D
Dorothea Fiedler
Researcher at Humboldt University of Berlin
Publications - 98
Citations - 5794
Dorothea Fiedler is an academic researcher from Humboldt University of Berlin. The author has contributed to research in topics: Inositol & Kinase. The author has an hindex of 33, co-authored 85 publications receiving 5000 citations. Previous affiliations of Dorothea Fiedler include University of California, San Francisco & Howard Hughes Medical Institute.
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Journal ArticleDOI
Selective molecular recognition, C-H bond activation, and catalysis in nanoscale reaction vessels
TL;DR: In this paper, a chiral self-assembled M4L6 supramolecular tetrahedron can encapsulate a variety of cationic guests with varying degrees of stereoselectivity.
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Rewiring of genetic networks in response to DNA damage
Sourav Bandyopadhyay,Monika Mehta,Dwight Kuo,Min-Kyung Sung,Ryan Chuang,Eric J. Jaehnig,Bernd Bodenmiller,Katherine Licon,Wilbert Copeland,Michael Shales,Dorothea Fiedler,Dorothea Fiedler,Janusz Dutkowski,Aude Guénolé,Haico van Attikum,Kevan M. Shokat,Kevan M. Shokat,Richard D. Kolodner,Won-Ki Huh,Ruedi Aebersold,Michael-Christopher Keogh,Nevan J. Krogan,Trey Ideker +22 more
TL;DR: Using an approach called differential epistasis mapping, widespread changes in genetic interaction are discovered among yeast kinases, phosphatases, and transcription factors as the cell responds to DNA damage, uncovering many gene functions that go undetected in static conditions.
Journal ArticleDOI
Functional Organization of the S. cerevisiae Phosphorylation Network
Dorothea Fiedler,Dorothea Fiedler,Hannes Braberg,Monika Mehta,Gal Chechik,Gerard Cagney,Gerard Cagney,Paromita Mukherjee,Andrea C. Silva,Michael Shales,Sean R. Collins,Sean R. Collins,Sake van Wageningen,Patrick Kemmeren,Frank C. P. Holstege,Jonathan S. Weissman,Jonathan S. Weissman,Michael-Christopher Keogh,Daphne Koller,Kevan M. Shokat,Kevan M. Shokat,Nevan J. Krogan +21 more
TL;DR: An epistatic miniarray profile comprised of 100,000 pairwise, quantitative genetic interactions, including virtually all protein and small-molecule kinases and phosphatases as well as key cellular regulators is generated, finding an enrichment of positive genetic interactions between kinases, phosphatase, and their substrates.
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Inhibitor Hijacking of Akt Activation
Tatsuya Okuzumi,Dorothea Fiedler,Chao Zhang,Daniel C. Gray,Brian Aizenstein,Randy Hoffman,Kevan M. Shokat,Kevan M. Shokat +7 more
TL;DR: It is concluded that ATP-competitive Akt inhibitors impart regulatory phosphorylation of their target kinase Akt providing new insights into both natural regulation of Akt activation andAkt inhibitors entering the clinic.
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Supramolecular catalysis of a unimolecular transformation: Aza-cope rearrangement within a self-assembled host
TL;DR: The utilization of a supramolecular metal–ligand assembly that is capable of catalyzing a unimolecular rearrangement is reported, and by inclusion into a sizeand shape-constrained reaction space these rearrangements are accelerated by up to three orders of magnitude compared to their background rates.