F
Fabrizio Tagliavini
Researcher at Carlo Besta Neurological Institute
Publications - 422
Citations - 21532
Fabrizio Tagliavini is an academic researcher from Carlo Besta Neurological Institute. The author has contributed to research in topics: Frontotemporal dementia & Amyloid. The author has an hindex of 73, co-authored 380 publications receiving 18785 citations. Previous affiliations of Fabrizio Tagliavini include University of Parma & Laval University.
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Journal ArticleDOI
Neurotoxicity of a prion protein fragment
Gianluigi Forloni,Nadia Angeretti,Roberto Chiesa,Enrico Monzani,Mario Salmona,Orso Bugiani,Fabrizio Tagliavini +6 more
TL;DR: It is reported here that neuronal death results from chronic exposure of primary rat hippocampal cultures to micromolar concentrations of a peptide corresponding to residues 106–126 of the amino-acid sequence deduced from human PrP complementary DNA.
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Identification of a second bovine amyloidotic spongiform encephalopathy: molecular similarities with sporadic Creutzfeldt-Jakob disease
Cristina Casalone,Gianluigi Zanusso,Pier Luigi Acutis,Sergio Ferrari,Lorenzo Capucci,Fabrizio Tagliavini,Salvatore Monaco,Maria Caramelli +7 more
TL;DR: Evidence of a second cattle TSE is provided, pathologically characterized by the presence of PrP-immunopositive amyloid plaques, as opposed to the lack of amyloids deposition in typical BSE cases, and by a different pattern of regional distribution and topology of brain PrP(Sc) accumulation.
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Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis
Jonathan D. Rohrer,Jennifer M. Nicholas,Jennifer M. Nicholas,David M. Cash,John C. van Swieten,Elise G.P. Dopper,Lize C. Jiskoot,Rick van Minkelen,Serge A.R.B. Rombouts,M. Jorge Cardoso,Shona Clegg,Miklos Espak,Simon Mead,David L. Thomas,Enrico De Vita,Mario Masellis,Sandra E. Black,Morris Freedman,Ron Keren,Bradley J. MacIntosh,Ekaterina Rogaeva,David F. Tang-Wai,Maria Carmela Tartaglia,Robert Laforce,Fabrizio Tagliavini,Pietro Tiraboschi,Veronica Redaelli,Sara Prioni,Marina Grisoli,Barbara Borroni,Alessandro Padovani,Daniela Galimberti,Elio Scarpini,Andrea Arighi,Giorgio G. Fumagalli,James B. Rowe,Ian Coyle-Gilchrist,Caroline Graff,Caroline Graff,Marie Fallström,Vesna Jelic,Vesna Jelic,Anne Kinhult Ståhlbom,Anne Kinhult Ståhlbom,Christin Andersson,Christin Andersson,Håkan Thonberg,Håkan Thonberg,Lena Lilius,Giovanni B. Frisoni,Giuliano Binetti,Michela Pievani,Martina Bocchetta,Luisa Benussi,Roberta Ghidoni,Elizabeth Finger,Sandro Sorbi,Benedetta Nacmias,Gemma Lombardi,Cristina Polito,Jason D. Warren,Sebastien Ourselin,Nick C. Fox,Martin N. Rossor +63 more
TL;DR: Structural imaging and cognitive changes can be identified 5-10 years before expected onset of symptoms in asymptomatic adults at risk of genetic frontotemporal dementia, which could help to define biomarkers that can stage presymPTomatic disease and track disease progression.
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Frontotemporal dementia and corticobasal degeneration in a family with a P301S mutation in tau.
Orso Bugiani,Jill R. Murrell,Giorgio Giaccone,Masato Hasegawa,Giuseppe Ghigo,Massimo Tabaton,Michela Morbin,Alberto Primavera,Francesco Carella,Claudio Solaro,Marina Grisoli,Mario Savoiardo,Maria Grazia Spillantini,Fabrizio Tagliavini,Michel Goedert,Bernardino Ghetti +15 more
TL;DR: One individual presented with frontotemporal dementia, whereas his son has corticobasal degeneration, demonstrating that the same primary gene defect in tau can lead to 2 distinct clinical phenotypes.
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A recessive mutation in the APP gene with dominant-negative effect on amyloidogenesis.
Giuseppe Di Fede,Marcella Catania,Michela Morbin,Giacomina Rossi,Silvia Suardi,Giulia Mazzoleni,Marco Merlin,Anna Rita Giovagnoli,Sara Prioni,Alessandra Erbetta,Chiara Falcone,Marco Gobbi,Laura Colombo,Antonio Bastone,Marten Beeg,Claudia Manzoni,Bruna Francescucci,Alberto Spagnoli,Laura Cantù,Elena Del Favero,Efrat Levy,Mario Salmona,Fabrizio Tagliavini +22 more
TL;DR: An APP mutation that causes disease only in the homozygous state, whereas heterozygous carriers were unaffected, consistent with a recessive Mendelian trait of inheritance is found, with implications for genetic screening and the potential treatment of Alzheimer's disease.