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Paul Coupland
Researcher at Wellcome Trust Sanger Institute
Publications - 17
Citations - 4048
Paul Coupland is an academic researcher from Wellcome Trust Sanger Institute. The author has contributed to research in topics: DNA sequencing & Illumina dye sequencing. The author has an hindex of 15, co-authored 16 publications receiving 3595 citations. Previous affiliations of Paul Coupland include Cardiff University.
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Journal ArticleDOI
A tale of three next generation sequencing platforms: comparison of Ion Torrent, Pacific Biosciences and Illumina MiSeq sequencers.
Michael A. Quail,Miriam Smith,Paul Coupland,Thomas D. Otto,Simon R. Harris,Thomas R. Connor,Anna Bertoni,Harold Swerdlow,Yong Gu +8 more
TL;DR: All three fast turnaround sequencers evaluated here were able to generate usable sequence, however there are key differences between the quality of that data and the applications it will support.
Journal ArticleDOI
G&T-seq: parallel sequencing of single-cell genomes and transcriptomes
Iain C. Macaulay,Wilfried Haerty,Parveen Kumar,Yang I. Li,Yang I. Li,Tim Xiaoming Hu,Mabel J Teng,Mubeen Goolam,Nathalie Saurat,Paul Coupland,Lesley Shirley,Miriam Smith,Niels Van der Aa,Ruby Banerjee,Peter D. Ellis,Michael A. Quail,Harold Swerdlow,Harold Swerdlow,Magdalena Zernicka-Goetz,Frederick J. Livesey,Chris P. Ponting,Chris P. Ponting,Thierry Voet,Thierry Voet +23 more
TL;DR: G&T-seq, a method for separating and sequencing genomic DNA and full-length mRNA from single cells, is described and cellular properties that could not be inferred from DNA or RNA sequencing alone are discovered.
Journal ArticleDOI
Combined hereditary and somatic mutations of replication error repair genes result in rapid onset of ultra-hypermutated cancers.
Adam Shlien,Brittany Campbell,Richard de Borja,Ludmil B. Alexandrov,Daniele Merico,David C. Wedge,Peter Van Loo,Patrick S. Tarpey,Paul Coupland,Sam Behjati,Aaron Pollett,Tatiana Lipman,Abolfazl Heidari,Shriya Deshmukh,Na'ama Avitzur,Bettina Meier,Moritz Gerstung,Ye Hong,Diana M. Merino,Manasa Ramakrishna,Marc Remke,Roland Arnold,Gagan B. Panigrahi,Neha P. Thakkar,Karl P. Hodel,Erin E. Henninger,A. Yasemin Göksenin,Doua Bakry,George S. Charames,Harriet Druker,Jordan Lerner-Ellis,Matthew Mistry,Rina Dvir,Ronald Grant,Ronit Elhasid,Roula Farah,Glenn Taylor,Paul C. Nathan,Sarah Alexander,Shay Ben-Shachar,Simon C. Ling,Steven Gallinger,Shlomi Constantini,Peter B. Dirks,Annie Huang,Stephen W. Scherer,Richard Grundy,Carol Durno,Melyssa Aronson,Anton Gartner,M. Stephen Meyn,Michael D. Taylor,Zachary F. Pursell,Christopher E. Pearson,David Malkin,P. Andrew Futreal,Michael R. Stratton,Eric Bouffet,Cynthia Hawkins,Peter J. Campbell,Uri Tabori +60 more
TL;DR: A new mechanism of cancer progression is suggested in which mutations develop in a rapid burst after ablation of replication repair, which implies a threshold compatible with cancer-cell survival.
Journal ArticleDOI
Transcriptional diversity during lineage commitment of human blood progenitors
Lu Chen,Lu Chen,Lu Chen,Myrto Kostadima,Myrto Kostadima,Myrto Kostadima,Joost H.A. Martens,Giovanni Canu,Giovanni Canu,Sara P. Garcia,Sara P. Garcia,Ernest Turro,Ernest Turro,Kate Downes,Kate Downes,Iain C. Macaulay,Ewa Bielczyk-Maczyńska,Ewa Bielczyk-Maczyńska,Sophia Coe,Sophia Coe,Samantha Farrow,Samantha Farrow,Pawan Poudel,Pawan Poudel,Frances Burden,Frances Burden,Sjoert B. G. Jansen,Sjoert B. G. Jansen,William J. Astle,William J. Astle,Antony P. Attwood,Antony P. Attwood,Tadbir K. Bariana,Bernard de Bono,Bernard de Bono,Alessandra Breschi,John C. Chambers,John C. Chambers,Fizzah A. Choudry,Fizzah A. Choudry,Laura Clarke,Paul Coupland,Martijn van der Ent,Wendy N. Erber,Joop H. Jansen,Rémi Favier,Matthew Fenech,Nicola Foad,Nicola Foad,Kathleen Freson,Chris Van Geet,Keith Gomez,Roderic Guigó,Daniel Hampshire,Daniel Hampshire,Anne M. Kelly,Anne M. Kelly,Anne M. Kelly,Hindrik H. D. Kerstens,Jaspal S. Kooner,Jaspal S. Kooner,Michael Laffan,Claire Lentaigne,Charlotte Labalette,Charlotte Labalette,Tiphaine Martin,Tiphaine Martin,Tiphaine Martin,Stuart Meacham,Stuart Meacham,Andrew D Mumford,Sylvia T. Nurnberg,Sylvia T. Nurnberg,Emilio Palumbo,Bert A. van der Reijden,David J. Richardson,Stephen John Sammut,Greg Slodkowicz,Asif U. Tamuri,Louella Vasquez,Katrin Voss,Katrin Voss,Stephen Watt,Sarah K Westbury,Paul Flicek,Paul Flicek,Remco Loos,Nick Goldman,Paul Bertone,Paul Bertone,Randy J. Read,Sylvia Richardson,Ana Cvejic,Ana Cvejic,Nicole Soranzo,Nicole Soranzo,Willem H. Ouwehand,Willem H. Ouwehand,Willem H. Ouwehand,Hendrik G. Stunnenberg,Mattia Frontini,Mattia Frontini,Augusto Rendon,Augusto Rendon +103 more
TL;DR: A previously undetected layer of regulation affecting cell fating is unveiled, which involves transcriptional isoforms switching without noticeable changes at the gene level and resulting in the gain or loss of protein functions in blood cells involved in the immune system.
Supplementary resources_Transcriptional diversity during lineage commitment of human blood progenitors
Lu Chen,Myrto Kostadima,Joost H.A. Martens,Giovanni Canu,Sara P. Garcia,Ernest Turro,Kate Downes,Iain C. Macaulay,E. Bielczyk Maczynska,S. Coe,Samantha Farrow,Pawan Poudel,Frances Burden,Sjoert B. G. Jansen,William J. Astle,Antony P. Attwood,Tadbir K. Bariana,B. de Bono,Alessandra Breschi,John C. Chambers,Fizzah A. Choudry,Laura Clarke,Paul Coupland,M. van der Ent,Wendy N. Erber,Joop H. Jansen,Rémi Favier,Matthew Fenech,Nicola Foad,Kathleen Freson,C. van Geet,Keith Gomez,Roderic Guigó,D. Hampshire,Anne M. Kelly,Hindrik H. D. Kerstens,Jaspal S. Kooner,Michael Laffan,Claire Lentaigne,Charlotte Labalette,Tiphaine Martin,Stuart Meacham,Andrew D Mumford,Sylvia T. Nurnberg,Emilio Palumbo,B. A. van der Reijden,David J. Richardson,Stephen John Sammut,Greg Slodkowicz,Asif U. Tamuri,Louella Vasquez,Katrin Voss,Stephen Watt,Sarah K Westbury,Paul Flicek,Remco Loos,Nick Goldman,P. Bertone,Randy J. Read,Sylvia Richardson,Ana Cvejic,Nicole Soranzo,Willem H. Ouwehand,Hendrik G. Stunnenberg,Mattia Frontini,Augusto Rendon +65 more