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Ernest A. Kopecky
Researcher at University of Toronto
Publications - 39
Citations - 1554
Ernest A. Kopecky is an academic researcher from University of Toronto. The author has contributed to research in topics: Oxycodone & Chronic pain. The author has an hindex of 18, co-authored 39 publications receiving 1276 citations.
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Journal ArticleDOI
Patient phenotyping in clinical trials of chronic pain treatments: IMMPACT recommendations.
Robert R. Edwards,Robert H. Dworkin,Dennis C. Turk,Martin S. Angst,Raymond A. Dionne,Roy Freeman,Per Hansson,Simon Haroutounian,Lars Arendt-Nielsen,Nadine Attal,R. Baron,Joanna M. Brell,Shay Bujanover,Laurie B. Burke,Daniel B. Carr,Amy S. Chappell,Penney Cowan,Mila Etropolski,Roger B. Fillingim,Jennifer S. Gewandter,Nathaniel P. Katz,Ernest A. Kopecky,John D. Markman,George G. Nomikos,Linda Porter,Bob A. Rappaport,Andrew S.C. Rice,Joseph M. Scavone,Joachim Scholz,Lee S. Simon,Shannon M. Smith,Jeffrey Tobias,Tina Tockarshewsky,Christine Veasley,Mark Versavel,Ajay D. Wasan,Warren Wen,David Yarnitsky +37 more
TL;DR: Evidence is presented on the most promising phenotypic characteristics of patients that are most predictive of individual variation in analgesic treatment outcomes, and the measurement tools that are best suited to evaluate these characteristics.
Journal ArticleDOI
Classification and definition of misuse, abuse, and related events in clinical trials: ACTTION systematic review and recommendations
Shannon M. Smith,Richard C. Dart,Nathaniel P. Katz,Florence Paillard,Edgar H. Adams,Sandra D. Comer,Aldemar Degroot,Robert R. Edwards,J. David Haddox,J. David Haddox,Jerome H. Jaffe,Christopher M. Jones,Herbert D. Kleber,Ernest A. Kopecky,John D. Markman,Ivan D. Montoya,Charles A. O'Brien,Carl L. Roland,Marsha Stanton,Eric C. Strain,G. Vorsanger,Ajay D. Wasan,Roger D. Weiss,Dennis C. Turk,Robert H. Dworkin +24 more
TL;DR: The proposed ACTTION classifications and definitions are designed as a first step in a system to adjudicate MAREs that occur in analgesic clinical trials and postmarketing adverse event surveillance and monitoring, which can be used in conjunction with other methods of assessing a treatment’s abuse potential.
Journal ArticleDOI
Assessment of physical function and participation in chronic pain clinical trials: IMMPACT/OMERACT recommendations
Ann Margaret Taylor,Kristine Phillips,Kushang V. Patel,Dennis C. Turk,Robert H. Dworkin,Dorcas E. Beaton,Daniel J. Clauw,Monique A. M. Gignac,John D. Markman,David A. Williams,Shay Bujanover,Laurie B. Burke,Daniel B. Carr,Ernest Choy,Philip G. Conaghan,Penney Cowan,John T. Farrar,Roy Freeman,Jennifer S. Gewandter,Ian Gilron,Veeraindar Goli,Veeraindar Goli,Tony D. Gover,J. David Haddox,Robert D. Kerns,Robert D. Kerns,Ernest A. Kopecky,David A. Lee,Richard Malamut,Philip J. Mease,Philip J. Mease,Bob A. Rappaport,Lee S. Simon,Jasvinder A. Singh,Jasvinder A. Singh,Shannon M. Smith,Vibeke Strand,Peter Tugwell,Gertrude F. Vanhove,Christin Veasley,Gary A. Walco,Ajay D. Wasan,James Witter +42 more
TL;DR: Support is provided for the use of reliable and valid PROs and performance-based measures of physical functioning, covering broad aspects of functioning, including work participation, social participation, and caregiver burden, which researchers should consider when designing chronic pain clinical trials.
Journal ArticleDOI
The Potential Role of Sensory Testing, Skin Biopsy, and Functional Brain Imaging as Biomarkers in Chronic Pain Clinical Trials: IMMPACT Considerations
Shannon M. Smith,Robert H. Dworkin,Dennis C. Turk,Ralf Baron,Michael Polydefkis,Irene Tracey,David Borsook,Robert R. Edwards,Richard E. Harris,Tor D. Wager,Lars Arendt-Nielsen,Laurie B. Burke,Daniel B. Carr,Amy S. Chappell,John T. Farrar,Roy Freeman,Ian Gilron,Veeraindar Goli,Juergen Haeussler,Troels S. Jensen,Nathaniel P. Katz,Jeffrey Kent,Ernest A. Kopecky,David A. Lee,William Maixner,John D. Markman,Justin C. McArthur,Michael P. McDermott,Lav K. Parvathenani,Srinivasa N. Raja,Bob A. Rappaport,Andrew S.C. Rice,Michael C. Rowbotham,Jeffrey Tobias,Ajay D. Wasan,James Witter +35 more
TL;DR: Although sensory testing, skin punch biopsy, and brain imaging are promising tools for pain in clinical trials, additional evidence is needed to further support and standardize these tests for use as biomarkers in pain clinical trials.
Journal ArticleDOI
Pregnancy outcome following maternal organic solvent exposure: A meta‐analysis of epidemiologic studies
TL;DR: Maternal occupational exposure to organic solvents is associated with a tendency toward an increased risk for spontaneous abortion and additional studies may affect the trend.