F
Fabien Zoulim
Researcher at French Institute of Health and Medical Research
Publications - 716
Citations - 40988
Fabien Zoulim is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 96, co-authored 641 publications receiving 35807 citations. Previous affiliations of Fabien Zoulim include Hotel Dieu Hospital & University of Orléans.
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Journal ArticleDOI
Preferential association of Hepatitis C virus with apolipoprotein B48-containing lipoproteins
Olivier Diaz,François Delers,Marianne Maynard,Sylvie Demignot,Fabien Zoulim,Jean Chambaz,Christian Trepo,Vincent Lotteau,Patrice Andre,Patrice Andre +9 more
TL;DR: LVPs were enriched dramatically and rapidly in triglycerides after a fat meal, raising the question of the contribution of the intestine to the viral load and suggest that the virus could take advantage of TRL assembly and secretion for its own production and ofTRL fate to be delivered to the liver.
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Antiviral effect of entecavir in chronic hepatitis B: influence of prior exposure to nucleos(t)ide analogues.
Jurriën G.P. Reijnders,Katja Deterding,Jörg Petersen,Fabien Zoulim,Teresa Santantonio,Maria Buti,Florian van Bömmel,Bettina E. Hansen,Heiner Wedemeyer,Harry L.A. Janssen +9 more
TL;DR: Entecavir proved to be efficacious in NA-naïve patients and should not be used in patients with previous lamivudine-resistance, yet it may still be an option in lamivudaine-experienced patients in case lamivUDine-Resistance never developed.
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Management of treatment failure in chronic hepatitis B
Fabien Zoulim,Stephen Locarnini +1 more
TL;DR: Management of treatment failure requires a precise clinical and accurate virologic monitoring as well as an early treatment intervention with appropriate complementary drugs with respect to their cross-resistance profile.
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Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B.
Fanny Lebossé,Fanny Lebossé,Barbara Testoni,Barbara Testoni,Judith Fresquet,Judith Fresquet,Floriana Facchetti,Enrico Galmozzi,Maëlenn Fournier,Maëlenn Fournier,Valérie Hervieu,Pascale Berthillon,Françoise Berby,Isabelle Bordes,David Durantel,David Durantel,Massimo Levrero,Massimo Levrero,Pietro Lampertico,Fabien Zoulim,Fabien Zoulim +20 more
TL;DR: The results indicate that chronic HBV infection has a suppressive effect on immune responses, which was more pronounced with high levels of hepatitis B virus surface antigen (HBsAg).
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Early inhibition of hepatocyte innate responses by hepatitis B virus
Souphalone Luangsay,M. Gruffaz,M. Gruffaz,Nathalie Isorce,Nathalie Isorce,Barbara Testoni,Barbara Testoni,Maud Michelet,Maud Michelet,Suzanne Faure-Dupuy,Suzanne Faure-Dupuy,Sarah Maadadi,Sarah Maadadi,Malika Ait-Goughoulte,Malika Ait-Goughoulte,Romain Parent,Romain Parent,Michel Rivoire,Hassan Javanbakht,Julie Lucifora,Julie Lucifora,David Durantel,David Durantel,Fabien Zoulim +23 more
TL;DR: The data provide strong evidence that HBV viral particles themselves can readily inhibit host innate immune responses upon virion/cell interactions, and may explain, at least partially, the "stealthy" character of HBV.