at University of California, San Francisco
Publications - 101
Citations - 10686
David M. Jaffe is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Emergency department & Poison control. The author has an hindex of 34, co-authored 97 publications receiving 9347 citations. Previous affiliations of David M. Jaffe include Washington University in St. Louis & University of Maryland, Baltimore.
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Journal ArticleDOI
Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples
Kristian Cibulskis,Michael S. Lawrence,Scott L. Carter,Andrey Sivachenko,David M. Jaffe,Carrie Sougnez,Stacey Gabriel,Matthew Meyerson,Matthew Meyerson,Eric S. Lander,Eric S. Lander,Eric S. Lander,Gad Getz,Gad Getz +13 more
TL;DR: The MuTect algorithm for calling somatic point mutations enables subclonal analysis of the whole-genome or whole-exome sequencing data being generated in large-scale cancer genomics projects as discussed by the authors.
Journal ArticleDOI
Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype
Olivier Jaillon,Jean-Marc Aury,Frédéric Brunet,Jean-Louis Petit,Nicole Stange-Thomann,Evan Mauceli,Laurence Bouneau,Cécile Fischer,Catherine Ozouf-Costaz,Alain Bernot,Sophie Nicaud,David M. Jaffe,Sheila Fisher,Georges Lutfalla,Carole Dossat,Béatrice Segurens,Corinne Dasilva,Marcel Salanoubat,Michael Levy,Nathalie Boudet,Sergi Castellano,Véronique Anthouard,Claire Jubin,Vanina Castelli,Michael Katinka,Benoit Vacherie,Christian Biémont,Zineb Skalli,Laurence Cattolico,Julie Poulain,Véronique de Berardinis,Corinne Cruaud,Simone Duprat,Philippe Brottier,Jean-Pierre Coutanceau,Jérôme Gouzy,Genís Parra,Guillaume Lardier,Charles Chapple,Kevin McKernan,Paul A. McEwan,Stephanie Bosak,Manolis Kellis,Jean-Nicolas Volff,Roderic Guigó,Michael C. Zody,Jill P. Mesirov,Kerstin Lindblad-Toh,Bruce W. Birren,Chad Nusbaum,Daniel Kahn,Marc Robinson-Rechavi,Vincent Laudet,Vincent Schächter,Francis Quetier,William Saurin,Claude Scarpelli,Patrick Wincker,Eric S. Lander,Eric S. Lander,Jean Weissenbach,Hugues Roest Crollius,Hugues Roest Crollius +62 more
TL;DR: Genome analysis provides a greatly improved fish gene catalogue, including identifying key genes previously thought to be absent in fish, and reconstructs much of the evolutionary history of ancient and recent chromosome rearrangements leading to the modern human karyotype.
Journal ArticleDOI
Genome sequence of Aedes aegypti, a major arbovirus vector
Vishvanath Nene,Jennifer R. Wortman,Daniel Lawson,Brian J. Haas,Chinnappa D. Kodira,Zhijian Jake Tu,Brendan J. Loftus,Zhiyong Xi,Karyn Megy,Manfred Grabherr,Quinghu Ren,Evgeny M. Zdobnov,Neil F. Lobo,Kathryn S. Campbell,Susan E. Brown,Maria de Fatima Bonaldo,Jingsong Zhu,Steven P. Sinkins,David G. Hogenkamp,Paolo Amedeo,Peter Arensburger,Peter W. Atkinson,Shelby L. Bidwell,Jim Biedler,Ewan Birney,Robert V. Bruggner,Javier Costas,Monique R. Coy,Jonathan Crabtree,Matt Crawford,Becky deBruyn,David DeCaprio,Karin Eiglmeier,Eric Eisenstadt,Hamza El-Dorry,William M. Gelbart,Suely Lopes Gomes,Martin Hammond,Linda Hannick,James R. Hogan,Michael H. Holmes,David M. Jaffe,J. Spencer Johnston,Ryan C. Kennedy,Hean Koo,Saul A. Kravitz,Evgenia V. Kriventseva,David Kulp,Kurt LaButti,Eduardo Lee,Song Li,Diane D. Lovin,Chunhong Mao,Evan Mauceli,Carlos Frederico Martins Menck,Jason R. Miller,Philip Montgomery,Akio Mori,Ana L. T. O. Nascimento,Horacio Naveira,Chad Nusbaum,Sinéad B. O'Leary,Joshua Orvis,Mihaela Pertea,Hadi Quesneville,Kyanne R. Reidenbach,Yu-Hui Rogers,Charles Roth,Jennifer R. Schneider,Michael C. Schatz,Martin Shumway,Mario Stanke,Eric O. Stinson,Jose M. C. Tubio,Janice P. Vanzee,Sergio Verjovski-Almeida,Doreen Werner,Owen White,Stefan Wyder,Qiandong Zeng,Qi Zhao,Yongmei Zhao,Catherine A. Hill,Alexander S. Raikhel,Marcelo B. Soares,Dennis L. Knudson,Norman H. Lee,James E. Galagan,Steven L. Salzberg,Ian T. Paulsen,George Dimopoulos,Frank H. Collins,Bruce W. Birren,Claire M. Fraser-Liggett,David W. Severson +94 more
TL;DR: A draft sequence of the genome of Aedes aegypti, the primary vector for yellow fever and dengue fever, which at approximately 1376 million base pairs is about 5 times the size of the genomes of the malaria vector Anopheles gambiae was presented in this paper.
Journal ArticleDOI
Evaluation and Management of Children Younger Than Two Years Old With Apparently Minor Head Trauma: Proposed Guidelines
Sara A. Schutzman,Patrick D. Barnes,Anne-Christine Duhaime,David S. Greenes,Charles J. Homer,David M. Jaffe,Roger J. Lewis,Thomas G. Luerssen,Jeff E. Schunk +8 more
TL;DR: A guideline for the evaluation of children <2 years old with minor HT is developed that categorizes children into 4 subgroups, based on risk of ICI and the effect on clinical outcomes and resource utilization should be evaluated.
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Diagnostic Testing for Acute Head Injury in Children: When Are Head Computed Tomography and Skull Radiographs Indicated?
Kimberly S. Quayle,David M. Jaffe,Nathan Kuppermann,Bruce A. Kaufman,Benjamin C. P. Lee,Tae Sung Park,William H. McAlister +6 more
TL;DR: Intracranial injury may occur with few or subtle signs and symptoms, especially in infants younger than 1 year, and the relative risk for intracrania injury is increased almost fourfold in the presence of a skull fracture, although the absence of a skulls fracture does not rule out intrac Cranial injury.