F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Journal ArticleDOI
Hepatitis B Virus X Protein Stimulates Gene Expression Selectively From Extrachromosomal DNA Templates
Pieter C van Breugel,Eva Isabelle Robert,Henrik Mueller,Adrien Decorsiere,Fabien Zoulim,Olivier Hantz,Michel Strubin +6 more
TL;DR: It is proposed that HBx supports HBV gene expression by a conserved mechanism that acts specifically on episomal DNA templates independently of the nature of the cis‐regulatory sequences.
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In vitro characterization of viral fitness of therapy-resistant hepatitis B variants.
Stéphanie Villet,Gaëtan Billioud,Gaëtan Billioud,Christian Pichoud,Christian Pichoud,Julie Lucifora,Julie Lucifora,Olivier Hantz,Olivier Hantz,Camille Sureau,Paul Dény,Paul Dény,Fabien Zoulim,Fabien Zoulim +13 more
TL;DR: Understanding HBV mutant selection in vivo will help to optimize new anti-HBV therapeutic strategies and illustrate the importance of viral fitness and infectivity as a major determinant of antiviral therapy resistance in patients.
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Synthesis of 1,2,3-triazolo-carbanucleoside analogues of ribavirin targeting an HCV in replicon.
Yoshio Saito,Vanessa Escuret,David Durantel,Fabien Zoulim,Raymond F. Schinazi,Luigi A. Agrofoglio +5 more
TL;DR: The synthesis of carbocyclic and phosphonocarbocyClic analogues of ribavirin, an anti-HCV inhibitor, are described and displayed a moderate IC(50) against HIV-1 and 37 microM, respectively.
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Intrafamilial prevalence of hepatitis B virus in Western Brazilian Amazon region : Epidemiologic and biomolecular study
Cirley Lobato,José Tavares-Neto,Márcio Rios-Leite,Christian Trepo,Ludmila Vitvitski,Parviz Parvaz,Fabien Zoulim,Argemiro D'Oliveira,Raymundo Paraná +8 more
TL;DR: Hepatitis B is endemic in the Amazon region and is known to cause fever, diarrhoea, and encephalitis in people infected with the virus.
Journal ArticleDOI
Treatment of hepatitis B virus-infected cells with alpha-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity.
Catalin Lazar,David Durantel,Alina Macovei,Nicole Zitzmann,Fabien Zoulim,Raymond A. Dwek,Norica Branza-Nichita +6 more
TL;DR: The data show for the first time that an active alpha-glucosidase activity is crucial for production of infectious HBV and provide new insights into the controversial role of the M protein in this process.