F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Inhibition of the binding of HCV serum particles to human hepatocytes by E1E2-specific D32.10 monoclonal antibody.
Ndiémé Ndongo,Ndiémé Ndongo,Yassine Rechoum,Sylvie De Sequeira,Sylvie De Sequeira,Fabien Zoulim,Fabien Zoulim,Christian Trepo,Christian Trepo,Emmanuel Drouet,Marie-Anne Petit,Marie-Anne Petit +11 more
TL;DR: An in vitro direct cell‐binding assay based on the attachment of radiolabeled HCVsp was developed, and Scatchard plots were used to analyze ligand–receptor binding data, which supports the involvement of the E1E2/D32.10 discontinuous antigenic determinant in the interactions between human hepatocytes andHCVsp, and suggests that D32.
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Performance of the cobas® HBV RNA automated investigational assay for the detection and quantification of circulating HBV RNA in chronic HBV patients.
Caroline Scholtes,Aaron T. Hamilton,Marie-Laure Plissonnier,Caroline Charre,Beth Scott,Ling Wang,Françoise Berby,Janine French,Barbara Testoni,Alan Blair,Miroslava Subic,Matthias Hoppler,Andreas Lankenau,Andreas Grubenmann,Massimo Levrero,Marintha L. Heil,Fabien Zoulim +16 more
TL;DR: For example, the Roche cobas® 6800/8800 analyzer as discussed by the authors was used for quantification of circulating hepatitis B RNA (cirB-RNA), which is a promising biomarker for monitoring antiviral treatment.
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CRISPR-Cas9 Targeting of Hepatitis B Virus Covalently Closed Circular DNA Generates Transcriptionally Active Episomal Variants
Maria Guadalupe Martinez,Emmanuel Combe,Aurore Inchauspé,Philippe E. Mangeot,Elodie Delberghe,Fleur Chapus,Gregory Neveu,Antoine Alam,Kara Carter,Barbara Testoni,Fabien Zoulim +10 more
TL;DR: In this article , the fate of covalently closed circular DNA (cccDNA) was determined after gene editing with CRISPR-Cas9 and showed that the effects induced by Cas9 were sustainable after RNP degradation/loss of detection, suggesting permanent changes in the HBV genome instead of transient effects due to transcriptional interference.
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Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus
M-L Plissonnier,Thomas Lahlali,Marc-Steffen Raab,Maud Michelet,Cristina Romero-López,Michel Rivoire,Klaus Strebhardt,David Durantel,Massimo Levrero,Patrick Mehlen,Fabien Zoulim,Romain Parent +11 more
TL;DR: While the UNC5A dependence receptor counteracts HCV persistence through regulation of autophagy in a DAPK-dependent manner, it is dramatically decreased in all instances in HCC samples, and specifically by HCV in cirrhosis.
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Benefit of direct-acting antiviral therapy for hepatitis C virus (HCV) in monoinfected and HIV-HCV-coinfected patients with mixed cryoglobulinaemia.
Patrick Miailhes,K. Hartig-Lavie,Victor Virlogeux,Pierre Pradat,M. Diakite,A.-C. Uhres,Fabien Zoulim,M.-N. Sarda +7 more
TL;DR: DAA-induced SVR allows cryoglobulin clearance in two-thirds of patients, and this therapy improves clinical outcome of HCV infection with sustained virological response rates above 90%.