Journal ArticleDOI
Immortalization of murine microglial cells by a v-raf / v-myc carrying retrovirus
TLDR
Since BV-2 cells retain most of the morphological, phenotypical and functional properties described for freshly isolated microglial cells, it can be concluded that J2 virus infection has resulted in the immortalization of active microglia cells.About:
This article is published in Journal of Neuroimmunology.The article was published on 1990-05-01. It has received 952 citations till now. The article focuses on the topics: Cell culture & Microglia.read more
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The NALP3 inflammasome is involved in the innate immune response to amyloid-beta.
Annett Halle,Veit Hornung,Gabor C. Petzold,Cameron R. Stewart,Brian G. Monks,Thomas Reinheckel,Katherine A. Fitzgerald,Eicke Latz,Kathryn J. Moore,Douglas T. Golenbock +9 more
TL;DR: The NALP3 inflammasome is identified as a sensor of Aβ in a process involving the phagocytosis of A β and subsequent lysosomal damage and release of cathepsin B.
Journal ArticleDOI
CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer
Cameron R. Stewart,Lynda M. Stuart,Kim Wilkinson,Janine M. van Gils,Jiusheng Deng,Annett Halle,Annett Halle,Katey J. Rayner,Laurent Boyer,Ruiqin Zhong,William A. Frazier,Adam Lacy-Hulbert,Joseph El Khoury,Douglas T. Golenbock,Kathryn J. Moore,Kathryn J. Moore +15 more
TL;DR: It is shown that oxidized LDL and amyloid-β trigger inflammatory signaling through a heterodimer of Toll-like receptors 4 and 6 that is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands.
Journal ArticleDOI
Depletion of microglia and inhibition of exosome synthesis halt tau propagation
Hirohide Asai,Seiko Ikezu,Satoshi Tsunoda,Maria Medalla,Jennifer I. Luebke,Tarik F. Haydar,Benjamin Wolozin,Oleg Butovsky,Sebastian Kügler,Tsuneya Ikezu +9 more
TL;DR: It is found that depleting microglia dramatically suppressed the propagation of tau and reduced excitability in the dentate gyrus in this mouse model, and this data suggest that microglian involvement in tau propagation and the exosome secretion pathway may be a therapeutic target.
Journal ArticleDOI
Minocycline prevents nigrostriatal dopaminergic neurodegeneration in the MPTP model of Parkinson's disease.
Yansheng Du,Zhizhong Ma,Suizhen Lin,Richard Dodel,Feng Gao,Kelly R. Bales,Lazarose C. Triarhou,Eyassu Chernet,K.W. Perry,David L. Nelson,Susan H. Luecke,Lee A. Phebus,Frank P. Bymaster,Steven M. Paul,Steven M. Paul +14 more
TL;DR: The results suggest that minocycline blocks MPTP neurotoxicity in vivo by indirectly inhibiting MPTP/MPP+-induced glial iNOS expression and/or directly inhibiting NO-induced neurotoxicity, most likely by inhibiting the phosphorylation of p38 MAPK.
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Microglia: biology and pathology
TL;DR: A critical review of the literature shows that the concept of “(micro)glial inflammation” is still open to interpretation, despite a prevailing slant towards a negative meaning, and research on the role of microglia in synaptic plasticity is expected to yield an answer to the question whether microglias are the brain’s electricians.
References
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Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence
TL;DR: The glial fibrillary acidic (GFA) protein, a brain specific protein extracted from severely gliosed human tissue, is not species specific; cross-reaction occurs between anti-human GFA protein antibodies and brain extracts of rabbit, guinea pig, rat and dog.
Journal ArticleDOI
Characterization of ameboid microglia isolated from developing mammalian brain
D Giulian,TJ Baker +1 more
TL;DR: It is suggested that in vitro ameboid microglia differentiate into nonphagocytic cells similar to ramifiedmicroglia found in normal adult brain.
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The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex
Richard W. Price,Bruce J. Brew,John J. Sidtis,Marc K. Rosenblum,Adrienne C. Scheck,Paul D. Cleary +5 more
TL;DR: Within the context of the permissive effect of immunosuppression, genetic changes in HIV-1 may underlie the neuropathological heterogeneity of the AIDS dementia complex and its relatively independent course in relation to the systemic manifestations of AIDS noted in some patients.
Journal ArticleDOI
Serum and urinary lysozyme (muramidase) in monocytic and monomyelocytic leukemia
TL;DR: Present evidence indicates that ly sozyme is the principal, if not the sole, product of the proliferating monocytes in monocytic and monomyelocytic leukemia, and quantitation of serum and urine lysozyme should be a useful diagnostic procedure for these leukemias.