A
A. Roger Little
Researcher at National Institute on Drug Abuse
Publications - 12
Citations - 2802
A. Roger Little is an academic researcher from National Institute on Drug Abuse. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 8, co-authored 12 publications receiving 2255 citations. Previous affiliations of A. Roger Little include National Institutes of Health.
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Journal ArticleDOI
The NIH Human Microbiome Project
Jane Peterson,Susan Garges,Maria Y. Giovanni,Pamela McInnes,Lu Wang,Jeffery A. Schloss,Vivien Bonazzi,Jean E. McEwen,Kris A. Wetterstrand,Carolyn Deal,Carl C. Baker,Valentina Di Francesco,T. Kevin Howcroft,Robert W. Karp,R. Dwayne Lunsford,Christopher Wellington,Tsegahiwot Belachew,Michael Wright,Christina Giblin,Hagit David,Melody Mills,Rachelle Salomon,Chris Mullins,Beena Akolkar,Lisa Begg,Cindy D. Davis,Lindsey Grandison,Michael C. Humble,Jag H. Khalsa,A. Roger Little,Hannah Peavy,Carol H. Pontzer,Matthew E. Portnoy,Michael H. Sayre,Pamela Starke-Reed,Samir Zakhari,Jennifer S. Read,Bracie Watson,Mark S. Guyer +38 more
TL;DR: The ultimate objective of the HMP is to demonstrate that there are opportunities to improve human health through monitoring or manipulation of the human microbiome.
Journal ArticleDOI
Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.
Alvaro N. Barbeira,Scott P. Dickinson,Rodrigo Bonazzola,Jiamao Zheng,Heather E. Wheeler,Jason M. Torres,Eric S. Torstenson,Kaanan P. Shah,Tzintzuni Garcia,Todd L. Edwards,Eli A. Stahl,Laura M. Huckins,François Aguet,Kristin G. Ardlie,Beryl B. Cummings,Ellen Gelfand,Gad Getz,Kane Hadley,Robert E. Handsaker,Katherine H. Huang,Seva Kashin,Konrad J. Karczewski,Monkol Lek,Xiao Li,Xiao Li,Daniel G. MacArthur,Jared L. Nedzel,Duyen T. Nguyen,Michael S. Noble,Ayellet V. Segrè,Casandra A. Trowbridge,Taru Tukiainen,Nathan S. Abell,Brunilda Balliu,Ruth Barshir,Omer Basha,Alexis Battle,Gireesh K. Bogu,Andrew A. Brown,Andrew A. Brown,Christopher D. Brown,Stephane E. Castel,Lin Chen,Colby Chiang,Donald F. Conrad,Farhan N. Damani,Joe R. Davis,Olivier Delaneau,Olivier Delaneau,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Barbara E. Engelhardt,Eleazar Eskin,Pedro G. Ferreira,Laure Fresard,Eric R. Gamazon,Eric R. Gamazon,Diego Garrido-Martín,Ariel D. H. Gewirtz,Genna Gliner,Michael J. Gloudemans,Roderic Guigó,Ira M. Hall,Buhm Han,Yuan He,Farhad Hormozdiari,Cédric Howald,Cédric Howald,Brian Jo,Eun Yong Kang,Yungil Kim,Sarah Kim-Hellmuth,Tuuli Lappalainen,Gen Li,Xin Li,Boxiang Liu,Serghei Mangul,Mark I. McCarthy,Ian C. McDowell,Pejman Mohammadi,Jean Monlong,Jean Monlong,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Manuel Muñoz-Aguirre,Anne Ndungu,Andrew B. Nobel,Meritxell Oliva,Halit Ongen,Halit Ongen,John Palowitch,Nikolaos I Panousis,Nikolaos I Panousis,Panagiotis Papasaikas,YoSon Park,Princy Parsana,Anthony Payne,Christine B. Peterson,Jie Quan,Ferran Reverter,Ferran Reverter,Chiara Sabatti,Ashis Saha,Michael Sammeth,Alexandra J. Scott,Andrey A. Shabalin,Reza Sodaei,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Jae Hoon Sul,Emily K. Tsang,Sarah Urbut,Martijn van de Bunt,Gao Wang,Xiaoquan Wen,Fred A. Wright,Hualin S. Xi,Esti Yeger-Lotem,Zachary Zappala,Judith B. Zaugg,Yi-Hui Zhou,Joshua M. Akey,Daniel Bates,Joanne Chan,Melina Claussnitzer,Melina Claussnitzer,Kathryn Demanelis,Morgan Diegel,Jennifer A. Doherty,Andrew P. Feinberg,Marian S. Fernando,Jessica Halow,Kasper D. Hansen,Eric Haugen,Peter Hickey,Lei Hou,Lei Hou,Farzana Jasmine,Ruiqi Jian,Lihua Jiang,Audra K. Johnson,Rajinder Kaul,Manolis Kellis,Manolis Kellis,Muhammad G. Kibriya,Kristen Lee,Jin Billy Li,Qin Li,Jessica Lin,Jessica Lin,Shin Lin,Shin Lin,Sandra Linder,Caroline Linke,Yaping Liu,Yaping Liu,Matthew T. Maurano,Benoit Molinie,Jemma Nelson,Fidencio J. Neri,Yongjin Park,Yongjin Park,Brandon L. Pierce,Nicola J. Rinaldi,Nicola J. Rinaldi,Lindsay F. Rizzardi,Richard Sandstrom,Andrew D. Skol,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Li Wang,Meng Wang,Nicholas Van Wittenberghe,Fan Wu,Rui Zhang,Concepcion R. Nierras,Philip A. Branton,Latarsha J. Carithers,Ping Guan,Helen M. Moore,Abhi Rao,Jimmie B. Vaught,Sarah E. Gould,Nicole C. Lockart,Casey Martin,Jeffery P. Struewing,Simona Volpi,Anjené M. Addington,Susan E. Koester,A. Roger Little,Lori E. Brigham,Richard Hasz,Marcus Hunter,Christopher Johns,Mark H. Johnson,Gene Kopen,William F. Leinweber,John T. Lonsdale,Alisa McDonald,Bernadette Mestichelli,Kevin Myer,Brian Roe,Michael F. Salvatore,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Joseph Wheeler,Jason Bridge,Barbara A. Foster,Bryan Gillard,Ellen Karasik,Rachna Kumar,Mark Miklos,Michael T. Moser,Scott D. Jewell,Robert G. Montroy,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Anita H. Undale,Anna M. Smith,David E. Tabor,Nancy Roche,Jeffrey McLean,Negin Vatanian,Karna Robinson,Leslie H. Sobin,Mary Barcus,Kimberly M. Valentino,Liqun Qi,Steven Hunter,Pushpa Hariharan,Shilpi Singh,Ki Sung Um,Takunda Matose,Maria M. Tomaszewski,Laura Barker,Maghboeba Mosavel,Laura A. Siminoff,Heather M. Traino,Paul Flicek,Thomas Juettemann,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Brian Craft,Mary Goldman,Maximilian Haeussler,W. James Kent,Christopher Lee,Benedict Paten,Kate R. Rosenbloom,John Vivian,Jingchun Zhu,Dan L. Nicolae,Nancy J. Cox,Hae Kyung Im +263 more
TL;DR: A mathematical expression is derived to compute PrediXcan results using summary data, and the effects of gene expression variation on human phenotypes in 44 GTEx tissues and >100 phenotypes are investigated.
Journal ArticleDOI
Co-expression networks reveal the tissue-specific regulation of transcription and splicing
Ashis Saha,Yungil Kim,Ariel D. H. Gewirtz,Brian Jo,Chuan Gao,Ian C. McDowell,Barbara E. Engelhardt,Alexis Battle,François Aguet,Kristin G. Ardlie,Beryl B. Cummings,Beryl B. Cummings,Ellen Gelfand,Gad Getz,Gad Getz,Kane Hadley,Robert E. Handsaker,Robert E. Handsaker,Katherine H. Huang,Seva Kashin,Seva Kashin,Konrad J. Karczewski,Konrad J. Karczewski,Monkol Lek,Monkol Lek,Xiao Li,Daniel G. MacArthur,Daniel G. MacArthur,Jared L. Nedzel,Duyen T. Nguyen,Michael S. Noble,Ayellet V. Segrè,Casandra A. Trowbridge,Taru Tukiainen,Taru Tukiainen,Nathan S. Abell,Brunilda Balliu,Ruth Barshir,Omer Basha,Gireesh K. Bogu,Andrew A. Brown,Andrew A. Brown,Christopher D. Brown,Stephane E. Castel,Lin Chen,Colby Chiang,Donald F. Conrad,Nancy J. Cox,Farhan N. Damani,Joe R. Davis,Olivier Delaneau,Olivier Delaneau,Emmanouil T. Dermitzakis,Emmanouil T. Dermitzakis,Eleazar Eskin,Pedro G. Ferreira,Laure Fresard,Eric R. Gamazon,Eric R. Gamazon,Diego Garrido-Martín,Genna Gliner,Michael J. Gloudemans,Roderic Guigó,Ira M. Hall,Buhm Han,Yuan He,Farhad Hormozdiari,Cédric Howald,Cédric Howald,Hae Kyung Im,Eun Yong Kang,Sarah Kim-Hellmuth,Tuuli Lappalainen,Gen Li,Xin Li,Boxiang Liu,Serghei Mangul,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Pejman Mohammadi,Jean Monlong,Jean Monlong,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Manuel Muñoz-Aguirre,Anne Ndungu,Dan L. Nicolae,Andrew B. Nobel,Meritxell Oliva,Halit Ongen,Halit Ongen,John Palowitch,Nikolaos I Panousis,Nikolaos I Panousis,Panagiotis Papasaikas,YoSon Park,Princy Parsana,Anthony Payne,Christine B. Peterson,Jie Quan,Ferran Reverter,Ferran Reverter,Chiara Sabatti,Michael Sammeth,Alexandra J. Scott,Andrey A. Shabalin,Reza Sodaei,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Jae Hoon Sul,Emily K. Tsang,Sarah Urbut,Martijn van de Bunt,Martijn van de Bunt,Gao Wang,Xiaoquan Wen,Fred A. Wright,Hualin S. Xi,Esti Yeger-Lotem,Zachary Zappala,Judith B. Zaugg,Yi-Hui Zhou,Joshua M. Akey,Daniel Bates,Joanne Chan,Melina Claussnitzer,Melina Claussnitzer,Melina Claussnitzer,Kathryn Demanelis,Morgan Diegel,Jennifer A. Doherty,Andrew P. Feinberg,Marian S. Fernando,Jessica Halow,Kasper D. Hansen,Kasper D. Hansen,Eric Haugen,Peter Hickey,Lei Hou,Farzana Jasmine,Ruiqi Jian,Lihua Jiang,Audra K. Johnson,Rajinder Kaul,Manolis Kellis,Muhammad G. Kibriya,Kristen Lee,Jin Billy Li,Qin Li,Jessica Lin,Jessica Lin,Shin Lin,Shin Lin,Sandra Linder,Caroline Linke,Yaping Liu,Matthew T. Maurano,Benoit Molinie,Jemma Nelson,Fidencio J. Neri,Yongjin Park,Brandon L. Pierce,Nicola J. Rinaldi,Lindsay F. Rizzardi,Richard Sandstrom,Andrew D. Skol,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Li Wang,Meng Wang,Nicholas Van Wittenberghe,Fan Wu,Rui Zhang,Concepcion R. Nierras,Philip A. Branton,Latarsha J. Carithers,Ping Guan,Helen M. Moore,Abhi Rao,Jimmie B. Vaught,Sarah E. Gould,Nicole C. Lockart,Casey Martin,Jeffery P. Struewing,Simona Volpi,Anjené M. Addington,Susan E. Koester,A. Roger Little,Lori E. Brigham,Richard Hasz,Marcus Hunter,Christopher Johns,Mark D. Johnson,Gene Kopen,William F. Leinweber,John T. Lonsdale,Alisa McDonald,Bernadette Mestichelli,Kevin Myer,Brian Roe,Michael F. Salvatore,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Joseph Wheeler,Jason Bridge,Barbara A. Foster,Bryan Gillard,Ellen Karasik,Rachna Kumar,Mark Miklos,Michael T. Moser,Scott D. Jewell,Robert G. Montroy,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Anita H. Undale,Anna M. Smith,David E. Tabor,Nancy Roche,Jeffrey McLean,Negin Vatanian,Karna Robinson,Leslie H. Sobin,Mary Barcus,Kimberly M. Valentino,Liqun Qi,Steven Hunter,Pushpa Hariharan,Shilpi Singh,Ki Sung Um,Takunda Matose,Maria M. Tomaszewski,Laura Barker,Maghboeba Mosavel,Laura A. Siminoff,Heather M. Traino,Paul Flicek,Thomas Juettemann,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Brian Craft,Mary Goldman,Maximilian Haeussler,W. James Kent,Christopher Lee,Benedict Paten,Kate R. Rosenbloom,John Vivian,Jingchun Zhu +259 more
TL;DR: These networks are built that additionally capture the regulation of relative isoform abundance and splicing, along with tissue-specific connections unique to each of a diverse set of tissues, and provide an improved understanding of the complex relationships of the human transcriptome across tissues.
Journal ArticleDOI
Perspective: Dietary Biomarkers of Intake and Exposure-Exploration with Omics Approaches.
Padma Maruvada,Johanna W. Lampe,Johanna W. Lampe,David S. Wishart,Dinesh Kumar Barupal,Deirdra N. Chester,Dylan Dodd,Yannick Djoumbou-Feunang,Pieter C. Dorrestein,Pieter C. Dorrestein,Lars O. Dragsted,John Draper,Linda C. Duffy,Johanna T. Dwyer,Nancy J. Emenaker,Oliver Fiehn,Robert E. Gerszten,Frank B. Hu,Frank B. Hu,Robert W. Karp,David M. Klurfeld,Maren R. Laughlin,A. Roger Little,Christopher J. Lynch,Steven C. Moore,Holly L. Nicastro,Diane M. O'Brien,Jose M. Ordovas,Stavroula K. Osganian,Mary C. Playdon,Ross L. Prentice,Ross L. Prentice,Daniel Raftery,Daniel Raftery,Nichole Reisdorph,Helen M. Roche,Sharon A. Ross,Shengmin Sang,Augustin Scalbert,Pothur R. Srinivas,Steven H. Zeisel +40 more
TL;DR: The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research.
Journal ArticleDOI
A vast resource of allelic expression data spanning human tissues
Stephane E. Castel,François Aguet,Pejman Mohammadi,Shankara Anand,Kristin G. Ardlie,Stacey Gabriel,Gad Getz,Aaron Graubert,Kane Hadley,Robert E. Handsaker,Katherine H. Huang,Seva Kashin,Xiao Li,Daniel G. MacArthur,Sam Meier,Jared L. Nedzel,Duyen T. Nguyen,Ayellet V. Segrè,Ellen Todres,Brunilda Balliu,Alvaro N. Barbeira,Alexis Battle,Rodrigo Bonazzola,Andrew Brown,Christopher D. Brown,Donald F. Conrad,Daniel J. Cotter,Nancy J. Cox,Sayantan Das,Olivia M. De Goede,Emmanouil T. Dermitzakis,Jonah Einson,Barbara E. Engelhardt,Eleazar Eskin,Tiffany Eulalio,Nicole M. Ferraro,Elise D. Flynn,Laure Fresard,Eric R. Gamazon,Diego Garrido-Martín,Michael J. Gloudemans,Roderic Guigó,Andrew R. Hame,Yuan He,Paul J. Hoffman,Farhad Hormozdiari,Lei Hou,Hae Kyung Im,Brian Jo,Silva Kasela,Manolis Kellis,Sarah Kim-Hellmuth,Alan Kwong,Tuuli Lappalainen,Xin Li,Yanyu Liang,Serghei Mangul,Stephen B. Montgomery,Manuel Muñoz-Aguirre,Daniel Nachun,Andrew B. Nobel,Meritxell Oliva,YoSon Park,Yongjin Park,Princy Parsana,Abhiram Rao,Ferran Reverter,John M. Rouhana,Chiara Sabatti,Ashis Saha,Andrew D. Skol,Matthew Stephens,Barbara E. Stranger,Benjamin J. Strober,Nicole A. Teran,Ana Viñuela,Gao Wang,Xiaoquan Wen,Fred A. Wright,Valentin Wucher,Yuxin Zou,Pedro G. Ferreira,Gen Li,Marta Melé,Esti Yeger-Lotem,Mary Barcus,Debra Bradbury,Tanya Krubit,Jeffrey McLean,Liqun Qi,Karna Robinson,Nancy Roche,Anna M. Smith,Leslie H. Sobin,David Tabor,Anita H. Undale,Jason Bridge,Lori E. Brigham,Barbara A. Foster,Bryan Gillard,Richard Hasz,Marcus Hunter,Christopher Johns,Mark H. Johnson,Ellen Karasik,Gene Kopen,William F. Leinweber,Alisa McDonald,Michael T. Moser,Kevin Myer,Kimberley Ramsey,Brian Roe,Saboor Shad,Jeffrey A. Thomas,Gary Walters,Michael Washington,Joseph Wheeler,Scott D. Jewell,Daniel C. Rohrer,Dana R. Valley,David A. Davis,Deborah C. Mash,Philip A. Branton,Laura Barker,Heather M. Gardiner,Maghboeba Mosavel,Laura A. Siminoff,Paul Flicek,Maximilian Haeussler,Thomas Juettemann,W. James Kent,Christopher Lee,Conner C. Powell,Kate R. Rosenbloom,Magali Ruffier,Dan Sheppard,Kieron Taylor,Stephen J. Trevanion,Daniel R. Zerbino,Nathan S. Abell,Joshua M. Akey,Lin Chen,Kathryn Demanelis,Jennifer A. Doherty,Andrew P. Feinberg,Kasper D. Hansen,Peter Hickey,Farzana Jasmine,Lihua Jiang,Rajinder Kaul,Muhammad G. Kibriya,Jin Billy Li,Qin Li,Shin Lin,Sandra Linder,Brandon L. Pierce,Lindsay F. Rizzardi,Kevin S. Smith,Michael Snyder,John A. Stamatoyannopoulos,Hua Tang,Meng Wang,Latarsha J. Carithers,Ping Guan,Susan E. Koester,A. Roger Little,Helen M. Moore,Concepcion R. Nierras,Abhi Rao,Jimmie B. Vaught,Simona Volpi +170 more
TL;DR: A vast AE resource generated from the GTEx v8 release is presented and the utility of this resource is demonstrated, and an extension of the tool phASER is developed that allows effect sizes of cis -regulatory variants to be estimated using haplotype-level AE data.