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Felix Chua
Researcher at National Institutes of Health
Publications - 91
Citations - 2123
Felix Chua is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Interstitial lung disease & Idiopathic pulmonary fibrosis. The author has an hindex of 19, co-authored 79 publications receiving 1508 citations. Previous affiliations of Felix Chua include Guy's and St Thomas' NHS Foundation Trust & University College London.
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Journal ArticleDOI
Pulmonary fibrosis: searching for model answers.
TL;DR: There are still good reasons to continue adapting and using one of its earliest examples, the bleomycin model, in post-genomic pulmonary fibrosis research, and a brief review of the exacting requirements will place the strengths of this particular model in perspective.
Journal ArticleDOI
Neutrophil elastase: mediator of extracellular matrix destruction and accumulation.
Felix Chua,Geoffrey J. Laurent +1 more
TL;DR: Emerging evidence suggests that the engagement of cellular pathways with more direct effects on fibrogenic mediator generation and collagen synthesis appears to underpin the actions of neutrophil elastase in promoting lung matrix accumulation.
Journal ArticleDOI
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study
Thomas M Drake,Annemarie B Docherty,Ewen M Harrison,Jennifer K Quint,Huzaifa Adamali,Huzaifa Adamali,Sarah Agnew,Suresh Babu,Chris Barber,Shaney L Barratt,Shaney L Barratt,Elisabeth Bendstrup,Stephen Bianchi,Diego Castillo Villegas,Nazia Chaudhuri,Felix Chua,R K Coker,William Chang,Anjali Crawshaw,Louise E. Crowley,Davinder Dosanjh,Christine A Fiddler,Ian Forrest,Peter M. George,Michael A Gibbons,Katherine Groom,Sarah Haney,Simon P. Hart,Emily Heiden,Michael Henry,Ling-Pei Ho,Rachel K. Hoyles,John M. Hutchinson,Killian Hurley,Killian Hurley,Mark Jones,S Jones,Maria Kokosi,Michael Kreuter,Laura Mackay,Siva Mahendran,George Margaritopoulos,Maria Molina-Molina,Philip L. Molyneaux,Aidan O'Brien,Katherine M.A. O'Reilly,Alice Packham,Helen Parfrey,Venerino Poletti,Joanna C. Porter,Elisabetta A. Renzoni,Pilar Rivera-Ortega,Anne-Marie Russell,Anne-Marie Russell,Gauri Saini,Lisa G. Spencer,Giulia M. Stella,Helen Stone,Sharon Sturney,David R Thickett,David R Thickett,Muhunthan Thillai,Tim Jm Wallis,Katie Ward,Athol U. Wells,Alex West,Melissa Wickremasinghe,Felix Woodhead,Glenn Hearson,Lucy Howard,J Kenneth Baillie,Peter J. M. Openshaw,Malcolm G Semple,Malcolm G Semple,Iain A. Stewart,R. Gisli Jenkins,R. Gisli Jenkins,Isaric C Investigators +77 more
TL;DR: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity, and Stringent precautions should be taken to avoid CO VID-19 in patients with I LD.
Journal ArticleDOI
Passive Stiffness of Myocardium From Congenital Heart Disease and Implications for Diastole
Rajiv Chaturvedi,Todd J. Herron,Robert M. Simmons,Darryl F. Shore,Pankaj Kumar,Babulal Sethia,Felix Chua,Efstathios Vassiliadis,Jonathan C. Kentish +8 more
TL;DR: The transition from normal to very-low stiffness myocytes may mark irreversible dilatation, and in vitro passive stiffness of volume- or pressure-overloaded myocardium mainly from congenital heart disease was related to increased myocardial stiffness.
Journal ArticleDOI
Mice lacking neutrophil elastase are resistant to bleomycin-induced pulmonary fibrosis.
Felix Chua,SE Dunsmore,SE Dunsmore,Peter H. Clingen,Steven E. Mutsaers,Steven D. Shapiro,Anthony W. Segal,Jürgen Roes,Geoffrey J. Laurent +8 more
TL;DR: Data point to novel and unexpected fibrogenic consequences of neutrophil elastase activity in the inflamed lung as evidenced by assessment of indices of DNA and cell damage.