D
David W. Hogg
Researcher at University of Toronto
Publications - 121
Citations - 29207
David W. Hogg is an academic researcher from University of Toronto. The author has contributed to research in topics: Melanoma & Germline mutation. The author has an hindex of 34, co-authored 113 publications receiving 25771 citations. Previous affiliations of David W. Hogg include University Health Network & Princess Margaret Cancer Centre.
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Journal ArticleDOI
Results of a Phase III, Randomized, Placebo-Controlled Study of Sorafenib in Combination With Carboplatin and Paclitaxel As Second-Line Treatment in Patients With Unresectable Stage III or Stage IV Melanoma
Axel Hauschild,Sanjiv S. Agarwala,Uwe Trefzer,David W. Hogg,Caroline Robert,Peter Hersey,Alexander M.M. Eggermont,Stephan Grabbe,Rene Gonzalez,Jens Gille,Christian Peschel,Dirk Schadendorf,Claus Garbe,Steven J. O'Day,Adil Daud,J. Michael White,Chenghua Xia,Kiran Patel,John M. Kirkwood,Ulrich Keilholz +19 more
TL;DR: The addition of sorafenib to CP did not improve any of the end points over placebo plus CP and cannot be recommended in the second-line setting for patients with advanced melanoma.
Journal ArticleDOI
High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL
Alisa M. Goldstein,May Chan,Mark Harland,Elizabeth M. Gillanders,Nicholas K. Hayward,Marie-Françoise Avril,Esther Azizi,Giovanna Bianchi-Scarrà,D. Timothy Bishop,Brigitte Bressac-de Paillerets,William Bruno,Donato Calista,Lisa A. Cannon Albright,Florence Demenais,David E. Elder,Paola Ghiorzo,Nelleke A. Gruis,Johan Hansson,David W. Hogg,Elizabeth A. Holland,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Sancy A. Leachman,Rona M. MacKie,Veronica Magnusson,Graham J. Mann,Kristin B. Niendorf,Julia A. Newton Bishop,Jane M. Palmer,Susana Puig,Joan Anton Puig-Butille,Femke A. de Snoo,Mitchell S. Stark,Hensin Tsao,Margaret A. Tucker,Linda Whitaker,Emanuel Yakobson,Joseph Malvehy,Celia Badenas,R. Cervera,Francisco Cuellar,Francisco Cuellar,Rosa M. Martí,Joan Brunet-Vidal,Guang Yang,Nicholas G. Martin,David C. Whiteman,Adèle C. Green,Joanne F. Aitken,Paola Minghetti,Michela Mantelli,Lorenza Pastorino,Sabina Nasti,Sara Gargiulo,Sara Gliori,Sushila Mistry,Juliette Randerson-Moor,Wilma Bergman,Jeanet A.C. ter Huurne,Clasine van der Drift,Leny van Mourik,Coby Out-Luiting,Frans A. van Nieuwpoort,Valérie Chaudru,Agnès Chompret,Caroline Kanengiesser,J. L. Michel,Florent Grange,B. Sassolas,Jean -Marc Limacher,D. Couillet,F. Truchetet,J. P. Cesarini,F. Boitier,Jacqueline Chevrant-Breton,Christine Lasset,Michel Longy,Pascal Joly,Nicole Basset-Seguin,T. Lesimple,Catherine Dugast,Arupa Ganguly,Michael Ming,Patricia Van Belle,Anton Platz,Suzanne Egyhazi,Rainer Tuominen,Diana Linden,Helen Schmid,Alon Scope,Felix Pavlotsky,Eitan Friedman,Mark J. Eliason,Christian Ingvar,Åke Borg,Johan Westerdahl,Anna Måsbäck,Håkan Olsson +99 more
TL;DR: This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available and there was little evidence for an association between CDKN2A mutations and NST, but there was a marginally significant association between NST and ARF.
Journal ArticleDOI
Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma‐prone families from three continents
Alisa M. Goldstein,May Chan,Mark Harland,Nicholas K. Hayward,Florence Demenais,D. Timothy Bishop,Esther Azizi,Wilma Bergman,Giovanna Bianchi-Scarrà,William Bruno,Donato Calista,Lisa A. Cannon Albright,Valérie Chaudru,Agnès Chompret,Francisco Cuellar,David E. Elder,Paola Ghiorzo,Elizabeth M. Gillanders,Nelleke A. Gruis,Johan Hansson,David W. Hogg,Elizabeth A. Holland,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Sancy A. Leachman,Rona M. MacKie,Veronica Magnusson,Graham J. Mann,Julia A. Newton Bishop,Jane M. Palmer,Susana Puig,Joan Anton Puig-Butille,Mitchell S. Stark,Hensin Tsao,Margaret A. Tucker,Linda Whitaker,Emanuel Yakobson +38 more
TL;DR: The variation in CDKN2A mutations for the four features across continents is consistent with the lower melanoma incidence rates in Europe and higher rates of sporadic melanoma in Australia, which reflects the divergent spectrum of mutations in families from Australia versus those from North America and Europe.
Journal ArticleDOI
The Milky Way has no thick disk
TL;DR: In this paper, the authors derived the surface-mass contributions of stellar populations with scale height h_z, and found no hint of a thin-thick disk bi-modality in this mass-weighted scale-height distribution.
Journal ArticleDOI
Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma
Ling Liu,David J. Dilworth,Luzhang Gao,Jose Monzon,Ann Summers,Norman J. Lassam,David W. Hogg +6 more
TL;DR: It is shown here that a subset of these kindreds possess a G→T transversion at base –34 of CDKN2A, designated G–34T, which gives rise to a novel AUG translation initiation codon that decreases translation from the wild-type AUG.