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Ennio Tasciotti
Researcher at Houston Methodist Hospital
Publications - 216
Citations - 9469
Ennio Tasciotti is an academic researcher from Houston Methodist Hospital. The author has contributed to research in topics: Drug delivery & Tissue engineering. The author has an hindex of 42, co-authored 212 publications receiving 7526 citations. Previous affiliations of Ennio Tasciotti include University of Akron & Open University.
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Journal ArticleDOI
Synthetic nanoparticles functionalized with biomimetic leukocyte membranes possess cell-like functions
Alessandro Parodi,Nicoletta Quattrocchi,Nicoletta Quattrocchi,Anne L. van de Ven,Ciro Chiappini,Michael Evangelopoulos,Jonathan O. Martinez,Jonathan O. Martinez,Brandon S. Brown,Brandon S. Brown,Sm Z. Khaled,Iman K. Yazdi,Iman K. Yazdi,Maria Vittoria Enzo,Maria Vittoria Enzo,Lucas Isenhart,Mauro Ferrari,Ennio Tasciotti +17 more
TL;DR: It is shown that nanoporous silicon particles can successfully perform all actions when they are coated with cellular membranes purified from leukocytes, and leukolike vectors retained their functions when injected in vivo, showing enhanced circulation time and improved accumulation in a tumour.
Journal ArticleDOI
Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications
Ennio Tasciotti,Xuewu Liu,Rohan Bhavane,Kevin D. Plant,Ashley D. Leonard,B. Katherine Price,Mark Ming-Cheng Cheng,Paolo Decuzzi,James M. Tour,Fredika M. Robertson,Mauro Ferrari,Mauro Ferrari,Mauro Ferrari +12 more
TL;DR: A multistage delivery system that can carry, release over time and deliver two types of nanoparticles into primary endothelial cells is shown, based on biodegradable and biocompatible mesoporous silicon particles that have well-controlled shapes, sizes and pores.
Journal ArticleDOI
The impact of nanoparticle protein corona on cytotoxicity, immunotoxicity and target drug delivery.
Claudia Corbo,Roberto Molinaro,Alessandro Parodi,Naama E. Toledano Furman,Francesco Salvatore,Ennio Tasciotti +5 more
TL;DR: A survey of recent findings on the NP-PC interactions is provided and how the PC can be used to modulate both cytotoxicity and the immune response as well as to improve the efficacy of targeted delivery of nanocarriers is discussed.
Journal ArticleDOI
Biodegradable silicon nanoneedles delivering nucleic acids intracellularly induce localized in vivo neovascularization
Ciro Chiappini,E. De Rosa,Jonathan O. Martinez,Xuewu Liu,Joseph A. M. Steele,Molly M. Stevens,Ennio Tasciotti +6 more
TL;DR: It is shown that a tunable array of biodegradable nan oneedles fabricated by metal-assisted chemical etching of silicon can access the cytosol to co-deliver DNA and siRNA with an efficiency greater than 90%, and that in vivo the nanoneedles transfect the VEGF-165 gene, inducing sustained neovascularization and a localized sixfold increase in blood perfusion in a target region of the muscle.
Journal ArticleDOI
Biomimetic proteolipid vesicles for targeting inflamed tissues
Roberto Molinaro,Claudia Corbo,Jonathan O. Martinez,Francesca Taraballi,Michael Evangelopoulos,Silvia Minardi,Iman K. Yazdi,Picheng Zhao,E. De Rosa,Michael B. Sherman,A. De Vita,N. E. Toledano Furman,Xin Wang,Alessandro Parodi,Ennio Tasciotti +14 more
TL;DR: A method is described that leverages the advantages of bottom-up and top-down strategies to incorporate proteins derived from the leukocyte plasma membrane into lipid nanoparticles that retained the versatility and physicochemical properties typical of liposomal formulations and enabled the selective and effective delivery of dexamethasone to inflamed tissues.