D
David Meder
Researcher at Copenhagen University Hospital
Publications - 19
Citations - 462
David Meder is an academic researcher from Copenhagen University Hospital. The author has contributed to research in topics: Parkinson's disease & Ergodicity. The author has an hindex of 7, co-authored 15 publications receiving 272 citations.
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Journal ArticleDOI
Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseases
Matthew J. Betts,Matthew J. Betts,Evgeniya Kirilina,Evgeniya Kirilina,Maria Concepcion Garcia Otaduy,Dimo Ivanov,Julio Acosta-Cabronero,Martina F. Callaghan,Christian Lambert,Arturo Cardenas-Blanco,Arturo Cardenas-Blanco,Kerrin Pine,Kerrin Pine,Luca Passamonti,Clare Loane,Max C. Keuken,Max C. Keuken,Paula Trujillo,Falk Lüsebrink,Hendrik Mattern,Kathy Y. Liu,Nikos Priovoulos,Klaus Fliessbach,Klaus Fliessbach,Martin J. Dahl,Anne Maaß,Christopher Fugl Madelung,David Meder,Alexander J. Ehrenberg,Alexander J. Ehrenberg,Oliver Speck,Nikolaus Weiskopf,Nikolaus Weiskopf,Raymond J. Dolan,Raymond J. Dolan,Ben Inglis,Duygu Tosun,Markus Morawski,Fabio A. Zucca,Hartwig R. Siebner,Mara Mather,Kamil Uludag,Kamil Uludag,Helmut Heinsen,Helmut Heinsen,Benedikt A. Poser,Robert Howard,Luigi Zecca,Luigi Zecca,James B. Rowe,Lea T. Grinberg,Lea T. Grinberg,Heidi I.L. Jacobs,Heidi I.L. Jacobs,Emrah Düzel,Emrah Düzel,Emrah Düzel,Dorothea Hämmerer,Dorothea Hämmerer,Dorothea Hämmerer +59 more
TL;DR: How in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases is described and a strategy for achieving reliable and biologically validated imaging approaches is outlined.
Journal ArticleDOI
The role of dopamine in the brain - lessons learned from Parkinson's disease.
TL;DR: The role of dopamine in motor control and cognition in humans with Parkinson's disease has been investigated in functional magnetic resonance imaging (fMRI) in patients as mentioned in this paper, showing that the amount of neurodegeneration in the task-relevant nuclei and pharmacological dopamine replacement can move performance either away or towards the task specific optimum.
Journal ArticleDOI
Sensorimotor subthalamic stimulation restores risk-reward trade-off in Parkinson's disease.
Friederike Irmen,Friederike Irmen,Andreas Horn,David Meder,Wolf-Julian Neumann,Philip Plettig,Gerd-Helge Schneider,Hartwig R. Siebner,Andrea A. Kühn +8 more
TL;DR: STN‐DBS effectively treats motor symptoms of advanced PD and the volume of tissue activated and weighted stimulation of STN motor versus nonmotor territories are yet to be linked to differential DBS effects on cognition.
Journal ArticleDOI
Tuning the Brake While Raising the Stake: Network Dynamics during Sequential Decision-Making
David Meder,Brian N. Haagensen,Oliver J. Hulme,Tobias Morville,Sofie V. Gelskov,Damian M. Herz,Beata Diomsina,Mark Schram Christensen,Kristoffer Hougaard Madsen,Hartwig R. Siebner +9 more
TL;DR: The results implicate a key role of dorsal anterior cingulate cortex, pre-SMA, inferior frontal gyrus, and STN in computing the trade-off between escalating reward and risk in sequential decision-making.
Journal ArticleDOI
Brain Motor Network Changes in Parkinson's Disease: Evidence from Meta-Analytic Modeling
Damian M. Herz,David Meder,Julia A. Camilleri,Simon B. Eickhoff,Hartwig R. Siebner,Hartwig R. Siebner +5 more
TL;DR: In this article, a quantitative meta-analysis of functional neuroimaging studies testing limb movements in Parkinson's disease comprising data from 39 studies, of which 15 studies (285 of 571 individual patients) were published after the previous meta analysis, and they also conducted meta-analytic connectivity modeling to elucidate the connectivity profiles of areas showing abnormal activation.