D
Divya Sain
Researcher at University of California, Riverside
Publications - 6
Citations - 1751
Divya Sain is an academic researcher from University of California, Riverside. The author has contributed to research in topics: Comparative genomics & Genome. The author has an hindex of 5, co-authored 6 publications receiving 1504 citations.
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Journal ArticleDOI
Comparative genomics reveals mobile pathogenicity chromosomes in Fusarium
Li-Jun Ma,H. Charlotte van der Does,Katherine A. Borkovich,Jeffrey J. Coleman,Marie Josée Daboussi,Antonio Di Pietro,Marie Dufresne,Michael Freitag,Manfred Grabherr,Bernard Henrissat,Petra M. Houterman,Seogchan Kang,Won-Bo Shim,Charles P. Woloshuk,Xiaohui Xie,Jin-Rong Xu,John F. Antoniw,Scott E. Baker,B. H. Bluhm,Andrew Breakspear,Daren W. Brown,Robert A. E. Butchko,Sinéad B. Chapman,Richard M.R. Coulson,Pedro M. Coutinho,Etienne Danchin,Etienne Danchin,Andrew C. Diener,Liane R. Gale,Donald M. Gardiner,Stephen A. Goff,Kim E. Hammond-Kosack,Karen Hilburn,Aurélie Hua-Van,Wilfried Jonkers,Kemal Kazan,Chinnappa D. Kodira,Michael Koehrsen,Lokesh Kumar,Yong-Hwan Lee,Liande Li,Liande Li,John M. Manners,Diego Miranda-Saavedra,Mala Mukherjee,Gyungsoon Park,Jongsun Park,Sook Young Park,Sook Young Park,Robert H. Proctor,Aviv Regev,M. Carmen Ruiz-Roldán,Divya Sain,Sharadha Sakthikumar,Sean M. Sykes,David C. Schwartz,B. Gillian Turgeon,Ilan Wapinski,Olen C. Yoder,Sarah Young,Qiandong Zeng,Shiguo Zhou,James E. Galagan,Christina A. Cuomo,H. Corby Kistler,Martijn Rep +65 more
TL;DR: Comparison of genomes of three phenotypically diverse Fusarium species revealed lineage-specific genomic regions in F. oxysporum that include four entire chromosomes and account for more than one-quarter of the genome, putting the evolution of fungal pathogenicity into a new perspective.
Journal ArticleDOI
Shared Signatures of Parasitism and Phylogenomics Unite Cryptomycota and Microsporidia
Timothy Y. James,Adrian Pelin,Linda Bonen,Steven R. Ahrendt,Divya Sain,Nicolas Corradi,Jason E. Stajich +6 more
TL;DR: The first Cryptomycotan genome is sequence and it is proposed that Cryptomycota and microsporidia share a common endoparasitic ancestor, with the clade unified by a chitinous cell wall used to develop turgor pressure in the infection process.
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Deciphering the uniqueness of Mucoromycotina cell walls by combining biochemical and phylogenomic approaches.
TL;DR: The uniqueness of the cell wall structure of the Mucoromycotina Rhizopus oryzae and Phycomyces blakesleeanus compared with the better characterized cell wall of the ascomycete Neurospora crassa is revealed and the presence of abundant fucose-based polysaccharides similar to algal fucoidans is uncovered.
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Comparative genomic analysis of the 'pseudofungus' Hyphochytrium catenoides.
Guy Leonard,Aurélie Labarre,David S. Milner,Adam Monier,Darren M. Soanes,Jeremy G. Wideman,Finlay Maguire,Sam M. Stevens,Divya Sain,Xavier Grau-Bové,Arnau Sebé-Pedrós,Jason E. Stajich,Konrad Paszkiewicz,Matthew Brown,Neil Hall,Bill Wickstead,Thomas A. Richards +16 more
TL;DR: Comparative genomics identified differences in the repertoire of genes associated with filamentous growth between the Fungi and the Pseudofungi, including differences in vesicle trafficking systems, cell-wall synthesis pathways and motor protein repertoire, demonstrating that unique cellular systems underpinned the convergent evolution of filamentous osmotrophic growth in these two eukaryotic groups.
Journal ArticleDOI
Detection of structural variation using target captured next-generation sequencing data for genetic diagnostic testing.
Wenbo Mu,Bing Li,Sitao Wu,Jefferey Chen,Divya Sain,Dong Xu,Mary Helen Black,Rachid Karam,Katrina Gillespie,Kelly D. Farwell Hagman,Lucia Guidugli,Melissa Pronold,Aaron Elliott,Hsiao-Mei Lu +13 more
TL;DR: The SVs presented here can be used as a valuable resource for clinical research and diagnostics and illustrate NGS as a powerful tool for SV detection.