Arturo Cardenas-Blanco

TL;DR: How in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases is described and a strategy for achieving reliable and biologically validated imaging approaches is outlined.

TL;DR: It is shown that older adults with reduced structural LC integrity show poorer subsequent memory, and salient stimuli led to greater pupil diameters, consistent with increased LC activation during the encoding of such events.

TL;DR: Using 7 Tesla time-of-flight angiography, Perosa et al. examine the impact of differences in elderly adults with and without cerebral small vessel disease, finding a mixed hippocampal supply provides a hippocampal vascular reserve that protects against cognitive impairment.

TL;DR: This study aimed to assess how interindividual differences in locus coeruleus (LC) magnetic resonance imaging (MRI) contrast relate to cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD).

TL;DR: Analyzing the relationship between subregional MTL activity, memory performance, and levels of total and phosphorylated tau as well as Aβ42/40 ratio in CSF shows that measures of tau pathology are associated with increased hippocampal activity and reduced mnemonic discrimination of similar objects but not scenes, suggesting that object mnemon discrimination tasks could be promising markers for tau-related cognitive decline.