Eugene Braunwald

TL;DR: Experimental observations suggested that acutely increased resistance to left ventricular ejection in patients with mitral regurgitation should also result in an elevation of left atrial pressure, and it was considered desirable to determine the effects of elevated aortic pressure on the left atrium pressure pulse in animals before and after the production of experimental mitral Regurgitation.

TL;DR: Prostaglandin compounds have been used therapeutically in recent years for the induction of labor and therapeutic abortions, and their use has been suggested in the treatment of infertility, peptic ulcer, asthma, shock, hypertension and congestive heart failure.

TL;DR: The poor outcome of patients with non-Q wave MI presenting with either ST segment depression or severe ST segment elevation on admission suggests that patients in these subgroups should receive close surveillance and should possibly be considered for aggressive therapy.

TL;DR: The Pl A1,A2 genotype was associated with an excess of recurrent coronary events in patients after MI who did not receive pravastatin, and the ACE D allele added to this risk.

TL;DR: In this paper, elevated Galectin-3 (Gal-3) levels would identify patients with more advanced heart failure (HF) with preserved ejection fraction (HFpEF) as assessed by key pathophysiological domains.