Showing papers in "Journal of Neuroimmunology in 1990"
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TL;DR: Since BV-2 cells retain most of the morphological, phenotypical and functional properties described for freshly isolated microglial cells, it can be concluded that J2 virus infection has resulted in the immortalization of active microglia cells.
952 citations
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TL;DR: Localization of beta-2 integrins in normal and Alzheimer disease temporal cortex was studied immunohistochemically and HLA-DR was detected on only a few microgla in control tissue, but was intensely expressed on large numbers of reactive microglia in Alzheimer tissue.
415 citations
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TL;DR: It is proposed that astrocyte-produced IL-6 may have a role in augmenting intracerebral immune responses in neurological diseases such as multiple sclerosis (MS), AIDS dementia complex (ADC), and viral infections.
318 citations
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TL;DR: While both serum TNF levels and nitrogen loss were increased after head injury, the elevation of TNF did not correlate strongly with nitrogen wasting.
234 citations
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TL;DR: Following lethal motor neuron injury microglia and perivascular cells, as well as brain macrophages derived from the latter two cell types, newly express antigens of the myelomonocytic lineage as recognized by the monoclonal antibodies ED1 and ED3.
232 citations
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TL;DR: Observations indicated that, in terms of regulation by cytokines, microglia are similar to mature cells in monocytic lineage.
211 citations
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TL;DR: Injection or rIML-1 into Lewis rats inhibited the induction of both clinical and histological signs of EAE, apparently by blocking sensitization of encephalitogenic BP-specific T cells and inducing BP-dependent suppressor cells.
202 citations
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TL;DR: Experimental allergic encephalomyelitis was induced in Biozzi AB/H (antibody high) mice by sensitization with spinal cord homogenate in adjuvant and these mice should prove valuable for the study of chronic relapsing EAE.
192 citations
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TL;DR: Significant paralytic-demyelinating disease was restored to infected, irradiated mice after the adoptive transfer of nylon wool nonadherent splenic cells and appeared to be restricted by the major histocompatibility complex (MHC), which indicates that the principal mechanisms of JHMV-induced demyelination are most likely immunopathological.
161 citations
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TL;DR: It is demonstrated that growth of adult human non-neoplastic astrocytes is stimulated by TNF alpha, an inflammatory cytokine produced primarily by macrophages but also by astroCytes.
139 citations
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TL;DR: It is demonstrated that physiologic concentrations ofmelatonin stimulate, in vitro, activated L3T4+ (CD4+) cells to release opioid agonist(s) that can reproduce in vivo the immunoenhancing and anti-stress effects on thymus cellularity and antibody production of melatonin and compete with specific binding of [3H]naloxone to mouse brain membranes.
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TL;DR: It is demonstrated that TMEV-induced demyelinating disease can occur in the apparent absence of neuroantigen-specific autoimmune responses, and the relationship of the present results to the immunopathology of multiple sclerosis is discussed.
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TL;DR: It is suggested that the induction of ICAM-1 on CNS endothelia may be important in antigen presentation or in promoting lymphocyte extravasation across the blood-brain barrier in inflammatory disorders of the CNS.
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TL;DR: It is demonstrated that T cells with novel epitope specificities and class II restriction requirements can be generated during the course of CREAE and the possibility that such cells may be involved in the pathogenesis of this chronic autoimmune illness is suggested.
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TL;DR: In this article, a histological and immunocytochemically examined multiple sclerosis (MS) and control brains for the presence of mast cells and IgE-positive cells, but not in controls.
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TL;DR: TGF-β might be a potential regulator of CNS inflammation and antagonized hyperinduction of astrocyte major histocompatibility complex (MHC) class II antigen expression by interferon-γ and tumor necrosis factor-α.
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TL;DR: The self-limiting character of GBS and the therapeutic effect of IVIg in CIDP are dependent on suppression of auto-antibodies, and this suppression may be mediated by anti-idiotypes present in recovered GBS patients and in the normal donor population contributing to IVIG.
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TL;DR: Intense immunofluorescence was observed in cells resembling oligodendrocytes when sections of adult rat spinal cords were immunostained with antibodies against sheep glutamine synthetase, and colocalization with 2',3'-cyclic nucleotide-3'-phosphohydrolase in spinal cord supported the designation of the GS-positive cells as oligod endocrine cells.
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TL;DR: The results indicate that astrocyte class II mRNA expression is mediated by newly synthesized proteins induced by IFN-γ and/or IF-γ/TNF-α, which may be important in the initiation and perpetuation of intracerebral immune responses.
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TL;DR: Thyroid-stimulating hormone (TSH) and thyrotropin-releasing hormone (TRH) antagonize the involution of the thymus produced by prednisolone, and pineal melatonin exerts its varied regulatory functions via hypothalamic TRH.
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TL;DR: It is demonstrated that the synthetic peptide SP-26 can induce severe EAN in Lewis rats in a dose-dependent manner and specific T cell lines reactive to SP-25 can be generated from the lymph nodes of SP- 26-immunized rats.
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TL;DR: The data suggest that the increase in norepinephrine and serotonin release in mouse hypothalamus during the acute-phase response to infection is partially mediated by the actions of arachidonic acid metabolites.
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TL;DR: It is suggested that T lymphocytes are frequently present in nerves obtained from patients with various types of neuropathies and raise questions about factors that attract T lymphocyte into nerve that may be important in pathogenesis.
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TL;DR: Results suggest hypothalamic-releasing hormones such as CRH may have a biologically relevant role in the modulation of immune cells either directly or indirectly through the induction of neuropeptide hormones known to have immunomodulatory capabilities.
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TL;DR: It is inferred that humans are able to develop anti-MenB humoral responses, that such responses could initiate autoimmune disorders or be potentially detrimental by interfering with processes mediated by N-CAM interactions, and that the development of a vaccine against group B meningitidis should be considered with caution.
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TL;DR: Guinea pigs immunized with bovine spinal cord ventral horn homogenate develop muscle weakness with electromyographic and morphologic evidence of denervation, which suggests that a number of cytoplasmic and membrane antigens may give rise to an immunologically based attack on the motor system.
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TL;DR: In blood from MS and OIND patients, anti-MBP IgG antibody secreting cells were detected infrequently and at low numbers, and the anti- MBP antibody response is strongly restricted to the IgG isotype.
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TL;DR: It is concluded that lymphocytes produce an irGHRH that is similar to hypothalamic GHRH in terms of bioactivity, antigenicity, and molecular weight and demonstrates a potential regulatory loop between the immune and neuroendocrine tissues.
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TL;DR: Results indicate that restraint stress-induced activation of the HPA axis occurs without accompanying alterations in immune function.
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TL;DR: Observations indicate that TNF-alpha could act in an autocrine fashion to induce the proliferation of this malignant glioma cell line and that TNP-alpha exerts its effect by binding to specific T NF-alpha receptors whose expression was enhanced by IFN-gamma.