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Alisa M. Goldstein
Researcher at National Institutes of Health
Publications - 24
Citations - 3070
Alisa M. Goldstein is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CDKN2A & Genome-wide association study. The author has an hindex of 16, co-authored 24 publications receiving 2761 citations. Previous affiliations of Alisa M. Goldstein include United States Department of Health and Human Services.
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Journal ArticleDOI
Genome-wide association study identifies three loci associated with melanoma risk.
D. Timothy Bishop,Florence Demenais,Mark M. Iles,Mark Harland,John C. Taylor,Eve Corda,Eve Corda,Juliette Randerson-Moor,Joanne F. Aitken,Marie-Françoise Avril,Esther Azizi,Bert Bakker,Giovanna Bianchi-Scarrà,Brigitte Bressac-de Paillerets,Donato Calista,Lisa A. Cannon-Albright,Thomas Chin-A-Woeng,Tadeusz Dębniak,Gilli Galore-Haskel,Paola Ghiorzo,Ivo Gut,Johan Hansson,Marko Hočevar,Veronica Höiom,John L. Hopper,Christian Ingvar,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Jan Lubinski,Rona M. MacKie,Josep Malvehy,Graham J. Mann,Nicholas G. Martin,Grant W. Montgomery,Frans A. van Nieuwpoort,Srdjan Novaković,Håkan Olsson,Susana Puig,Marjan M. Weiss,Wilbert van Workum,Diana Zelenika,Kevin M. Brown,Alisa M. Goldstein,Elizabeth M. Gillanders,Anne Boland,Pilar Galan,David E. Elder,Nelleke A. Gruis,Nicholas K. Hayward,G. Mark Lathrop,G. Mark Lathrop,Jennifer H. Barrett,Julia A. Newton Bishop +54 more
TL;DR: Despite wide variation in allele frequency, these genetic variants show notable homogeneity of effect across populations of European ancestry living at different latitudes and show independent association to disease risk.
Journal ArticleDOI
High-risk Melanoma Susceptibility Genes and Pancreatic Cancer, Neural System Tumors, and Uveal Melanoma across GenoMEL
Alisa M. Goldstein,May Chan,Mark Harland,Elizabeth M. Gillanders,Nicholas K. Hayward,Marie-Françoise Avril,Esther Azizi,Giovanna Bianchi-Scarrà,D. Timothy Bishop,Brigitte Bressac-de Paillerets,William Bruno,Donato Calista,Lisa A. Cannon Albright,Florence Demenais,David E. Elder,Paola Ghiorzo,Nelleke A. Gruis,Johan Hansson,David W. Hogg,Elizabeth A. Holland,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Sancy A. Leachman,Rona M. MacKie,Veronica Magnusson,Graham J. Mann,Kristin B. Niendorf,Julia A. Newton Bishop,Jane M. Palmer,Susana Puig,Joan Anton Puig-Butille,Femke A. de Snoo,Mitchell S. Stark,Hensin Tsao,Margaret A. Tucker,Linda Whitaker,Emanuel Yakobson,Joseph Malvehy,Celia Badenas,R. Cervera,Francisco Cuellar,Francisco Cuellar,Rosa M. Martí,Joan Brunet-Vidal,Guang Yang,Nicholas G. Martin,David C. Whiteman,Adèle C. Green,Joanne F. Aitken,Paola Minghetti,Michela Mantelli,Lorenza Pastorino,Sabina Nasti,Sara Gargiulo,Sara Gliori,Sushila Mistry,Juliette Randerson-Moor,Wilma Bergman,Jeanet A.C. ter Huurne,Clasine van der Drift,Leny van Mourik,Coby Out-Luiting,Frans A. van Nieuwpoort,Valérie Chaudru,Agnès Chompret,Caroline Kanengiesser,J. L. Michel,Florent Grange,B. Sassolas,Jean -Marc Limacher,D. Couillet,F. Truchetet,J. P. Cesarini,F. Boitier,Jacqueline Chevrant-Breton,Christine Lasset,Michel Longy,Pascal Joly,Nicole Basset-Seguin,T. Lesimple,Catherine Dugast,Arupa Ganguly,Michael Ming,Patricia Van Belle,Anton Platz,Suzanne Egyhazi,Rainer Tuominen,Diana Linden,Helen Schmid,Alon Scope,Felix Pavlotsky,Eitan Friedman,Mark J. Eliason,Christian Ingvar,Åke Borg,Johan Westerdahl,Anna Måsbäck,Håkan Olsson +99 more
TL;DR: This GenoMEL study provides the most extensive characterization of mutations in high-risk melanoma susceptibility genes in families with three or more melanoma patients yet available and there was little evidence for an association between CDKN2A mutations and NST, but there was a marginally significant association between NST and ARF.
Journal ArticleDOI
Features associated with germline CDKN2A mutations: a GenoMEL study of melanoma‐prone families from three continents
Alisa M. Goldstein,May Chan,Mark Harland,Nicholas K. Hayward,Florence Demenais,D. Timothy Bishop,Esther Azizi,Wilma Bergman,Giovanna Bianchi-Scarrà,William Bruno,Donato Calista,Lisa A. Cannon Albright,Valérie Chaudru,Agnès Chompret,Francisco Cuellar,David E. Elder,Paola Ghiorzo,Elizabeth M. Gillanders,Nelleke A. Gruis,Johan Hansson,David W. Hogg,Elizabeth A. Holland,Peter A. Kanetsky,Richard F. Kefford,Maria Teresa Landi,Julie Lang,Sancy A. Leachman,Rona M. MacKie,Veronica Magnusson,Graham J. Mann,Julia A. Newton Bishop,Jane M. Palmer,Susana Puig,Joan Anton Puig-Butille,Mitchell S. Stark,Hensin Tsao,Margaret A. Tucker,Linda Whitaker,Emanuel Yakobson +38 more
TL;DR: The variation in CDKN2A mutations for the four features across continents is consistent with the lower melanoma incidence rates in Europe and higher rates of sporadic melanoma in Australia, which reflects the divergent spectrum of mutations in families from Australia versus those from North America and Europe.
Journal ArticleDOI
Rare missense variants in POT1 predispose to familial cutaneous malignant melanoma.
Jianxin Shi,Xiaohong R. Yang,Bari J. Ballew,Melissa Rotunno,Donato Calista,Maria Concetta Fargnoli,Paola Ghiorzo,Brigitte Bressac-de Paillerets,Eduardo Nagore,Marie-Françoise Avril,Neil E. Caporaso,Mary L. McMaster,Michael Cullen,Michael Cullen,Zhaoming Wang,Zhaoming Wang,Xijun Zhang,Xijun Zhang,William Bruno,Lorenza Pastorino,Paola Queirolo,Jose Banuls-Roca,Zaida García-Casado,Amaury Vaysse,Amaury Vaysse,Hamida Mohamdi,Hamida Mohamdi,Yasser Riazalhosseini,Mario Foglio,Fanélie Jouenne,Xing Hua,Paula L. Hyland,Jinhu Yin,Haritha Vallabhaneni,Weihang Chai,Paola Minghetti,Cristina Pellegrini,Sarangan Ravichandran,Alexander M.M. Eggermont,Alexander M.M. Eggermont,Mark Lathrop,Mark Lathrop,Ketty Peris,Giovanna Bianchi Scarrà,Giorgio Landi,Sharon A. Savage,Joshua N. Sampson,Ji He,Ji He,Meredith Yeager,Meredith Yeager,Lynn R. Goldin,Florence Demenais,Florence Demenais,Stephen J. Chanock,Margaret A. Tucker,Alisa M. Goldstein,Yie Liu,Maria Teresa Landi +58 more
TL;DR: The findings suggest that POT1 is a major susceptibility gene for familial melanoma in several populations, and that this variant perturbs telomere maintenance.
Journal ArticleDOI
Genome-wide association study identifies three new melanoma susceptibility loci
Jennifer H. Barrett,Mark M. Iles,Mark Harland,John C. Taylor,Joanne F. Aitken,Per Arne Andresen,Lars A. Akslen,Bruce K. Armstrong,Marie-Françoise Avril,Esther Azizi,Bert Bakker,Wilma Bergman,Giovanna Bianchi-Scarrà,Brigitte Bressac-de Paillerets,Brigitte Bressac-de Paillerets,Donato Calista,Lisa A. Cannon-Albright,Eve Corda,Anne E. Cust,Tadeusz Dȩbniak,David L. Duffy,Alison M. Dunning,Douglas F. Easton,Eitan Friedman,Pilar Galan,Paola Ghiorzo,Graham G. Giles,Graham G. Giles,Johan Hansson,Marko Hočevar,Veronica Höiom,John L. Hopper,Christian Ingvar,Bart Janssen,Mark A. Jenkins,Göran Jönsson,Richard F. Kefford,Giorgio Landi,Maria Teresa Landi,Julie Lang,Jan Lubinski,Rona M. MacKie,Josep Malvehy,Nicholas G. Martin,Anders Molven,Grant W. Montgomery,Frans A. van Nieuwpoort,Srdjan Novaković,Håkan Olsson,Lorenza Pastorino,Susana Puig,Joan Anton Puig-Butille,Juliette Randerson-Moor,Helen Snowden,Rainer Tuominen,Patricia Van Belle,Nienke van der Stoep,David C. Whiteman,Diana Zelenika,Jiali Han,Shenying Fang,Jeffrey E. Lee,Qingyi Wei,G. Mark Lathrop,Elizabeth M. Gillanders,Kevin M. Brown,Alisa M. Goldstein,Peter A. Kanetsky,Graham J. Mann,Stuart MacGregor,David E. Elder,Christopher I. Amos,Nicholas K. Hayward,Nelleke A. Gruis,Florence Demenais,Julia A. Newton Bishop,D. Timothy Bishop +76 more
TL;DR: Seven new regions with at least one SNP with P < 10−5 and further local imputed or genotyped support were selected for replication using two other genome-wide studies and showed no association with nevus or pigmentation phenotypes in a large British case-control series.