F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Journal ArticleDOI
Hepatitis C virus-induced hepatocarcinogenesis
TL;DR: There is currently very little experimental evidence for a direct oncogenic role of HCV, and the difficulty to identify HCV proteins and infected liver cells in patients contributes to the complexity of current understanding.
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Hepatitis B Virus Impairs TLR9 Expression and Function in Plasmacytoid Dendritic Cells
Isabelle Vincent,Isabelle Vincent,Claudia Zannetti,Claudia Zannetti,Julie Lucifora,Helene Norder,Ulrike Protzer,Pierre Hainaut,Fabien Zoulim,Fabien Zoulim,Massimo Tommasino,Christian Trepo,Christian Trepo,Uzma Hasan,Uzma Hasan,Isabelle Chemin,Isabelle Chemin +16 more
TL;DR: HBV has developed several escape mechanisms to avoid TLR9 activation in both pDCs and B lymphocytes, which may in turn contribute to the establishment and/or persistence of chronic infection.
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Antiviral Therapies and Prospects for a Cure of Chronic Hepatitis B
Fabien Zoulim,David Durantel +1 more
TL;DR: Adding one or several new drugs to current regimens should offer the prospect of markedly improving the response to therapy, thus reducing the burden of drug resistance, as well as the incidence of cirrhosis and hepatocellular carcinoma.
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Tenofovir Is Effective Alone or With Emtricitabine in Adefovir-Treated Patients With Chronic-Hepatitis B Virus Infection
Thomas Berg,Patrick Marcellin,Fabien Zoulim,Bernd Möller,Huy N. Trinh,Sing Chan,E. Suárez,Fabien Lavocat,Andrea Snow–Lampart,David Frederick,Jeff Sorbel,Katyna Borroto–Esoda,David Oldach,Franck Rousseau +13 more
TL;DR: TDF monotherapy and the combination of FTC and TDF had similar efficacy in patients with incomplete viral suppression after therapy with ADV; response was not influenced by the presence of baseline LAM- or ADV-associated mutations.
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Control of hepatitis B virus replication by innate response of HepaRG cells
Julie Lucifora,Julie Lucifora,David Durantel,David Durantel,David Durantel,Barbara Testoni,Barbara Testoni,Olivier Hantz,Olivier Hantz,Massimo Levrero,Massimo Levrero,Fabien Zoulim,Fabien Zoulim,Fabien Zoulim +13 more
TL;DR: It is demonstrated that HBV elicits a strong and specific innate antiviral response that results in a noncytopathic clearance of HBV DNA in HepaRG cells.