Martin J. Dahl

TL;DR: How in vivo locus coeruleus imaging can be used as a biomarker for noradrenergic dysfunction in neurodegenerative diseases is described and a strategy for achieving reliable and biologically validated imaging approaches is outlined.

TL;DR: It is reported that ‘youth-like’ rostral locus coeruleus integrity is associated with better memory performance in the elderly and link non-invasive, in vivo indices of LC integrity to memory in ageing.

TL;DR: Overall, the results suggest that the responsiveness of the NE system supports attention across the lifespan, and link animal and human studies on the neural underpinning of attention in aging and underscore the importance of the noradrenergic system in late-life cognition.

TL;DR: In this article, the authors examined the relationship between cortical thickness and a measure reflecting LC integrity in 229 older and 67 younger adults using a magnetic resonance imaging sequence which yields high signal intensity in the locus coeruleus (LC) and assessed the contrast between signal intensity of the LC and that of neighboring pontine reference tissue.

TL;DR: It is shown that PTSD symptoms in heavily traumatized refugees are related to deficits in the effective control of memory retrieval, and the inability to suppress unwanted memories through modulation of gamma activity is related to PTSD symptom severity.