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Elise D. Flynn
Researcher at Columbia University
Publications - 13
Citations - 2088
Elise D. Flynn is an academic researcher from Columbia University. The author has contributed to research in topics: Exome & Genome-wide association study. The author has an hindex of 8, co-authored 11 publications receiving 791 citations. Previous affiliations of Elise D. Flynn include National Institutes of Health.
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Journal ArticleDOI
The GTEx Consortium atlas of genetic regulatory effects across human tissues
François Aguet,Alvaro N. Barbeira,Rodrigo Bonazzola,Andrew A. Brown,SE Castel,Brian Jo,Silva Kasela,Sarah Kim-Hellmuth,Yanyu Liang,Meritxell Oliva,Elise D. Flynn,Princy Parsana,Laure Fresard,Eric R. Gamazon,Andrew R. Hamel,Yuan He,Farhad Hormozdiari,Pejman Mohammadi,Manuel Muñoz-Aguirre,YoSon Park,Ashis Saha,Ayellet V. Segrè,Benjamin J. Strober,Xiaoquan Wen,Wucher,Kristin G. Ardlie,Alexis Battle,Christopher D. Brown,Nancy J. Cox,Souvik Das,Emmanouil T. Dermitzakis,Barbara E. Engelhardt,D Garrido-Martin,Gad Getz,Roderic Guigó,Robert E. Handsaker,Paul J. Hoffman,Hae Kyung Im,Seva Kashin,Alan Kwong,Lappalainen T,Xiao Li,Daniel G. MacArthur,Stephen B. Montgomery,John M. Rouhana,Matthew Stephens,Barbara E. Stranger,Ellen Todres,Ana Viñuela,Gao Wang,Yuxin Zou,Shankara Anand,S. Gabriel,Aaron Graubert,Kane Hadley,Katherine H. Huang,Meier,Jared L. Nedzel,Duyen T. Nguyen,Brunilda Balliu,Donald F. Conrad,Daniel J. Cotter,OM deGoede,Jonah Einson,Eskin E,Tiffany Eulalio,Nicole M. Ferraro,Michael J. Gloudemans,Lei Hou,Serghei Mangul,Daniel Nachun,Andrew B. Nobel,Abhiram Rao,Ferran Reverter,Chiara Sabatti,Andrew D Skol,Nicole A. Teran,Fred A. Wright,Pedro G. Ferreira,Gen Li,Marta Melé,Esti Yeger-Lotem,Mary Barcus,Debra Bradbury,T Krubit,Jeffrey McLean,Liqun Qi,Karna Robinson,Nancy Roche,Anna M. Smith,David E. Tabor,Anita H. Undale,Jason Bridge,Lori E. Brigham,Barbara A. Foster,Bryan Gillard,Rick Hasz,Marcus Hunter,Christopher Johns,Mark H. Johnson,Ellen Karasik,Gene Kopen,William F. Leinweber,Alisa McDonald,Mike Moser,Kevin Myer,Kimberly Ramsey,Bruce A. Roe,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Jessica Wheeler,Scott D. Jewell,Daniel C. Rohrer,David A. Davis,Deborah C. Mash,Leslie H. Sobin,Laura Barker,HM Gardiner,Maghboeba Mosavel,Laura A. Siminoff,Paul Flicek,Maximilian Haeussler,Thomas Juettemann,W. J. Kent,Christopher Lee,CC Powell,Kate R. Rosenbloom,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Zerbino,Nathan S. Abell,Joshua M. Akey,Lin Chen,Kathryn Demanelis,Jennifer A. Doherty,Andrew P. Feinberg,Kasper D. Hansen,Peter Hickey,Farzana Jasmine,Lihua Jiang,Rajinder Kaul,Manolis Kellis,Muhammad G. Kibriya,Jin Billy Li,Qin Li,Shin Lin,Sandra Linder,Brandon L. Pierce,Lindsay F. Rizzardi,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Meng Wang,Phillip Branton,Latarsha J. Carithers,Ping Guan,Susan E. Koester,AR Little,Helen M. Moore,Concepcion R. Nierras,Abhi Rao,Jimmie B. Vaught,Simona Volpi +167 more
Journal ArticleDOI
Computational evaluation of exome sequence data using human and model organism phenotypes improves diagnostic efficiency
William P. Bone,Nicole L. Washington,Orion J. Buske,David R. Adams,Joie Davis,David W. Draper,Elise D. Flynn,Marta Girdea,Rena A. Godfrey,Gretchen Golas,Catherine Groden,Julius O.B. Jacobsen,Sebastian Köhler,Elizabeth M. J. Lee,Amanda E. Links,Thomas C. Markello,Christopher J. Mungall,Michele Nehrebecky,Peter N. Robinson,Murat Sincan,Ariane Soldatos,Cynthia J. Tifft,Camilo Toro,Heather Trang,Elise Valkanas,Nicole Vasilevsky,Colleen E. Wahl,Lynne A. Wolfe,Cornelius F. Boerkoel,Michael Brudno,Melissa A. Haendel,William A. Gahl,Damian Smedley +32 more
TL;DR: Structured phenotyping of patients and computational analysis are effective adjuncts for diagnosing patients with genetic disorders.
Journal ArticleDOI
Modeling RNA-Binding Protein Specificity In Vivo by Precisely Registering Protein-RNA Crosslink Sites.
Huijuan Feng,Suying Bao,Mohammad Alinoor Rahman,Sebastien M. Weyn-Vanhentenryck,Aziz Khan,Justin Wong,Ankeeta Shah,Elise D. Flynn,Adrian R. Krainer,Chaolin Zhang +9 more
TL;DR: This work has developed a computational method, named mCross, to jointly model RBP binding specificity while precisely registering the crosslinking position in motif sites, and revealed that the prototypical SR protein SRSF1 recognizes clusters of GGA half-sites in addition to its canonical GGAGGA motif.
Journal ArticleDOI
A vast resource of allelic expression data spanning human tissues
Stephane E. Castel,François Aguet,Pejman Mohammadi,Shankara Anand,Kristin G. Ardlie,Stacey Gabriel,Gad Getz,Aaron Graubert,Kane Hadley,Robert E. Handsaker,Katherine H. Huang,Seva Kashin,Xiao Li,Daniel G. MacArthur,Sam Meier,Jared L. Nedzel,Duyen T. Nguyen,Ayellet V. Segrè,Ellen Todres,Brunilda Balliu,Alvaro N. Barbeira,Alexis Battle,Rodrigo Bonazzola,Andrew Brown,Christopher D. Brown,Donald F. Conrad,Daniel J. Cotter,Nancy J. Cox,Sayantan Das,Olivia M. De Goede,Emmanouil T. Dermitzakis,Jonah Einson,Barbara E. Engelhardt,Eleazar Eskin,Tiffany Eulalio,Nicole M. Ferraro,Elise D. Flynn,Laure Fresard,Eric R. Gamazon,Diego Garrido-Martín,Michael J. Gloudemans,Roderic Guigó,Andrew R. Hame,Yuan He,Paul J. Hoffman,Farhad Hormozdiari,Lei Hou,Hae Kyung Im,Brian Jo,Silva Kasela,Manolis Kellis,Sarah Kim-Hellmuth,Alan Kwong,Tuuli Lappalainen,Xin Li,Yanyu Liang,Serghei Mangul,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Daniel Nachun,Andrew B. Nobel,Meritxell Oliva,YoSon Park,Yongjin Park,Princy Parsana,Abhiram Rao,Ferran Reverter,John M. Rouhana,Chiara Sabatti,Ashis Saha,Andrew D. Skol,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Nicole A. Teran,Ana Viñuela,Gao Wang,Xiaoquan Wen,Fred A. Wright,Valentin Wucher,Yuxin Zou,Pedro G. Ferreira,Gen Li,Marta Melé,Esti Yeger-Lotem,Mary Barcus,Debra Bradbury,Tanya Krubit,Jeffrey McLean,Liqun Qi,Karna Robinson,Nancy Roche,Anna M. Smith,Leslie H. Sobin,David Tabor,Anita H. Undale,Jason Bridge,Lori E. Brigham,Barbara A. Foster,Bryan Gillard,Richard Hasz,Marcus Hunter,Christopher Johns,Mark H. Johnson,Ellen Karasik,Gene Kopen,William F. Leinweber,Alisa McDonald,Michael T. Moser,Kevin Myer,Kimberley Ramsey,Brian Roe,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Joseph Wheeler,Scott D. Jewell,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Philip A. Branton,Laura Barker,Heather M. Gardiner,Maghboeba Mosavel,Laura A. Siminoff,Paul Flicek,Maximilian Haeussler,Thomas Juettemann,W. James Kent,Christopher Lee,Conner C. Powell,Kate R. Rosenbloom,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Nathan S. Abell,Joshua M. Akey,Lin Chen,Kathryn Demanelis,Jennifer A. Doherty,Andrew P. Feinberg,Kasper D. Hansen,Peter Hickey,Farzana Jasmine,Lihua Jiang,Rajinder Kaul,Muhammad G. Kibriya,Jin Billy Li,Qin Li,Shin Lin,Sandra Linder,Brandon L. Pierce,Lindsay F. Rizzardi,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Meng Wang,Latarsha J. Carithers,Ping Guan,Susan E. Koester,A. Roger Little,Helen M. Moore,Concepcion R. Nierras,Abhi Rao,Jimmie B. Vaught,Simona Volpi +170 more
TL;DR: A vast AE resource generated from the GTEx v8 release is presented and the utility of this resource is demonstrated, and an extension of the tool phASER is developed that allows effect sizes of cis -regulatory variants to be estimated using haplotype-level AE data.
Journal ArticleDOI
Distinct epigenomic patterns are associated with haploinsufficiency and predict risk genes of developmental disorders.
TL;DR: A Random Forest-based method that uses epigenomic data to predict haploinsufficiency, Episcore, which is complementary to methods based on mutation intolerance scores and enables new applications of epigenomicData and facilitates discovery and interpretation of novel risk variants implicated in developmental disorders.