S
Stuart Creton
Researcher at Imperial College London
Publications - 21
Citations - 1285
Stuart Creton is an academic researcher from Imperial College London. The author has contributed to research in topics: 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine & Carcinogenesis. The author has an hindex of 16, co-authored 21 publications receiving 1189 citations. Previous affiliations of Stuart Creton include Wellington Management Company.
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Journal ArticleDOI
Alternative (non-animal) methods for cosmetics testing: current status and future prospects—2010
Sarah Adler,David A. Basketter,Stuart Creton,Olavi Pelkonen,Jan van Benthem,Valérie Zuang,Klaus Ejner Andersen,Alexandre Angers-Loustau,Aynur O. Aptula,Anna Bal-Price,Emilio Benfenati,Ulrike Bernauer,J.G.M. Bessems,Frédéric Y. Bois,Alan R. Boobis,Esther Brandon,Susanne Bremer,Thomas H. Broschard,Silvia Casati,Sandra Coecke,Raffaella Corvi,Mark T. D. Cronin,George P. Daston,Wolfgang Dekant,Susan P. Felter,Elise Grignard,Ursula Gundert-Remy,Tuula Heinonen,Ian Kimber,Jos C. S. Kleinjans,Hannu Komulainen,Reinhard Kreiling,Joachim Kreysa,Sofia B. Leite,George Loizou,Gavin Maxwell,Paolo Mazzatorta,Sharon Munn,Stefan Pfuhler,Pascal Phrakonkham,Aldert H. Piersma,Albrecht Poth,Pilar Prieto,Guillermo Repetto,Vera Rogiers,Greet Schoeters,Michael Schwarz,Rositsa Serafimova,Hanna Tähti,Emanuela Testai,Joost H.M. van Delft,Henk Van Loveren,Mathieu Vinken,Andrew Worth,Jose-Manuel Zaldivar +54 more
TL;DR: In this paper, Adler et al. present a survey of the authors' work in the field of bioinformatics, including the following authors:Sarah AdlerDavid BasketterStuart CretonOlavi PelkonenJan van BenthemValerie Zuang • Klaus Ejner AndersenAlexandre Angers-LoustauAynur AptulaAnna Bal-PriceEmilio Benfenati • Ulrike BernauerJos BessemsFrederic Y. BoisAlan BoobisEsther BrandonSusanne Bremer • Thomas
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A European perspective on alternatives to animal testing for environmental hazard identification and risk assessment
Stefan Scholz,Erika Sela,Ludek Blaha,Thomas Braunbeck,Malyka Galay-Burgos,Mauricio García-Franco,Joaquin Guinea,Nils Klüver,Kristin Schirmer,Kristin Schirmer,Katrin Tanneberger,Marysia Tobor-Kapłon,Hilda Witters,Scott E. Belanger,Emilio Benfenati,Stuart Creton,Mark T. D. Cronin,Rik I.L. Eggen,Rik I.L. Eggen,Michelle R. Embry,Drew R. Ekman,Anne Gourmelon,Marlies Halder,Barry Hardy,Thomas Hartung,Bruno Hubesch,Dirk Jungmann,Mark A. Lampi,Lucy E. J. Lee,Marc Léonard,Eberhard Küster,Adam Lillicrap,Till Luckenbach,Albertinka J. Murk,José María Navas,Willie J.G.M. Peijnenburg,Guillermo Repetto,Edward Salinas,Gerrit Schüürmann,Horst Spielmann,Knut Erik Tollefsen,Susanne Walter-Rohde,Graham Whale,James R. Wheeler,Matthew J. Winter +44 more
TL;DR: An overview on current regulations of chemicals and the requirements for animal tests in environmental hazard and risk assessment is provided and the potential areas for alternative approaches to animal tests using vertebrates in environmental toxicology are highlighted.
Journal ArticleDOI
Pharmaceutical toxicology: Designing studies to reduce animal use, while maximizing human translation
Kathryn Chapman,Henry Holzgrefe,Lauren E. Black,Marilyn J. Brown,Gary J. Chellman,Christine Copeman,Jessica Couch,Stuart Creton,Sean C. Gehen,Alan M. Hoberman,Lewis B. Kinter,Stephen Madden,Charles Mattis,Hugh A. Stemple,Stephen Wilson +14 more
TL;DR: The authors have identified opportunities to maximize the predictivity of this information to humans while reducing animal use in four key areas; accelerating the uptake of in vitro methods, incorporating the latest science into safety pharmacology assessments, and optimizing rodent study design in biological development.
Journal ArticleDOI
Acute toxicity testing of chemicals—Opportunities to avoid redundant testing and use alternative approaches
Stuart Creton,Ian C. Dewhurst,Lesley Earl,Sean C. Gehen,Robert Guest,Jon A. Hotchkiss,Ian Indans,Michael R. Woolhiser,Richard Billington +8 more
TL;DR: Assessment of data from acute oral and dermal toxicity testing demonstrates that acute dermal testing rarely provides value for hazard assessment purposes when an acute oral study has been conducted.
Journal ArticleDOI
Molecular and genetic toxicology of 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP).
TL;DR: Using co-culture systems where one cell line bioactivates PhIP with a second cell line as target, it was shown in human lymphoblastoid target cells that PhIP induced a dose- and time-dependent S-phase delay of the cell cycle.