S
Simon P. Hart
Researcher at Hull York Medical School
Publications - 176
Citations - 4771
Simon P. Hart is an academic researcher from Hull York Medical School. The author has contributed to research in topics: Idiopathic pulmonary fibrosis & Phagocytosis. The author has an hindex of 35, co-authored 165 publications receiving 3740 citations. Previous affiliations of Simon P. Hart include Borders General Hospital & Hull and East Yorkshire Hospitals NHS Trust.
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Journal ArticleDOI
How variation between individuals affects species coexistence
TL;DR: This work incorporates intraspecific variation into a common model of competition and identifies three pathways by which this variation affects coexistence: changes in competitive dynamics because of nonlinear averaging, changes in species' mean interaction strengths because of variation in underlying traits, and effects on stochastic demography.
Journal ArticleDOI
Genetic variants associated with susceptibility to idiopathic pulmonary fibrosis in people of European ancestry: a genome-wide association study
Richard J. Allen,Joanne Porte,Rebecca Braybrooke,Carlos Flores,Tasha E. Fingerlin,Justin M. Oldham,Beatriz Guillen-Guio,Shwu-Fan Ma,Tsukasa Okamoto,Alison E. John,Ma'en Obeidat,Ivana V. Yang,Amanda P. Henry,Richard Hubbard,Vidya Navaratnam,Gauri Saini,Norma Thompson,Helen Booth,Simon P. Hart,Michael Hill,Nik Hirani,Toby M. Maher,Robin J. McAnulty,Ann B. Millar,Philip L. Molyneaux,Helen Parfrey,Doris M Rassl,Moira K. B. Whyte,William A. Fahy,Richard P. Marshall,Eunice Oballa,Yohan Bossé,David C. Nickle,Don D. Sin,Wim Timens,Nick Shrine,Ian Sayers,Ian P. Hall,Imre Noth,David A. Schwartz,Martin D. Tobin,Louise V. Wain,Louise V. Wain,R. Gisli Jenkins +43 more
TL;DR: The identification of AKAP13 as a susceptibility gene for IPF increases the prospect of successfully targeting RhoA pathway inhibitors in patients with IPF.
Journal ArticleDOI
Genome-Wide Association Study of Susceptibility to Idiopathic Pulmonary Fibrosis.
Richard J. Allen,Beatriz Guillen-Guio,Justin M. Oldham,Shwu-Fan Ma,Amy Dressen,Megan L. Paynton,Luke M. Kraven,Ma'en Obeidat,Xuan Li,Michael Ng,Rebecca Braybrooke,Maria Molina-Molina,Maria Molina-Molina,Brian D. Hobbs,Rachel K. Putman,Phuwanat Sakornsakolpat,Helen Booth,William A. Fahy,Simon P. Hart,Michael Hill,Nik Hirani,Richard Hubbard,Robin J. McAnulty,Ann B. Millar,Vidyia Navaratnam,Eunice Oballa,Helen Parfrey,Gauri Saini,Moira K. B. Whyte,Yingze Zhang,Naftali Kaminski,Ayodeji Adegunsoye,Mary E. Strek,Margaret Neighbors,Xuting R. Sheng,Gunnar Gudmundsson,Vilmundur Gudnason,Hiroto Hatabu,David J. Lederer,Ani Manichaikul,John D. Newell,John D. Newell,George T. O'Connor,George T. O'Connor,Victor E. Ortega,Hanfei Xu,Tasha E. Fingerlin,Yohan Bossé,Ke Hao,Philippe Joubert,David C. Nickle,Don D. Sin,Wim Timens,Wim Timens,Dominic Furniss,Andrew P. Morris,Andrew P. Morris,Krina T. Zondervan,Ian P. Hall,Ian P. Hall,Ian Sayers,Ian Sayers,Martin D. Tobin,Martin D. Tobin,Toby M. Maher,Toby M. Maher,Michael H. Cho,Gary M. Hunninghake,David A. Schwartz,Brian L. Yaspan,Philip L. Molyneaux,Philip L. Molyneaux,Carlos Flores,Imre Noth,R. Gisli Jenkins,R. Gisli Jenkins,Louise V. Wain,Louise V. Wain +77 more
TL;DR: The observation that decreased DEPTOR expression associates with increased susceptibility to IPF supports recent studies demonstrating the importance of mTOR signaling in lung fibrosis, and new signals of association implicating KIF15 and MAD1L1 suggest a possible role of mitotic spindle-assembly genes in IPF susceptibility.
Journal ArticleDOI
Outcome of Hospitalization for COVID-19 in Patients with Interstitial Lung Disease: An International Multicenter Study
Thomas M Drake,Annemarie B Docherty,Ewen M Harrison,Jennifer K Quint,Huzaifa Adamali,Huzaifa Adamali,Sarah Agnew,Suresh Babu,Chris Barber,Shaney L Barratt,Shaney L Barratt,Elisabeth Bendstrup,Stephen Bianchi,Diego Castillo Villegas,Nazia Chaudhuri,Felix Chua,R K Coker,William Chang,Anjali Crawshaw,Louise E. Crowley,Davinder Dosanjh,Christine A Fiddler,Ian Forrest,Peter M. George,Michael A Gibbons,Katherine Groom,Sarah Haney,Simon P. Hart,Emily Heiden,Michael Henry,Ling-Pei Ho,Rachel K. Hoyles,John M. Hutchinson,Killian Hurley,Killian Hurley,Mark Jones,S Jones,Maria Kokosi,Michael Kreuter,Laura Mackay,Siva Mahendran,George Margaritopoulos,Maria Molina-Molina,Philip L. Molyneaux,Aidan O'Brien,Katherine M.A. O'Reilly,Alice Packham,Helen Parfrey,Venerino Poletti,Joanna C. Porter,Elisabetta A. Renzoni,Pilar Rivera-Ortega,Anne-Marie Russell,Anne-Marie Russell,Gauri Saini,Lisa G. Spencer,Giulia M. Stella,Helen Stone,Sharon Sturney,David R Thickett,David R Thickett,Muhunthan Thillai,Tim Jm Wallis,Katie Ward,Athol U. Wells,Alex West,Melissa Wickremasinghe,Felix Woodhead,Glenn Hearson,Lucy Howard,J Kenneth Baillie,Peter J. M. Openshaw,Malcolm G Semple,Malcolm G Semple,Iain A. Stewart,R. Gisli Jenkins,R. Gisli Jenkins,Isaric C Investigators +77 more
TL;DR: Patients with ILD are at increased risk of death from COVID-19, particularly those with poor lung function and obesity, and Stringent precautions should be taken to avoid CO VID-19 in patients with I LD.
Journal Article
CD44 regulates phagocytosis of apoptotic neutrophil granulocytes, but not apoptotic lymphocytes, by human macrophages.
TL;DR: It is demonstrated that phagocytosis of apoptotic neutrophils, but not apoptotic lymphocytes, by human monocyte-derived macrophages is augmented rapidly following ligation of CD44 by bivalent Abs in vitro, suggesting a novel role for CD44 in inflammation and tissue repair.