E
Emmanuel L. Gautier
Researcher at University of Paris
Publications - 73
Citations - 10512
Emmanuel L. Gautier is an academic researcher from University of Paris. The author has contributed to research in topics: Macrophage & Inflammation. The author has an hindex of 35, co-authored 64 publications receiving 8725 citations. Previous affiliations of Emmanuel L. Gautier include Institute of Chartered Accountants of Nigeria & Washington University in St. Louis.
Papers
More filters
Journal ArticleDOI
Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages
Emmanuel L. Gautier,Tal Shay,Tal Shay,Jennifer Miller,Melanie Greter,Claudia Jakubzick,Stoyan Ivanov,Julie Helft,Andrew Chow,Kutlu G. Elpek,Simon Gordonov,Amin R. Mazloom,Avi Ma'ayan,Wei-Jen Chua,Ted H. Hansen,Shannon J. Turley,Miriam Merad,Gwendalyn J. Randolph +17 more
TL;DR: It is identified how well-characterized surface markers, including MerTK and FcγR1 (CD64), along with a cluster of previously unidentified transcripts, were distinctly and universally associated with mature tissue macrophages and how these transcripts and the proteins they encode facilitated distinguishing macrophage from dendritic cells.
Journal ArticleDOI
Embryonic and adult-derived resident cardiac macrophages are maintained through distinct mechanisms at steady state and during inflammation.
Slava Epelman,Kory J. Lavine,Anna E. Beaudin,Dorothy K. Sojka,Javier A. Carrero,Boris Calderon,Thaddeus Brija,Emmanuel L. Gautier,Stoyan Ivanov,Ansuman T. Satpathy,Joel D. Schilling,Reto A. Schwendener,Ismail Sergin,Babak Razani,E. Camilla Forsberg,Wayne M. Yokoyama,Emil R. Unanue,Marco Colonna,Gwendalyn J. Randolph,Douglas L. Mann +19 more
TL;DR: Transcriptional and functional data revealed that monocyte-derived macrophages coordinate cardiac inflammation, while playing redundant but lesser roles in antigen sampling and efferocytosis, and the presence of multiple cardiac macrophage subsets, with different functions, origins, and strategies to regulate compartment size.
Journal ArticleDOI
Minimal Differentiation of Classical Monocytes as They Survey Steady-State Tissues and Transport Antigen to Lymph Nodes
Claudia Jakubzick,Claudia Jakubzick,Emmanuel L. Gautier,Sophie L. Gibbings,Dorothy K. Sojka,Andreas Schlitzer,Theodore E. Johnson,Stoyan Ivanov,Qiaonan Duan,Shashi Bala,Tracy Condon,Nico van Rooijen,John R. Grainger,Yasmine Belkaid,Avi Ma'ayan,David W. H. Riches,Wayne M. Yokoyama,Florent Ginhoux,Peter M. Henson,Gwendalyn J. Randolph,Gwendalyn J. Randolph +20 more
TL;DR: It is shown that Ly-6C⁺ monocytes constitutively trafficked into skin, lung, and lymph nodes (LNs) and can enter steady-state nonlymphoid organs and recirculate to LNs without differentiation to macrophages or DCs, revising a long-held view that monocytes become tissue-resident macrophage by default.
Journal ArticleDOI
Comparison of gene expression profiles between human and mouse monocyte subsets
Molly A. Ingersoll,Rainer Spanbroek,Claudio Lottaz,Emmanuel L. Gautier,Marion Frankenberger,Reinhard Hoffmann,Roland Lang,Muzlifah Haniffa,Matthew Collin,Frank Tacke,Andreas J. R. Habenicht,Loems Ziegler-Heitbrock,Gwendalyn J. Randolph +12 more
TL;DR: Whereas human and mouse monocyte subsets are far more broadly conserved than currently recognized, important differences between the species deserve consideration when models of human disease are studied in mice.
Journal ArticleDOI
Deciphering the transcriptional network of the dendritic cell lineage
Jennifer Miller,Brian D. Brown,Tal Shay,Emmanuel L. Gautier,Emmanuel L. Gautier,Vladimir Jojic,Vladimir Jojic,Ariella Cohain,Gaurav Pandey,Marylene Leboeuf,Kutlu G. Elpek,Julie Helft,Daigo Hashimoto,Andrew Chow,Andrew Chow,Jeremy Price,Melanie Greter,Melanie Greter,Milena Bogunovic,Angelique Bellemare-Pelletier,Paul S. Frenette,Gwendalyn J. Randolph,Gwendalyn J. Randolph,Shannon J. Turley,Miriam Merad +24 more
TL;DR: A transcriptional program expressed specifically during the steady-state migration of tissue DCs to the draining lymph nodes that may control tolerance to self tissue antigens is identified and predicted regulators of DC functional diversity in tissues are predicted.