G
Giles Edwards
Researcher at Stobhill Hospital
Publications - 82
Citations - 4437
Giles Edwards is an academic researcher from Stobhill Hospital. The author has contributed to research in topics: Methicillin-resistant Staphylococcus aureus & Legionella pneumophila. The author has an hindex of 30, co-authored 81 publications receiving 3932 citations. Previous affiliations of Giles Edwards include Public Health England & NHS Greater Glasgow and Clyde.
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Journal ArticleDOI
Meticillin-resistant Staphylococcus aureus with a novel mecA homologue in human and bovine populations in the UK and Denmark: a descriptive study.
Laura García-Álvarez,Matthew T. G. Holden,Heather Lindsay,Cerian R. Webb,Derek F. J. Brown,Martin D. Curran,Enid Walpole,Karen Brooks,Derek Pickard,Christopher Teale,Julian Parkhill,Stephen D. Bentley,Giles Edwards,E Kirsty Girvan,Angela M. Kearns,Bruno Pichon,Robert Hill,Anders Rhod Larsen,Robert Skov,Sharon J. Peacock,Duncan J. Maskell,Mark A. Holmes +21 more
TL;DR: The discovery of a strain of S aureus isolated from bulk milk that was phenotypically resistant to meticillin but tested negative for the mecA gene is reported and new diagnostic guidelines for the detection of MRSA should consider the inclusion of tests for mecALGA251.
Journal ArticleDOI
A genomic portrait of the emergence, evolution, and global spread of a methicillin-resistant Staphylococcus aureus pandemic
Matthew T. G. Holden,Li Yang Hsu,Li Yang Hsu,Kevin Kurt,Lucy A. Weinert,Lucy A. Weinert,Alison E. Mather,Simon R. Harris,Birgit Strommenger,Franziska Layer,Wolfgang Witte,Hermínia de Lencastre,Hermínia de Lencastre,Robert Skov,Henrik Westh,Henrik Westh,Helena Žemličková,Geoffrey W. Coombs,Angela M. Kearns,Robert Hill,Jonathan D. Edgeworth,Ian M. Gould,Vanya Gant,Jonathan Cooke,Giles Edwards,Paul R. McAdam,Kate Templeton,Angela McCann,Zhemin Zhou,Santiago Castillo-Ramírez,Edward J. Feil,Lyndsey O. Hudson,Mark C. Enright,Francois Balloux,Francois Balloux,David M. Aanensen,Brian G. Spratt,J. Ross Fitzgerald,Julian Parkhill,Mark Achtman,Stephen D. Bentley,Ulrich Nübel +41 more
TL;DR: The genetic changes associated with adaptation to the hospital environment and with increasing drug resistance over time are document, and how MRSA evolution likely has been influenced by country-specific drug use regimens are documented.
Journal ArticleDOI
Rapid detection, differentiation and typing of methicillin-resistant Staphylococcus aureus harbouring either mecA or the new mecA homologue mecALGA251
Marc Stegger,Paal Skytt Andersen,Angela M. Kearns,Bruno Pichon,Mark A. Holmes,Giles Edwards,Frédéric Laurent,Christopher Teale,Robert Skov,Anders Rhod Larsen +9 more
TL;DR: Over a 2-month period, 12 new MRSA cases caused by isolates carrying mecA(LGA251) were identified, emphasizing the clinical importance of testing for these new MR SA isolates.
Journal ArticleDOI
Re-emergence of early pandemic Staphylococcus aureus as a community-acquired meticillin-resistant clone
D. Ashley Robinson,Angela M. Kearns,A. Holmes,Donald Morrison,Hajo Grundmann,Giles Edwards,Frances G. O'Brien,Fred C. Tenover,Linda K. McDougal,Alastair B. Monk,Mark C. Enright +10 more
TL;DR: Multilocus sequence analysis suggested that descendants of phage type 80/81 have acquired meticillin resistance, are re-emerging as a community-acquired meticillin-resistant S aureus (MRSA) clone, and represent a sister lineage to pandemic hospital- acquired MRSA.
Journal ArticleDOI
Escherichia coli and Staphylococcus aureus: bad news and good news from the European Antimicrobial Resistance Surveillance Network (EARS-Net, formerly EARSS), 2002 to 2009
Carlo Gagliotti,Arta Balode,F. Baquero,John E. Degener,Hajo Grundmann,D Gür,Vincent Jarlier,Gunnar Kahlmeter,J. Monen,Dominique L Monnet,Gian Maria Rossolini,Carl Suetens,Klaus Weist,Ole Eske Heuer,Petra Apfalter,G. El Belazi,G. Fluch,C. Hain,H. Hrabcik,Walter Koller,S. Metz-Gercek,R. Muchl,R. Strauss,Boudewijn Catry,M. Fauville Dufaux,Herman Goossens,M. Goossens,L. Meulenbergs,S. Vaerenberg,T. Kantardjiev,B. Markova,J. Stoyanova Marteva-Proevska,P. Maikanti Charalambous,D Pieridou Bagatzouni,V. Jakubu,Pavla Urbášková,Helena Zemlickova,M. Galle,Anette M. Hammerum,S. Olsen,K. Schultz Nielsen,Robert Skov,T. Aro,I. Dontsenko,Marina Ivanova,K. Kermes,A. Lemetsar,Antti J. Hakanen,Outi Lyytikäinen,T. Möttönen,Bruno Coignard,H de Valk,S. Maugat,D. Trystram,D. Altmann,A. Gilsdorf,I. Noll,A. Tille,Wolfgang Witte,Vivi Miriagou,M. Polemis,Athanassios Tsakris,Alkiviadis Vatopoulos,K. Böröcz,M. Melles,Akos Toth,Z. Vegh,Haraldur Briem,L. Helgadottir,Karl G. Kristinsson,J. Brazil,R. Cunney,M. Fitzgerald,P. Hanrahan,S. Murchan,O. Murphy,B. O'Connell,Fortunato D'Ancona,Stefania Iannazzo,Annalisa Pantosti,R. Nikiforova,A. Berzanskyte,L. Dagyte-Sileikiene,Jolanta Miciuleviciene,D. Hansen-Koenig,Monique Perrin-Weniger,Michael Borg,E. Scicluna,R. Zammit Cassar,A J de Neeling,N. Van De Sande,K. Konsmo,Gunnar Skov Simonsen,Martin Steinbakk,K. Wathne,F. Width Gran,W. Hryniewicz,M. Sitkiewicz,M. Sulik,Dorota Zabicka,Manuela Caniça,C. Costa,Vera Manageiro,I. Codita,Roxana Ioana Serban,N. Bergant,Jana Kolman,M. Mueller-Premru,J. Campos Marques,J. Oteo Iglesias,María Pérez-Vázquez,I. Alefjord,A. Linde,Barbro Olsson-Liljequist,J. Struwe,Ruth Blackburn,K. Eastick,Giles Edwards,I. Fisher,Robert Hill,Alan P. Johnson,F. Johnston,G. Mcilvenny,A. Mullings,N. Nirmal,L. Patterson,Jennie Wilson +126 more
TL;DR: The observed trend suggests an increasing burden of disease caused by E. coli and a lesser increase in S. aureus infections, which may reflect the success of infection control measures at hospital level in several European countries.