E
Eugene Braunwald
Researcher at Brigham and Women's Hospital
Publications - 1758
Citations - 278949
Eugene Braunwald is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Myocardial infarction & TIMI. The author has an hindex of 230, co-authored 1711 publications receiving 264576 citations. Previous affiliations of Eugene Braunwald include Boston University & University of California, San Francisco.
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Journal ArticleDOI
High dose intravenous streptokinase for acute myocardial infarction: preliminary results of a multicenter trial
L. David Hillis,Jeffrey S. Borer,Eugene Braunwald,James H. Chesebro,Lawrence S. Cohen,James Dalen,Harold T. Dodge,Charles K. Francis,Genell L. Knatterud,Philip Ludbrook,John E. Markis,Hiltrud Mueller,Patrice Desvigne-Nickens,Eugene R. Passamani,Eric R. Powers,A. Koneti Rao,Robert L. Roberts,William C. Roberts,Allan M Ross,Thomas J. Ryan,Burton E. Sobel,David O. Williams,Barry L. Zaret,Co-Investigators +23 more
TL;DR: When given to patients with acute myocardial infarction and total coronary occlusion an average of 4 1/2 hours after the onset of chest pain, high dose intravenous streptokinase achieves reperfusions in only about 40% and results in sustained reperfusion in onlyAbout 30%.
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Discrete subaortic stenosis complicated by aortic valvular regurgitation. clinical, hemodynamic, and pathologic studies and the results of operative treatment.
TL;DR: Four patients are described in whom combined aortic stenosis and regurgitation was evident on examination, and results of the preoperative hemodynamic and angiographic studies that established the diagnosis are presented.
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Prospective ARNI vs. ACE inhibitor trial to DetermIne Superiority in reducing heart failure Events after Myocardial Infarction (PARADISE-MI): design and baseline characteristics
Karola S. Jering,Brian Claggett,Marc A. Pfeffer,Christopher B. Granger,Lars Køber,Eldrin F. Lewis,Aldo P. Maggioni,Douglas L. Mann,John J.V. McMurray,Jean L. Rouleau,Scott D. Solomon,Philippe Gabriel Steg,Peter van der Meer,Margaret Wernsing,Katherine Carter,Weinong Guo,Yinong Zhou,Martin Lefkowitz,Jianjian Gong,Yi Wang,Béla Merkely,Stella M. Macin,Urmil Shah,Jose C. Nicolau,Eugene Braunwald +24 more
TL;DR: The PARADISE-MI trial as discussed by the authors, a double-blind, active-controlled trial, randomized patients within 0.5-7 days of presentation with index myocardial infarction to sacubitril/valsartan or ramipril.
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Mortality in Patients with Atrial Fibrillation Randomized to Edoxaban or Warfarin: Insights from the ENGAGE AF-TIMI 48 Trial
Robert P. Giugliano,Christian T. Ruff,Stephen D. Wiviott,Francesco Nordio,Sabina A. Murphy,Johannes A.N. Kappelhof,Minggao Shi,Michele Mercuri,Elliott M. Antman,Eugene Braunwald +9 more
TL;DR: Fewer total and cardiovascular deaths were observed with edoxaban as compared with warfarin in the ENGAGE AF-TIMI 48 trial, and this predominantly resulted from the significantly lower rate of major bleeding with Edoxaban.
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Neurotransmitter Control of Sinoatrial Pacemaker Frequency in Isolated Rat Atria and in Intact Rabbits
TL;DR: It is concluded that the predominance of the parasympathetic nervous system on the sinoatrial frequency is a result of the interaction of the neurotransmitters, norepinephrine and acetylcholine on the mesthetized rabbits.