F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Journal ArticleDOI
A Model-Based Illustrative Exploratory Approach to Optimize the Dosing of Peg-IFN/RBV in Cirrhotic Hepatitis C Patients Treated With Triple Therapy.
Cédric Laouénan,Jeremie Guedj,Gilles Peytavin,Thi Huyen Tram Nguyen,M. Lapalus,F. Khelifa-Mouri,Nathalie Boyer,Fabien Zoulim,Lawrence Serfaty,J. P. Bronowicki,Michelle Martinot-Peignoux,Olivier Lada,Tarik Asselah,Céline Dorival,Christophe Hézode,Fabrice Carrat,Florence Nicot,Patrick Marcellin,F Mentré +18 more
TL;DR: It is shown how an on‐treatment model‐based approach could be used to individualize dose regimen and avoid the occurrence of RBV‐induced anemia and Peg‐IFN‐induced thrombocytopenia in the ANRS‐CO20‐CUPIC cohort of hepatitis C virus experienced patients.
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Molecular Crosstalk between the Hepatitis C Virus and the Extracellular Matrix in Liver Fibrogenesis and Early Carcinogenesis.
TL;DR: In this paper, the authors provide an update on mechanistic concepts of hepatitis C virus-related liver fibrosis/cirrhosis and early stages of carcinogenesis, with a dissection of the molecular details of the crosstalk during disease progression between hepatocytes, the extracellular matrix, and hepatic stellate cells.
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Correlation of serum hepatitis B core-related antigen with hepatitis B virus total intrahepatic DNA and covalently closed circular-DNA viral load in HIV-hepatitis B coinfection.
Lorenza N C Dezanet,Sarah Maylin,Audrey Gabassi,Hayette Rougier,Patrick Miailhes,Caroline Lascoux-Combe,Julie Chas,Pierre-Marie Girard,Constance Delaugerre,Fabien Zoulim,Karine Lacombe,Anders Boyd +11 more
TL;DR: qHBcrAg is a potential surrogate marker of cccDNA in HIV-HBV co-infected patients, yet might be less useful with undetectable serum HBV-DNA or HBeAg-negative status, yet whether qHBcr Ag provides further clinical utility compared to other serological markers remains debatable.
Journal ArticleDOI
Safety and efficacy of the combination simeprevir-sofosbuvir in HCV genotype 1- and 4-mono-infected patients from the French ANRS CO22 hepather cohort.
A Laurain,Sophie Metivier,Georges Haour,Dominique Larrey,Céline Dorival,Christophe Hézode,Fabien Zoulim,Patrick Marcellin,Marc Bourlière,Jean-Pierre Zarski,Dominique Thabut,Laurent Alric,Nathalie Ganne-Carrié,Paul Calès,Jean-Pierre Bronowicki,Ghassan Riachi,Claire Geist,Xavier Causse,Armand Abergel,Olivier Chazouillères,Philippe Mathurin,Dominique Guyader,Didier Samuel,Albert Tran,Véronique Loustaud-Ratti,Ventzislava Petrov-Sanchez,Alpha Diallo,Clovis Luzivika-Nzinga,Hélène Fontaine,Fabrice Carrat,Stanislas Pol +30 more
TL;DR: In this real life, observational, prospective cohort study, the 12-week sofosbuvir/simeprevir+/−ribavirin combination appears to be efficient and safe.