F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Epidermal Growth Factor Receptor-Dependent Mutual Amplification between Netrin-1 and the Hepatitis C Virus.
Marie-Laure Plissonnier,Thomas Lahlali,Maud Michelet,Fanny Lebossé,Jessica Cottarel,Melanie Beer,Gregory Neveu,David Durantel,Birke Bartosch,Rosita Accardi,Sophie Clément,Andrea Paradisi,Mojgan Devouassoux-Shisheboran,Shirit Einav,Patrick Mehlen,Fabien Zoulim,Romain Parent +16 more
TL;DR: Netrin-1 and HCV are reciprocal inducers in vitro and in patients, as seen from the increase in viral morphogenesis and viral entry, both phenomena converging toward an increase in the level of infectivity of HCV virions.
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Implementation of an in‐house quantitative real‐time polymerase chain reaction method for Hepatitis B virus quantification in West African countries
Saunab Ghosh,Amina Sow,C. Guillot,A. Jeng,Gibril Ndow,Ramou Njie,Souleymane Toure,Madoky Magatte Diop,Souleymane Mboup,Coumba Toure Kane,Maud Lemoine,Mark Thursz,Fabien Zoulim,Maimuna Mendy,Isabelle Chemin +14 more
TL;DR: This in‐house qRT‐PCR assay is recommended as a reliable alternative to commercial assays, for monitoring HBV viraemia in resource‐limited, highly endemic countries to reduce the cost and technical obstacles associated with commercial kits.
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Hepatitis B virus mutation pattern rtL180M+A181C+M204V may contribute to entecavir resistance in clinical practice
Yan Liu,Yi Zhou,Xiaodong Li,Ming Niu,Rongjuan Chen,Jinman Shao,Lanlan Si,Dan Luo,Yayun Lin,Le Li,Kai Zhang,Xiaohe Xiao,Zhihui Xu,Min Liu,Mengji Lu,Fabien Zoulim,Dongping Xu +16 more
TL;DR: Clinical and experimental data support rtL180M+A181C+M204V as a novel non-classical ETV-resistance mutation pattern and undetectable serum HBV DNA was achieved in two of five longitudinally followed patients who received switching-to TDF therapy, but not in the other three who received add-on adefovir therapy during observation.
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Emerging drugs for hepatitis B.
TL;DR: Discovery of new antiviral drugs and design of new treatment strategies are needed to manage chronic hepatitis B, which is still the main cause of cirrhosis and hepatocellular carcinoma worldwide.
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Hepatitis B virus infection enhances susceptibility toward adeno‐associated viral vector transduction in vitro and in vivo
Marianna Hösel,Julie Lucifora,Thomas Michler,Gisela Holz,M. Gruffaz,Stephanie Stahnke,Fabien Zoulim,Fabien Zoulim,David Durantel,Mathias Heikenwalder,Dirk Nierhoff,Rachel Millet,Anna Salvetti,Ulrike Protzer,Hildegard Büning +14 more
TL;DR: Investigation of the effect of HBV on adeno‐associated viral (AAV) vectors, the most frequently applied gene transfer vehicles for in vivo gene therapy, found that HBV greatly improved AAV transduction in cells replicating HBV and identified HBV protein x (HBx) as a key factor.